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wound healing activity of Ullucus tuberosus,an Andean tuber crop

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Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 538-543页

作者： Nathalie Heil Karent Bravo Andrés Montoya Sara Robledo Edison Osorio Grupo de Investigación en Sustancias Bioactivas Facultad de Ciencias Farmacéuticas y AlimentariasUniversidad de Antioquia PECET–Medical Research Institute School of MedicineUniversity of Antioquia

Objective:This study was designed to investigate the wound healing activity of aqueous extracts of Ullucus tuberosus(***) using in vitro ***:Lyophilized pulp and acetone extracts of *** were produced using ultrasound *** capacity for collagenase activation was evaluated using fluorescence detection of the enzymatic ***,the influence of *** extracts on cell proliferation,cell migration and synthesis of the extracellular matrix(ECM)proteins,metalloproteinase(MMP-1) and pro-collagen was analyzed using human dermal fibroblasts in ***:An increase in collagenase activity of 12% supports the utility of *** as an agent for scar *** addition,the extracts showed an increase in the proliferation and migration of human dermal fibroblasts and the production of pro-collagen and MMP-1 after treatment with *** *** increase in proliferation,migration and pro-collagen levels positively influenced the regeneration of scarless tissue during the proliferation phase,whereas the increase in MMP-1 may have favored the wound healing process during the remodeling and cellular differentiation ***:The results of this study show for first time that *** is a promising candidate to support scarless tissue regeneration.

关键词： wound healing Collagenase Pro-collagen MMP-1 Ullucus tuberosus

wound healing effect of methanolic leaf extract of Napoleona vogelii(Family:Lecythidaceae) in rats

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Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 620-624页

作者： Adiele LC Adiele RC Enye JC Department of Pharmacology and Toxicology Faculty of PharmacyMadonna UniversityEleleRiver StateNigeria Department of Pharmacy Federal Medical CenterOwerriImo StateNigeria Department of Anatomy and Cell Biology Division of Biomedical SciencesCollege of MedicineUniversity of SaskatchewanSaskatoonSKS7N 5E5Canada Cameco MS Neuroscience Research Center Saskatoon City HospitalSaskatoonSKS7K 0M7Canada

Objective:To investigate the wound healing properly of Napoleona vogelii leaf extract in folkloric ***:Roth sexes of adult albino rats(n=25) were used in this study and another group(n=30) were subjected to acute toxicity test(LD_(50)) of the plant *** the LD_(50),three randomized groups of 5 rats were first treated with 10,100,1 000 mg/kg body weight(bw),*** w as followed by a second treatment of 1500,3000,and 5 000 mg/kg bw of the leaf extract with continual monitoring of the animals for mortality or *** wounds(1.3cm) were created on the skin of five groups of 5 rals using surgical blade under *** first group was topically treated with petroleum jelly alone,group 2 was topically applied 400 mg/mL w/v of the reference drug,Neobaein,while group 3-5 were topically treated with 5-50 mg/mL w/v of the plant extract,***:The percentage yield of the extract was 49.80%w/w dry *** phytochemical analysis revealed several bioactive constituents including glycosides,tannins,alkaloids,***,steroids,proteins,and *** LD_(50) was beyond our experimental limit and was not *** concentrations(5,20,and 50mg/mL w/v) of the extract had significant(ANOVA,Phealing effect on the incision wounds giving rise to 125%-140% while treatmentawith Neobacin resulted in 150% healing effect on the third treatment regimen compared to the control(100%).Conclusions:These data indicate that Napoleona vogelii leaf extract contains potent bioactive compounds containing wound healing activity,substantiating its use as a wound healer in folkloric medicine.

关键词： wound healing Napoleona vogelii Petroleum jelly Neobacin Folkloric medicine

wound healing center establishment and new technology application in improving the wound healing quality in China

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Burns & Trauma 2020年第1期8卷 67-70页

作者： Xiaobing Fu wound healing Unit Medical Innovation Department and the Fourth Medical CenterPLA General Hospital and PLA Medical College28 Fu Xian RoadHaidian DistrictBeijing 100853China

wound healing,tissue repair and regenerative medicine are in great demand,and great achievements in these fields have been *** recent years,many of these successes have benefitted patients,especially in the field of chronic skin ***,perfect tissue repair and regeneration of damaged tissues and organs are still great challenges in the management of trauma and *** this paper,the main achievements in wound healing,tissue repair and regeneration in China are reviewed and the establishment of wound healing centers and new technology application in improving wound healing quality in patients in China is highlighted.

关键词： Trauma wound healing Tissue repair wound healing center

Prussian blue and collagen loaded chitosan nanofibers with NIR-controlled NO release and photothermal activities for wound healing

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Journal of Materials Science & Technology 2021年第34期93卷 17-27页

作者： Wenyu Wang Dejun Ding Kunpeng Zhou Man Zhang Weifen Zhang Fang Yan Ni Cheng College of Pharmacy Weifang Medical UniversityWeifang261053China

Nitric oxide(NO)has emerged as a potential wound therapeutic agent due to its pivotal role in the wound healing ***,NO-based therapy for clinical applications is still restricted due to its gaseous state and short *** we exploited a wound dressing by incorporating sodium nitroprusside doped prussian blue nanoparticals and Type I collagen into the chitosan/poly(vinyl alcohol)nanofibers through the electrospinning *** hybrid nanofibrous scaffold possess the excellent abilities of NIR controlled NO release,photothermal therapy,and imitation of extra-cellular matrix-like *** synergistic effects could enhance their anti-bactericidal effects in vitro and furthermore accelerate wound healing in vivo when compared to control *** analysis demonstrated the scaffold could promote fibroblast growth and accelerate ***,no apparent histological toxicology and negligible damage to major organs were observed,which provided sufficient biosafety for in vivo *** data indicate the fabricated hybrid nanofibrous scaffold could be used as an ideal candidate for accelerating wound healing and treating chronic wounds.

关键词： wound healing Nitric oxide NIR controlled Prussian blue nanoparticals Photothermal therapy Nanofibrous scaffold

Sprayed PAA-CaO_(2)nanoparticles combined with calcium ions and reactive oxygen species for antibacterial and wound healing

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Regenerative Biomaterials 2023年第1期10卷 1356-1371页

作者： Hong Yu Jiale Sun Kepeng She Mingqi Lv Yiqiao Zhang Yawen Xiao Yangkun Liu Changhao Han Xinyue Xu Shuqing Yang Guixue Wang Guangchao Zang Tissue and Cell Biology Lab Teaching&Management CenterChongqing Medical UniversityChongqing 400016China Chongqing University Central Hospital Chongqing Emergency Medical CenterChongqing 400030China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China Jinfeng Laboratory Chongqing 401329China

The most common socioeconomic healthcare issues in clinical are burns,surgical incisions and other skin *** lesion healing can be achieved with nanomedicines and other drug application *** study developed a nano-spray based on cross-linked amorphous calcium peroxide(CaO_(2))nanoparticles of polyacrylic acid(PAA)for treating skin wounds(PAA-CaO_(2)nanoparticles).CaO_(2)serves as a‘drug’precursor,steadily and continuously releasing calcium ions(Ca^(2+))and hydrogen peroxide(H_(2)O_(2))under mildly acidic conditions,while PAA-CaO_(2)nanoparticles exhibited good spray behavior in aqueous *** demonstrated that PAA-CaO_(2)nanoparticles exhibited low cytotoxicity and allowed L929 cells proliferation and migration in *** effectiveness of PAA-CaO_(2)nanoparticles in promoting wound healing and inhibiting bacterial growth in vivo was assessed in SD rats using full-thickness skin defect and Staphylococcus aureus(***)-infected wound models based *** results revealed that PAA-CaO_(2)nanoparticles demonstrated significant advantages in both ***,the infected rats’skin defects healed in 12 *** benefits are linked to the functional role of Ca^(2+)coalesces with H_(2)O_(2)as known antibacterial and healing-promoted ***,we developed nanoscale PAA-CaO_(2)sprays to prevent bacterial development and heal skin lesions.

关键词： polyacrylic acid calcium peroxide nanomedicines antibacterial wound healing

Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing

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Bio-Design and Manufacturing 2023年第3期6卷 268-283页

作者： Lixing Zhang Xin Miao Meijia Wang Aihua Shi Jingwen Wang Zhonglin Ma Yunhai Zhang Jingzhong Zhang Shuang Yu Suzhou Institute of Biomedical Engineering and Technology(SIBET) Chinese Academy of SciencesSuzhou 215163China Department of Biomedical Engineering School of Medical ImagingXuzhou Medical UniversityXuzhou 221004China Zhengzhou Zhongke Institute of Biomedical Engineering and Technology Affiliated with SIBET Zhengzhou 450001China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China School of Radiation Medicine and Protection Soochow UniversitySuzhou 215123China

The process of wound healing is routinely evaluated by histological evaluation in the clinic,which may cause scarring and secondary *** confocal microscopy(RCM)represents a noninvasive,real-time imaging technique that allows in vivo evaluation of the *** RCM was wide-probe-based,which limited its application on uneven and covered *** this study,we report the development of a portable reflectance confocal microscope(PRCM)in which all components were assembled in a handheld *** the size and weight of the PRCM were reduced based on the use of a microelectromechanical system,the resolution was kept at 0.91μm,and the field of view of the system was 343μm×532μ*** used in vivo,the PRCM was able to visualize cellular and nuclear morphology for both mouse and human *** evaluations were then performed on wounds after topically applied mesenchymal stem cells(MSCs)or saline *** PRCM allowed visualization of the formation of collagen bundles,re-epithelization from the wound edge to the wound bed,and hair follicle regeneration,which were consistent with histological ***,we offer new insights into monitoring the effects of topically applied MSCs on the process of wound healing by using *** study illustrates that the newly developed PRCM represents a promising device for real-time,noninvasive monitoring of the dynamic process of wound healing,which demonstrates its potential to diagnose,monitor,or predict disease in clinical wound therapy.

关键词： Portable reflectance confocal microscope wound healing Noninvasive optical imaging Real-time in vivo visualization

3D Bioprinted Skin Substitutes for Accelerated wound healing and Reduced Scar

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Journal of Bionic Engineering 2021年第4期18卷 900-914页

作者： Qin Lian Tian Jiao Tingze Zhao Huichao Wang Siming Yang Dichen Li State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an710049China Chinese PLA General Hospital Beijing100853China

The shortage of skin for grafting continues to be a major problem in the treatment of serious skin injuries.3D bioprinting provides a new way to solve this ***,current 3D printed skin is less effective in treatment of large wounds because of severe shrinkage and *** this study,bionically designed bilayer skin was fabricated using an extrusion-based bioprinter and a gelatin/sodium alginate/gelatin methacrylate hydrogel with excellent physical and biological ***-thickness skin wounds were created in the back of nude mice and treated with bioprinted skin or *** skin accelerated wound healing,reduced wound contraction and scarring,and facilitated wound skin epithelialization compared with the bioprinted hydrogel or untreated *** skin from the wound was collected 28 days after grafting for histology and immunofluorescence *** thickness of the dermis and epidermis of the bioprinted skin was similar to that of nude *** formation in the dermis and dense keratinocytes in the epidermis of the bioprinted skin were *** study provides a potential treatment strategy for reducing skin contraction and scar in large skin wounds.

关键词： 3D bioprinting bionic design skin substitutes wound healing reducing scar

FeS@LAB-35@Ti_(3)C_(2)as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing

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Nano Research 2023年第2期16卷 2840-2850页

作者： Gaoqi Sun Xuefeng Jiang Cheng Liu Saijie Song Jun Zhang Jian Shen National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Medical School Nanjing UniversityNanjing 210093China Jiangsu Engineering Research Center of Interfacial Chemistry Nanjing UniversityNanjing 210023China

The abuse of antibiotics leads to a significant increase in bacterial resistance,which makes it difficult to treat bacterial ***,it is urgent to develop new strategies for efficient antibacterial and wound ***,nanozymes based antibacterial agents have attracted increasing attention for their multifunction and high *** this study,we report a FeS@lauramidopropyl betaine(LAB-35)@Ti_(3)C_(2)nanozyme as a high-efficiency antibacterial agent for near infrared(NIR)light induced photothermal enhanced chemodynamic antibacteria and wound *** FeS@LAB-35@Ti_(3)C_(2)nanozyme possesses peroxidase-like catalysis activity,which can promote the generation of hydroxyl radicals(·OH)through catalyzing the decomposition of H_(2)O_(2).FeS@LAB-35@Ti_(3)C_(2)has photothermal conversion efficiency(η=65.1%),and it exhibits enhanced catalytic activity under NIR light *** in vitro antibacterial experiments demonstrate the excellent antibacterial activity of FeS@LAB-35@Ti_(3)C_(2)against representative Gram-negative Escherichia coli and Gram-positive Staphylococcus *** animal experiments indicate that FeS@LAB-35@Ti_(3)C_(2)nanozyme can effectively inhibit wound ulceration and promote wound ***,this study proposes FeS@LAB-35@Ti_(3)C_(2)nanozyme that integrates chemodynamic and photothermal therapy,which provides an efficient strategy for bacterial inhibition and wound healing.

关键词： MXene FeS nanozyme photothermal enhanced chemodynamic antibacterial activity wound healing

Enhanced burn wound healing by controlled-release 3D ADMSC-derived exosome-loaded hyaluronan hydrogel

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Regenerative Biomaterials 2024年第5期3卷 106-120页

作者： Delong Zhu Ying Hu Xiangkai Kong Yuansen Luo Yi Zhang Yu Wu Jiameng Tan Jianwei Chen Tao Xu Lei Zhu Department of Dermatology&Plastic Surgery The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630China Department of the Second Plastic Surgery The First People’s Hospital of FoshanFoshan 528000China Department of Research and Development Huaqing Zhimei(Shenzhen)Biotechnology Co.LtdShenzhen 518107People’s Republic of China Center for Bio-Intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in ShenzhenTsinghua UniversityShenzhen 518057People’s Republic of China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055People’s Republic of China

Adipose mesenchymal stem cell(ADMSC)-derived exosomes(ADMSC-Exos)have shown great potential in regenerative medicine and been evidenced benefiting wound repair such as ***,the low yield,easy loss after direct coating,and no suitable loading system to improve their availability and efficacy hinder their clinical application for wound *** few studies focused on the comparison of biological functions between exosomes derived from different culture techniques,especially in exosome-releasing hydrogel ***,we designed a high-performance exosome controllable releasing hydrogel system for burn wound healing,namely loading 3D-printed microfiber culture-derived exosomes in a highly biocompatible hyaluronic acid(HA).In this project,we compared the biological functions in vitro and in a burn model among exosomes derived from the conventional two-dimensional(2D)plate culture(2D-Exos),microcarrier culture(2.5D-Exos),and 3D-printed microfiber culture(3D-Exos).Results showed that compared with 2D-Exos and 2.5D-Exos,3D-Exos promoted HACATs and HUVECs cell proliferation and migration more ***,3D-Exos had stronger angiogenesis-promoting effects in tube formation of(HUVECs)***,we found HA-loaded 3D-Exos showed better burn wound healing promotion compared to 2D-Exos and 2.5D-Exos,including accelerated burn wound healing rate and better collagen *** study findings reveal that the HA-loaded,controllable-release 3D-Exos repair system distinctly augments therapeutic efficacy in terms of wound healing,while concurrently introducing a facile application *** system markedly bolsters the exosomal loading efficiency,provides a robust protective milieu,and potentiates the inherent biological functionalities of the *** findings provide a rationale for more efficient utilization of high-quality and high-yield 3D exosomes in the future,and a novel strategy for healing severe burns.

关键词： adipose-derived mesenchymal stem cells exosomes 3D microfiber culture hyaluronic acid hydrogel burn wound healing