3D Bioprinted Skin Substitutes for Accelerated Wound Healing and Reduced Scar
作者机构：State Key Laboratory for Manufacturing System EngineeringXi’an Jiaotong UniversityXi’an710049China Chinese PLA General HospitalBeijing100853China
出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)
年 卷 期：2021年第18卷第4期
页 面：900-914页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0802[工学-机械工程] 0836[工学-生物工程] 0702[理学-物理学] 080201[工学-机械制造及其自动化]
基 金：This work was supported by the National Key R&D Program of China(No.2018YFE0207900) the Development projects of Key research of People’s Liberation Army(No.BWS17J036,18-163-13-ZT-003-011-01) the National Natural Science Foundation of China(51835010 and 51375371)
主 题：3D bioprinting bionic design skin substitutes wound healing reducing scar
摘 要：The shortage of skin for grafting continues to be a major problem in the treatment of serious skin injuries.3D bioprinting provides a new way to solve this ***,current 3D printed skin is less effective in treatment of large wounds because of severe shrinkage and *** this study,bionically designed bilayer skin was fabricated using an extrusion-based bioprinter and a gelatin/sodium alginate/gelatin methacrylate hydrogel with excellent physical and biological ***-thickness skin wounds were created in the back of nude mice and treated with bioprinted skin or *** skin accelerated wound healing,reduced wound contraction and scarring,and facilitated wound skin epithelialization compared with the bioprinted hydrogel or untreated *** skin from the wound was collected 28 days after grafting for histology and immunofluorescence *** thickness of the dermis and epidermis of the bioprinted skin was similar to that of nude *** formation in the dermis and dense keratinocytes in the epidermis of the bioprinted skin were *** study provides a potential treatment strategy for reducing skin contraction and scar in large skin wounds.
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