Sprayed PAA-CaO_(2)nanoparticles combined with calcium ions and reactive oxygen species for antibacterial and wound healing

作     者：Hong Yu Jiale Sun Kepeng She Mingqi Lv Yiqiao Zhang Yawen Xiao Yangkun Liu Changhao Han Xinyue Xu Shuqing Yang Guixue Wang Guangchao Zang 

作者机构：Tissue and Cell BiologyLab Teaching&Management CenterChongqing Medical UniversityChongqing 400016China Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400030China Key Laboratory for Biorheological Science and Technology of Ministry of EducationState and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China Jinfeng LaboratoryChongqing 401329China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2023年第10卷第1期

页      面：1356-1371页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：supported by grants from the Natural Science Foundation of Chongqing(cstc2020jcyj-msxmX0330,cstc2021jsyjyzysbA0057) the National Natural Science Foundation of China(31971242,12032007) the Science and Technology Innovation Project of Jinfeng Laboratory,Chongqing,China(jfkyjf202203001) the Project of Tutorial System of Medical Undergraduate in Lab Teaching&Management Center in Chongqing Medical University(LTMCMTS202107) 

主　　题：polyacrylic acid calcium peroxide nanomedicines antibacterial wound healing 

摘      要：The most common socioeconomic healthcare issues in clinical are burns,surgical incisions and other skin *** lesion healing can be achieved with nanomedicines and other drug application *** study developed a nano-spray based on cross-linked amorphous calcium peroxide(CaO_(2))nanoparticles of polyacrylic acid(PAA)for treating skin wounds(PAA-CaO_(2)nanoparticles).CaO_(2)serves as a‘drug’precursor,steadily and continuously releasing calcium ions(Ca^(2+))and hydrogen peroxide(H_(2)O_(2))under mildly acidic conditions,while PAA-CaO_(2)nanoparticles exhibited good spray behavior in aqueous *** demonstrated that PAA-CaO_(2)nanoparticles exhibited low cytotoxicity and allowed L929 cells proliferation and migration in *** effectiveness of PAA-CaO_(2)nanoparticles in promoting wound healing and inhibiting bacterial growth in vivo was assessed in SD rats using full-thickness skin defect and Staphylococcus aureus(***)-infected wound models based *** results revealed that PAA-CaO_(2)nanoparticles demonstrated significant advantages in both ***,the infected rats’skin defects healed in 12 *** benefits are linked to the functional role of Ca^(2+)coalesces with H_(2)O_(2)as known antibacterial and healing-promoted ***,we developed nanoscale PAA-CaO_(2)sprays to prevent bacterial development and heal skin lesions.