Prussian blue and collagen loaded chitosan nanofibers with NIR-controlled NO release and photothermal activities for wound healing

作     者：Wenyu Wang Dejun Ding Kunpeng Zhou Man Zhang Weifen Zhang Fang Yan Ni Cheng Wenyu Wang;Dejun Ding;Kunpeng Zhoou;Man Zhang;Weifen Zhang;Fang Yan;Ni Cheng

作者机构：College of PharmacyWeifang Medical UniversityWeifang261053China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2021年第93卷第34期

页      面：17-27页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：NNSFC(21901186,82004163) NSF of Shandong Province(ZR2019BB032,ZR2020MH400,ZR2020QH324)for financial support 

主　　题：Wound healing Nitric oxide NIR controlled Prussian blue nanoparticals Photothermal therapy Nanofibrous scaffold 

摘      要：Nitric oxide(NO)has emerged as a potential wound therapeutic agent due to its pivotal role in the wound healing ***,NO-based therapy for clinical applications is still restricted due to its gaseous state and short *** we exploited a wound dressing by incorporating sodium nitroprusside doped prussian blue nanoparticals and Type I collagen into the chitosan/poly(vinyl alcohol)nanofibers through the electrospinning *** hybrid nanofibrous scaffold possess the excellent abilities of NIR controlled NO release,photothermal therapy,and imitation of extra-cellular matrix-like *** synergistic effects could enhance their anti-bactericidal effects in vitro and furthermore accelerate wound healing in vivo when compared to control *** analysis demonstrated the scaffold could promote fibroblast growth and accelerate ***,no apparent histological toxicology and negligible damage to major organs were observed,which provided sufficient biosafety for in vivo *** data indicate the fabricated hybrid nanofibrous scaffold could be used as an ideal candidate for accelerating wound healing and treating chronic wounds.