Wound healing activity of Ullucus tuberosus,an Andean tuber crop
Wound healing activity of Ullucus tuberosus,an Andean tuber crop作者机构：Grupo de Investigación en Sustancias BioactivasFacultad de Ciencias Farmacéuticas y AlimentariasUniversidad de Antioquia PECET–Medical Research InstituteSchool of MedicineUniversity of Antioquia
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2017年第7卷第6期
页 面：538-543页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the Universidad de Antioquia CODI-Estrategia de Sostenibilidad 2016-2017 GISB
主 题：Wound healing Collagenase Pro-collagen MMP-1 Ullucus tuberosus
摘 要：Objective:This study was designed to investigate the wound healing activity of aqueous extracts of Ullucus tuberosus(***) using in vitro ***:Lyophilized pulp and acetone extracts of *** were produced using ultrasound *** capacity for collagenase activation was evaluated using fluorescence detection of the enzymatic ***,the influence of *** extracts on cell proliferation,cell migration and synthesis of the extracellular matrix(ECM)proteins,metalloproteinase(MMP-1) and pro-collagen was analyzed using human dermal fibroblasts in ***:An increase in collagenase activity of 12% supports the utility of *** as an agent for scar *** addition,the extracts showed an increase in the proliferation and migration of human dermal fibroblasts and the production of pro-collagen and MMP-1 after treatment with *** *** increase in proliferation,migration and pro-collagen levels positively influenced the regeneration of scarless tissue during the proliferation phase,whereas the increase in MMP-1 may have favored the wound healing process during the remodeling and cellular differentiation ***:The results of this study show for first time that *** is a promising candidate to support scarless tissue regeneration.
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