Wound healing effect of methanolic leaf extract of Napoleona vogelii(Family:Lecythidaceae) in rats

作     者：Adiele LC Adiele RC Enye JC 

作者机构：Department of Pharmacology and ToxicologyFaculty of PharmacyMadonna UniversityEleleRiver StateNigeria Department of PharmacyFederal Medical CenterOwerriImo StateNigeria Department of Anatomy and Cell BiologyDivision of Biomedical SciencesCollege of MedicineUniversity of SaskatchewanSaskatoonSKS7N 5E5Canada Cameco MS Neuroscience Research CenterSaskatoon City HospitalSaskatoonSKS7K 0M7Canada 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第8期

页      面：620-624页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Wound healing Napoleona vogelii Petroleum jelly Neobacin Folkloric medicine 

摘      要：Objective:To investigate the wound healing properly of Napoleona vogelii leaf extract in folkloric ***:Roth sexes of adult albino rats(n=25) were used in this study and another group(n=30) were subjected to acute toxicity test(LD_(50)) of the plant *** the LD_(50),three randomized groups of 5 rats were first treated with 10,100,1 000 mg/kg body weight(bw),*** w as followed by a second treatment of 1500,3000,and 5 000 mg/kg bw of the leaf extract with continual monitoring of the animals for mortality or *** wounds(1.3cm) were created on the skin of five groups of 5 rals using surgical blade under *** first group was topically treated with petroleum jelly alone,group 2 was topically applied 400 mg/mL w/v of the reference drug,Neobaein,while group 3-5 were topically treated with 5-50 mg/mL w/v of the plant extract,***:The percentage yield of the extract was 49.80%w/w dry *** phytochemical analysis revealed several bioactive constituents including glycosides,tannins,alkaloids,***,steroids,proteins,and *** LD_(50) was beyond our experimental limit and was not *** concentrations(5,20,and 50mg/mL w/v) of the extract had significant(ANOVA,P0.05) healing effect on the incision wounds giving rise to 125%-140% while treatmentawith Neobacin resulted in 150% healing effect on the third treatment regimen compared to the control(100%).Conclusions:These data indicate that Napoleona vogelii leaf extract contains potent bioactive compounds containing wound healing activity,substantiating its use as a wound healer in folkloric medicine.