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Wound healing effect of methanolic leaf extract of Napoleona vogelii(Family:Lecythidaceae) in rats

Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 620-624页

作者： Adiele LC Adiele RC Enye JC Department of Pharmacology and Toxicology Faculty of PharmacyMadonna UniversityEleleRiver StateNigeria Department of Pharmacy Federal Medical CenterOwerriImo StateNigeria Department of Anatomy and Cell Biology Division of Biomedical SciencesCollege of MedicineUniversity of SaskatchewanSaskatoonSKS7N 5E5Canada Cameco MS Neuroscience Research Center Saskatoon City HospitalSaskatoonSKS7K 0M7Canada

Objective:To investigate the wound healing properly of Napoleona vogelii leaf extract in folkloric ***:Roth sexes of adult albino rats(n=25) were used in this study and another group(n=30) were subjected to acute toxicity test(LD_(50)) of the plant *** the LD_(50),three randomized groups of 5 rats were first treated with 10,100,1 000 mg/kg body weight(bw),*** w as followed by a second treatment of 1500,3000,and 5 000 mg/kg bw of the leaf extract with continual monitoring of the animals for mortality or *** wounds(1.3cm) were created on the skin of five groups of 5 rals using surgical blade under *** first group was topically treated with petroleum jelly alone,group 2 was topically applied 400 mg/mL w/v of the reference drug,Neobaein,while group 3-5 were topically treated with 5-50 mg/mL w/v of the plant extract,***:The percentage yield of the extract was 49.80%w/w dry *** phytochemical analysis revealed several bioactive constituents including glycosides,tannins,alkaloids,***,steroids,proteins,and *** LD_(50) was beyond our experimental limit and was not *** concentrations(5,20,and 50mg/mL w/v) of the extract had significant(ANOVA,Pneobacin resulted in 150% healing effect on the third treatment regimen compared to the control(100%).Conclusions:These data indicate that Napoleona vogelii leaf extract contains potent bioactive compounds containing wound healing activity,substantiating its use as a wound healer in folkloric medicine.

关键词： Wound healing Napoleona vogelii Petroleum jelly neobacin Folkloric medicine

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