Hydrocortisone, ascorbic acid and thiamine for sepsis: Is the jury out?

作     者：Paul Ellis Marik Joseph Varon Salim R Surani 

作者机构：Division of Pulmonary and Critical Care MedicineEastern Virginia Medical SchoolNorfolkVA 23507United States Department of Critical CareUnited Memorial Medical ServiceHoustonTX 77030United States Texas A and M UniversityCorpus ChristiTX 78413United States 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2020年第11卷第4期

页      面：90-94页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Diabetes Vitamin C Ascorbic acid Sepsis Thiamine Septic shock Global burden of disease 

摘      要：Sepsis and septic shock remain a major cause of morbidity and mortality among patients admitted in the intensive care unit.Diabetes is a major risk factor for the development of sepsis.The global mortality of sepsis remains high,despite significant interventions and guidelines.It has been known for decades that patients with sepsis have reduced levels of antioxidants,most notably vitamin C.Furthermore,experimental data has demonstrated multiple beneficial effects of vitamin C in sepsis.In addition,corticosteroids and thiamine may have synergistic biological effects together with vitamin C.Preliminary data suggests that therapy with hydrocortisone,ascorbic acid and thiamine improves the outcome of patients with sepsis with the potential to save millions of lives.However,this intervention has met with much resistance and has not been widely adopted.Ultimately,we await the final jury verdict on this simple,safe and cheap intervention.