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Biomedical and Environmental Sciences 2020年第9期33卷 660-669页

作者： LI Li ZHANG Bing WANG HuiJun OUYANG Yi Fei HUANG Fei Fei WANG Yun ZHANG Ji Guo SU Chang DU Wen Wen JIA Xiao Fang JIANG Hong Ru WANG Zhi Hong National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective To estimate the association between three B-vitamin intakes and sociodemographic factors among adults in China.Methods We derived our data from the China Health and Nutrition Survey(CHNS) among 12,241 individuals aged 18–64 years. Log binomial regression was used to estimate adjusted prevalence ratios for factors associated with the inadequate intake of B-vitamins.Results Females with low incomes and living in the north had a higher prevalence of inadequate riboflavin intake than those with high incomes and living in the south. Both males and females living in a village had a higher prevalence of inadequate riboflavin intake than adults living in a city. Adults with low income, low education, and living in the north or in a village had a higher prevalence of inadequate niacin intake than adults with a high income, high education, and living in the south or in a city.Conclusion We found that income, region, and area of residence were associated with riboflavin intake. Education, income, region, and area of residence were associated with niacin intake. Welltailored strategies and policies are needed to improve nutritional status in China.

关键词： Thiamine Riboflavin Niacin Vitamin B deficiency Nutritional requirements China

Hydrocortisone,vitamin C,and Thiamine may not improve the outcome of patients with sepsis or septic shock:a systematic review and meta-analysis

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Emergency and Critical Care Medicine 2023年第3期3卷 122-129页

作者： Zhuangli Li Xiaoli Zhang Yongliang Wu Chao Xie Chengjiang Liu Xiuyu He Zehua Wu Guofang Hua Yuedong Li Department of Critical Care Medicine The 901 Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation ArmyClinic CollegeAnhui Medical UniversityHefeiAnhuiChina Department of General Medicine Affiliated Anqing First People’s Hospital of Anhui Medical UniversityAnqingAnhuiChina

Background This study aimed to conduct a systematic review and meta-analysis of the efficacy of hydrocortisone,vitamin C,and Thiamine(HVT)in patients with sepsis or septic shock.Methods A literature search was performed in PubMed,Embase,Cochrane Library,and Web of Science from their inception to April 2021.Search terms included hydrocortisone,Thiamine,vitamin C,sepsis,and septic shock.Only randomized controlled trials on HVT in treating sepsis and septic shock were analyzed.Risk ratio(RR)was generated using Review Manager 5.3 to evaluate binary variants,whereas mean±standard deviation(MD)was generated to assess continuous variants.Results A total of 7 randomized controlled trials,with 1233 patients,were included in this meta-analysis.There was no significant difference in long-term mortality(35.3%vs 33.2%;RR:1.07;95%confidence interval[95%CI]:0.90-1.27;P=0.45;I^(2)=0%),intensive care unit(ICU)mortality(17.4%vs 17.5%;RR:0.99;95%CI:0.75-1.30;P=0.95;I^(2)=0%),in-hospital mortality(27.4%vs 25.8%;RR:1.06;95%CI:0.84-1.34;P=0.63;I^(2)=0%),and acute kidney injury morbidity(RR:1.04;95%CI:0.91-1.18;P=0.60;I^(2)=0%)between HVT and control groups.For continuous variables,there was no significant effect of HVT therapy on delta Sequential Organ Failure Assessment(△SOFA)score(MD:−0.44;95%CI:−1.00 to 0.12;P=0.12;I^(2)=49%),length of ICU stay(MD:0.43;95%CI:−0.27 to 1.14;P=0.23;I^(2)=0%),and length of hospital stay(MD:0.80;95%CI:−0.38 to 1.97;P=0.18;I^(2)=0%).Only vasopressor duration was significantly reduced in the HVT group(MD:−17.75;95%CI:−25.56 to−9.94;PThiamine use was not associated with improved mortality,lower acute kidney injury incidence,lower△SOFA,and shorter ICU and in-hospital stays among patients with sepsis and septic shock.

关键词： Hydrocortisone Sepsis Septic shock Thiamine Vitamin C

Biomimetic Thiamine- and niacin-decorated liposomes for enhanced oral delivery of insulin

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Acta Pharmaceutica Sinica B 2018年第1期8卷 97-105页

作者： Haisheng He Yi Lu Jianping Qi Weili Zhao Xiaochun Dong Wei Wu Key Laboratory of Smart Drug Delivery of MOE and PLA School of Pharmacy Fudan University

Biomimetic nanocarriers are emerging as efficient vehicles to facilitate dietary absorption of biomacromolecules. In this study, two vitamins, Thiamine and niacin, are employed to decorate liposomes loaded with insulin, thus facilitating oral absorption via vitamin ligand–receptor interactions. Both vitamins are conjugated with stearamine, which works to anchor the ligands to the surface of liposomes.Liposomes prepared under optimum conditions have a mean particle size of 125–150 nm and an insulin entrapment efficiency of approximately 30%–36%. Encapsulation into liposomes helps to stabilize insulin due to improved resistance against enzymatic disruption, with 60% and 80% of the insulin left after 4 h when incubated in simulated gastric and intestinal fluids, respectively, whereas non-encapsulated insulin is broken down completely at 0.5 h. Preservation of insulin bioactivity against preparative stresses is validated by intra-peritoneal injection of insulin after release from various liposomes using the surfactant Triton X-100. In a diabetic rat model chemically induced by streptozotocin, both Thiamine-and niacindecorated liposomes showed a comparable and sustained mild hypoglycemic effect. The superiority of decorated liposomes over conventional liposomes highlights the contribution of vitamin ligands. It is concluded that decoration of liposomes with Thiamine or niacin facilitates interactions with gastrointestinal vitamin receptors and thereby facilitates oral absorption of insulin-loaded liposomes.

关键词： Liposomes Vitamin Thiamine Niacin Insulin Biomimetic Oral Drug delivery

Experimental evaluation of Thiamine as a new clay swelling inhibitor

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Petroleum Science 2020年第6期17卷 1616-1633页

作者： Saeed Parvizi Ghaleh Elnaz Khodapanah Seyyed Alireza Tabatabaei-Nezhad Faculty of Petroleum and Natural Gas Engineering Sahand Oil and Gas Research InstituteSahand University of TechnologySahand New TownTabriz ***Iran

This study aims at evaluating the performance of Thiamine as a new eco-friendly shale inhibitor in water-based drilling fluids(WBDFs).The evaluation experiments include sedimentation,bentonite inhibition,filtration,zeta potential,thermal gravimetric analysis,scanning electron microscopy,X-ray diffraction,shale cuttings recovery,linear swelling and Fourier transform infrared spectroscopy(FTIR).The performance of Thiamine was compared to potassium chloride.In contrast to deionized water,the aqueous solution of Thiamine exhibited greater power to inhibit montmorillonite(Mt)dispersion,much more Mt loading capacity(280 g/L)and fluid loss,lower Mt mass loss,larger aggregated Mt particles,lower interlayer space of the Mt particles,less shale cuttings disintegration and lower linear swelling.Adsorption of Thiamine on Mt led to a significant shift in the value of zeta potential(from-17.1 to+8.54 mV).Thiamine demonstrated superior inhibitive performance than potassium chloride.FTIR analysis confirmed that Thiamine is adsorbed on Mt particles.The compatibility test revealed the compatibility of Thiamine with conventional WBDF additives.It was concluded that the main probable inhibition mechanisms of Thiamine are the cation exchange and Mt surface coating.In view of its prominent inhibition capacity and great environmental acceptability,Thiamine is a promising inhibitor for drilling in water-sensitive formations.

关键词： Shale inhibitor Thiamine Sodium bentonite Swelling Hydration Montmorillonite

Hydrocortisone, ascorbic acid and Thiamine for sepsis: Is the jury out?

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World Journal of Diabetes 2020年第4期11卷 90-94页

作者： Paul Ellis Marik Joseph Varon Salim R Surani Division of Pulmonary and Critical Care Medicine Eastern Virginia Medical SchoolNorfolkVA 23507United States Department of Critical Care United Memorial Medical ServiceHoustonTX 77030United States Texas A and M University Corpus ChristiTX 78413United States

Sepsis and septic shock remain a major cause of morbidity and mortality among patients admitted in the intensive care unit.Diabetes is a major risk factor for the development of sepsis.The global mortality of sepsis remains high,despite significant interventions and guidelines.It has been known for decades that patients with sepsis have reduced levels of antioxidants,most notably vitamin C.Furthermore,experimental data has demonstrated multiple beneficial effects of vitamin C in sepsis.In addition,corticosteroids and Thiamine may have synergistic biological effects together with vitamin C.Preliminary data suggests that therapy with hydrocortisone,ascorbic acid and Thiamine improves the outcome of patients with sepsis with the potential to save millions of lives.However,this intervention has met with much resistance and has not been widely adopted.Ultimately,we await the final jury verdict on this simple,safe and cheap intervention.

关键词： Diabetes Vitamin C Ascorbic acid Sepsis Thiamine Septic shock Global burden of disease

Can long-term Thiamine treatment improve the clinical outcomes of myotonic dystrophy type 1？

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Neural Regeneration Research 2016年第9期11卷 1487-1491页

作者： Antonio Costantini Erika Trevi Maria Immacolata Pala Roberto Fancellu Department of Neurological Rehabilitation "Villa Immacolata" Clinic Viterbo Italy School of Physiotherapy Catholic University of Rome Rome Italy Neurology Unit IRCCS San Martino University Hospital IST Genoa Italy

Myotonic dystrophy type 1, also known as Steinert＇s disease, is an autosomal dominant disorder with multisystemic clinical features affecting the skeletal and cardiac muscles, the eyes, and the endocrine system. Thiamine （vitamin B1） is a cofactor of fundamental enzymes involved in the energetic cell me- tabolism; recent studies described its role in oxidative stress, protein processing, peroxisomal function, and gene expression. Thiamine deficiency is critical mainly in the central and peripheral nervous system, as well as in the muscular cells. Our aim was to investigate the potential therapeutical effects of long-term treatment with Thiamine in myotonic dystrophy type 1 in an observational open-label pilot study. We de- scribed two patients with myotonic dystrophy type 1 treated with intramuscular Thiamine 100 mg twice a week for 12 or 11 months. We evaluated the patients using the grading of muscle strength according to Medical Research Council （MRC）, the Muscular Impairment Rating Scale （MIRS）, and the Modified Barthel index. High-dose Thiamine treatment was well tolerated and effective in improving the motor symptomatology, particularly the muscle strength evaluated with the MRC scale, and the patients＇ activi- ties of daily living using the Modified Barthel Index. At the end of treatment, the MRC score was 5 in the proximal muscles and 2-4 in the distal muscles （the MRG score before the treatment was 3-4 and 1-3, re- spectively）. The MIRS grade improved by 25% compared to baseline for both patients. In patient #1, the Modified Barthel Index improved by 44%, and in patient #2 by 29%. These findings suggest that clinical outcomes are improved by long-term Thiamine treatment.

关键词： nerve regeneration myotonic dystrophy type I Thiamine Steinert＇s disease muscular strength activity of daily living neural regeneration

Effects of Thiamine on Trichothecium and Alternaria rots of muskmelon fruit and the possible mechanisms involved

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Journal of Integrative Agriculture 2017年第11期16卷 2623-2631页

作者： GE Yong-hong LI Can-ying Lü Jing-yi ZHU Dan-shi College of Food Science and Engineering Bohai University/Food Safety Key Laboratory of Liaoning Province~National & LocalJoint Engineering Research Center of Storage Processing and Safety Control Technology for Fresh Agricultural and AquaticProducts Jinzhou 121013 P.R. China

The effects of Thiamine against pink and black spot rots caused by Trichothecium roseum and Alternaria alternata and modulation on the metabolism of reactive oxygen species （ROS） and phenylpropanoid pathway were investigated in this paper. In vitro test indicated that Thiamine significantly inhibited mycelia growth and spore germination of T. roseum and A. alternata. Thiamine at 100 mmol L-1 effectively inhibited lesion development of muskmelon fruit inoculated with T. roseum or A. alternata, enhanced production rate of O2; and H2O2 content, activities of catalase （CAT）, ascorbate peroxidase （APX） and glutathione reductase （GR） in muskmelon fruit. Thiamine also affect phenylpropanoid pathway in muskmelon fruit by increasing the activities of phenylalanine ammonia lyase （PAL） and peroxidase （POD）, the content of total phenolic compounds, flavonoids and lignin. These results suggest that the effects of Thiamine on pink and black spot rots in muskmelon fruits are associated with its direct fungitoxic against the pathogens and the modulation of O2- and H2O2 production, elimi- nating enzymes and phenylpropanoid pathway.

关键词： induced resistance Thiamine muskmelon fruit antimicrobial activity phenylpropanoid pathway

Thiamine deficiency perturbed energy metabolism enzymes in brain mitochondrial fraction of Swiss mice

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Frontiers in Biology 2017年第4期12卷 290-297页

作者： Anupama Sharma Renu Bist Surender Singh Department of Bioscience and Biotechnology Banasthali University BanasthaIL Rajasthan lndia Animal Biotechnology Centre National Dairy Research Institute Karnal India

BACKGROUND： Thiamine is an essential cofactor associated with several enzymes in energy metabolism and its deficiency may lead to neurological deficits. Current research evaluated the biochemical and molecular changes in TCA cycle enzymes using the mitochondrial fraction of the brain following Thiamine deficiency （TD） in mice. METHODS： The investigation was carried out on Swiss mice （6-8 week old） allocated into three groups. First group was control; second and third group were made Thiamine deficient for 8 and 10 days. RESULTS： Current study showed that alpha-ketoglutarate dehydrogenase （KGDHC）（Thiamine-dependent enzyme） level found to be significantly reduced in experimental groups as compared to control group. In comparison to control group, a significant decrease in the succinate dehydrogenase （SDH） activity was calculated in group II and group III （p 〈 0.0001） mice. Diminished enzymatic activity of fumarase and MDH enzyme in Thiamine deficient groups exposed for 8 and 10 days was calculated as compared to control group. The expression analysis of different genes governing TCA cycle enzymes in different experimental groups showed that there was a negotiable change in the expression of fumarase and DLD （dihydrolipoyl dehydrogenase- E3 subunit of KGDHC） whereas a declined in the expression of SDH and two subunits of KGDHC i.e. OGDH （2-oxoglutarate dehydrogenase- E1 subunit of KGDHC） and DLST （dihydrolipoyllysine-residue succinyltransferase- E2 subunit of KGDHC） was observed as compared to control group. CONCLUSIONS： Hence, current findings strongly entail that TD promotes alteration in energy metabolism in brain mitochondria which will decline the neuronal progression which may lead to neurodegenerative diseases such as Alzheimer＇s diseases.

关键词： Thiamine brain TCA cycle enzymes mitochondrial dysfunction

Normal and reverse flow injection-spectrophotometric determination of Thiamine hydrochloride in pharmaceutical preparations using diazotized metoclopramide

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Journal of Pharmaceutical Analysis 2012年第5期2卷 350-355页

作者： Mouayed Q.Al Abachi Hind Hadi Department of Chemistry College of ScienceUniversity of BaghdadJadriyahBaghdadIraq

Simple and sensitive normal and reverse flow injection methods for spectrophotometric determination of Thiamine hydrochloride （THC） at the microgram level were proposed and optimized. Both methods are based on the reaction between THC and diazotized metoclopramide in alkaline medium. Beer＇s law was obeyed over the range of 10 300 and 2-90 ug/mL, the limits of detection were 2.118 and 0.839 ug/mL and the sampling rates were 80 and 95 injections per hour for normal and reverse flow injection methods respectively. The application of both methods to commercially available pharmaceuticals produced acceptable results. The flow system is suitable for application in quality control processes.

关键词： Thiamine Metoclopramide Flow injection Spectrophotometry

Combination therapy of Thiamine,vitamin C and hydrocortisone in treating patients with sepsis and septic shock:a meta-analysis and trial sequential analysis

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Burns & Trauma 2021年第1期9卷 58-71页

作者： Renqi Yao Yibing Zhu Yue Yu Zhixuan Li Lixue Wang Liyu Zheng Jingyan Li Huibin Huang Guosheng Wu Feng Zhu Zhaofan Xia Chao Ren Yongming Yao Translational Medicine Research Center Fourth Medical Center and Medical Innovation Research Division of the Chinese PLA General HospitalBeijing 100048China Department of Burn Surgery the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Research Unit of key techniques for treatment of burns and combined burns and trauma injury Chinese Academy of Medical Sciences100730China Medical Research and Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiothoracic Surgery Changzheng HospitalNaval Medical UniversityShanghai 200003China International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200082China Department of Emergency The Second Hospital of Hebei Medical UniversityHebei 050000China Department of Critical Care Medicine Beijing Tsinghua Chang Gung HospitalBeijing 102218China Medical ICU Peking Union Medical College HospitalPeking Union Medical College Chinese Academy of Medical Sciences Beijing 100730China and 10Department of Critical Care MedicineShanghai East HospitalTongji University School of MedicineShanghai 200120China

Background:The objective of this study was to evaluate the clinical efficacy of Thiamine and vitamin C with or without hydrocortisone coadministration on the treatment of sepsis and septic shock.Methods:MEDLINE,EMBASE and CENTRAL databases were searched for randomized controlled trials(RCTs)that made a comparative study between the combination therapy of vitamin C and Thiamine with or without hydrocortisone and the administration of placebo in patients with sepsis or septic shock.Two reviewers independently performed study selection,data extraction and quality assessment.Both short-term mortality and change in the sequential organ failure assessment(SOFA)score from baseline(delta SOFA)were set as the primary outcomes.Secondary endpoints included intensive care unit(ICU)mortality,new onset of acute kidney injury,total adverse events,ICU and hospital length of stay,duration of vasopressor usage and ventilator-free days.Meanwhile,trial sequential analysis was conducted for primary outcomes.Results:Eight RCTs with 1428 patients were included in the current study.The results showed no significant reduction of short-term mortality in sepsis and septic shock patients who received combination therapy of vitamin C and Thiamine with or without hydrocortisone compared to those with placebo{risk ratio(RR),1.02[95%confidence interval(CI),0.87 to 1.20],p=0.81,I2=0%;risk difference(RD),0[95%CI,−0.04 to 0.05]}.Nevertheless,the combination therapy was associated with significant reduction in SOFA score[mean difference(MD),−0.63,(95%CI,−0.96 to−0.29,pThiamine,with or without hydrocortisone had no impact on short-term mortality when compared with placebo,but was associated with significant reduction in SOFA score among patients with sepsis and septic shock.

关键词： Thiamine Vitamin C Sepsis Septic shock Sequential organ failure assessment Meta-analysis