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Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos

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Journal of Environmental Sciences 2024年第5期139卷 460-472页

作者： Sujie Sun Li Zhang Xue Li Lu Zang Ling Huang Junquan Zeng Zigang Cao Xinjun Liao Zilin Zhong Huiqiang Lu Jianjun Chen Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases Jiangxi Key Laboratory of Developmental Biology of OrgansCenter for Clinical Research Center of the Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationDepartment of PediatricsShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Sciences and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Interventional and Vascular Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Department of Internal Medicine and Hematology Affiliated Hospital of Jinggangshan UniversityJi’an 343009China

As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water environments.However,little is known regarding its toxic effects on cardiovascular development.Here,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/L HFPO-TA.Results showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart rate.Furthermore,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(SV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart looping.Obvious sprouting angiogenesis was observed in the 120 and 240 mg/L exposed Tg(fli:GFP)transgenic larvae.HFPO-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular development.HFPO-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism pathway.HFPO-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting apoptosis.Therefore,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA.

关键词： Hexafluoropropylene oxide trimer acid Heart development Vascular development Hemopoiesis Zebrafish embryos

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Leaching process of phosphorus and iron from steelmaking slag into malic acid solution

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Journal of Iron and Steel Research(International) 2022年第6期29卷 951-960页

作者： Ning-ning Lv Chang Su Hui Kong Hai-chuan Wang Yuan-chi Dong Key Laboratory of Metallurgical Emission Reduction and Resources Recycling Ministry of EducationAnhui University of TechnologyMa’anshan 243002AnhuiChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina

In order to remove phosphorus element from steelmaking slag and decrease iron loss,malic acid was selected as the leaching agent to dissolve steelmaking slag.Firstly,the influences of different factors,such as malic acid concentration,slag particle size,temperature,liquid/solid ratio and stirring speed,on the leaching ratios of phosphorus and iron were studied.Then,the kinetics for the leaching process of phosphorus was analyzed.The results showed that the leaching ratios of phosphorus and iron increase significantly with increasing the malic acid solution concentration and liquid/solid ratio.When the concentration of malic acid solution increases up to 0.01492 mol/L,about 80%phosphorus can be dissolved,and iron leaching ratio is less than 17%.In addition,decreasing slag particle size can obviously increase the leaching ratio of phosphorus.However,temperature and stirring speed have no significant effect on the dissolution of phosphorus and iron.The leaching kinetics of phosphorus follows the unreacted shrinking core model.Diffusion through product layer is the rate-limiting step of the leaching process,and the corresponding apparent activation energy is determined to be 3.32 kJ/mol.Finally,a semi-empirical kinetic equation was established.

关键词： Leaching process Steelmaking slag Phosphorus Iron Malic acid solution

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Effect of AMPS(2-acrylamido-2-methylpropane sulfonic acid) content on the properties of polymer gels

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Petroleum Science 2022年第2期19卷 697-706页

作者： Tian-Ci Zhang Ji-Jiang Ge Hao Wu Hong-Bin Guo Bao-Lei Jiao Zhen Qian School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Petroleum Engineering Institute Northwest Branch of SinopecUrumqi830011XinjiangChina

The BST oilfield in the northwestern Taklamakan Desert is a fractured carbonate reservoir,but issues of water breakthrough are becoming increasingly severe with the development of water flooding.Unfortunately,the high-temperature and high-salt conditions(130°C,71695 mg/L)of the BST oilfield pose challenges for the development of plugging agents.In this study,the effects of 2-acrylamido-2-methylpropane sulfonic acid(AMPS)content on AM/AMPS copolymers and gels were studied through viscosity measurements,nuclear magnetic resonance(NMR),and cryo-scanning electron microscope(Cryo-SEM).Moreover,the AMPS stabilization mechanism of the polymers and gels was explained.Heatresistant and salt-tolerant gel systems were developed,and their gelation properties,thermal stability,injection capacity,and plugging ability were evaluated.Experimental results showed inconsistencies between the effects of AMPS content on the polymers and gels.For the polymers,the thermal stability increased with increased AMPS content in the polymer.However,excessive AMPS content resulted in poor gelation and low strength.The developed gel systems with S30 polymer(AMPS content is approximately 26%)exhibited excellent thermal stability,controllable gelation time,good injection capacity,and plugging ability.The field application results indicated that most production wells had a positive response,with reduced water-cut and increased daily oil production.

关键词： Gels 2-Acrylamido-2-methylpropane sulfonic acid Enhanced oil recovery Hydrolysis Syneresis

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Multi?targeted Antisense Oligonucleotide Delivery by a Framework Nucleic acid for Inhibiting Biofilm Formation and Virulence

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Nano-Micro Letters 2020年第6期12卷 113-125页

作者： Yuxin Zhang Xueping Xie Wenjuan Ma Yuxi Zhan Chenchen Mao Xiaoru Shao Yunfeng Lin State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041People’s Republic of China

Biofilm formation is responsible for numerous chronic infections and represents a serious health challenge.Bacteria and the extracellular polysaccharides(EPS)cause biofilms to become adherent,toxic,resistant to antibiotics,and ultimately difficult to remove.Inhibition of EPS synthesis can prevent the formation of bacterial biofilms,reduce their robustness,and promote removal.Here,we have developed a framework nucleic acid delivery system with a tetrahedral configuration.It can easily access bacterial cells and functions by delivering antisense oligonucleotides that target specific genes.We designed antisense oligonucleotide sequences with multiple targets based on conserved regions of the VicK protein-binding site.Once delivered to bacterial cells,they significantly decreased EPS synthesis and biofilm thickness.Compared to existing approaches,this system is highly efficacious because it simultaneously reduces the expression of all targeted genes(gtfBCD,gbpB,ftf).We demonstrate a novel nucleic acid-based nanomaterial with multi-targeted inhibition that has great potential for the treatment of chronic infections caused by biofilms.

关键词： Biofilm Framework nucleic acid Multi-targeting Antisense oligonucleotide Delivery system

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Oxygen tension modulates cell function in an in vitro three-dimensional glioblastoma tumor model

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BIO-DESIGN AND MANUFACTURING 2024年第3期7卷 307-319页

作者： Wang, Sen Yao, Siqi Pei, Na Bai, Luge Hao, Zhiyan Li, Dichen He, Jiankang Oliveira, J. Miguel Xue, Xiaoyan Wang, Ling Mao, Xinggang Xi An Jiao Tong Univ State Key Lab Mfg Syst Engn Xian 710054 Peoples R China Xi An Jiao Tong Univ Sch Mech Engn Xian 710054 Peoples R China Xi An Jiao Tong Univ NMPA Key Lab Res & Evaluat Addit Mfg Med Devices Xian 710054 Peoples R China Univ Minho Res Grp 3Bs Res Inst Biomat Biodegradables & Biomimet I3Bs Headquarters European Inst Excellence Tissue Engn Avepk Zona Ind Gandra P-4805017 Guimaraes Portugal ICVS 3Bs PT Govt Associate Lab P-4806909 Guimaraes Portugal Fourth Mil Med Univ Sch Pharm Dept Pharmacol Xian 710032 Peoples R China Fourth Mil Med Univ Xijing Hosp Dept Neurosurg Xian 710032 Peoples R China

Hypoxia is a typical feature of the tumor microenvironment, one of the most critical factors affecting cell behavior and tumor progression. However, the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells. This study reports a three-dimensional (3D) brain tumor model obtained by encapsulating U87MG (U87) cells in a hydrogel containing type I collagen. It also documents the effect of various oxygen concentrations (1%, 7%, and 21%) in the culture environment on U87 cell morphology, proliferation, viability, cell cycle, apoptosis rate, and migration. Finally, it compares two-dimensional (2D) and 3D cultures. For comparison purposes, cells cultured in flat culture dishes were used as the control (2D model). Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase (G0 phase)/gap I phase (G1 phase) than those cultured in the 2D model. Besides, the two models yielded significantly different cell morphologies. Finally, hypoxia (e.g., 1% O2) affected cell morphology, slowed cell growth, reduced cell viability, and increased the apoptosis rate in the 3D model. These results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function, and can be more representative of the tumor microenvironment than 2D culture systems. The developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.

关键词： Hypoxia Glioma Three-dimensional glioma model In vitro CULTURE-SYSTEM GLIOMA HYPOXIA acid DRUG HETEROGENEITY PROGRESSION INVASION STEMNESS MAINTAIN

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Achieving a superior Na storage performance of Fe-based Prussian blue cathode by coating perylene tetracarboxylic dianhydride amine

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CARBON ENERGY 2024年第5期6卷 53-64页

作者： Fu, Xin-Yuan Zhang, Lu-Lu Chen, Zhao-Yao Xu, Yunkai Wu, Junxiu Wang, Cheng-Cheng Ding, Xiao-Kai Yang, Xue-Lin Lu, Jun China Three Gorges Univ Coll Elect Engn & New Energy Hubei Prov Collaborat Innovat Ctr New Energy Micro Yichang Hubei Peoples R China China Three Gorges Univ Coll Elect Engn & New Energy Hubei Prov Collaborat Innovat Ctr New Energy Micro Yichang 443002 Hubei Peoples R China China Three Gorges Univ Coll Mat & Chem Engn Yichang Hubei Peoples R China Zhejiang Univ Coll Chem & Biol Engn Hangzhou Peoples R China Zhejiang Univ Coll Chem & Biol Engn Hangzhou 310058 Peoples R China

Fe-based Prussian blue (Fe-PB) cathode material shows great application potential in sodium (Na)-ion batteries due to its high theoretical capacity, long cycle life, low cost, and simple preparation process. However, the crystalline water and vacancies of Fe-PB lattice, the low electrical conductivity, and the dissolution of metal ions lead to limited capacity and poor cycling stability. In this work, a perylene tetracarboxylic dianhydride amine (PTCDA) coating layer is successfully fabricated on the surface of Fe-PB by a liquid-phase method. The aminated PTCDA (PTCA) coating not only increases the specific surface area and electronic conductivity but also effectively reduces the crystalline water and vacancies, which avoids the erosion of Fe-PB by electrolyte. Consequently, the PTCA layer reduces the charge transfer resistance, enhances the Na-ion diffusion coefficient, and improves the structure stability. The PTCA-coated Fe-PB exhibits superior Na storage performance with a first discharge capacity of 145.2 mAh g-1 at 100 mA g-1. Long cycling tests exhibit minimal capacity decay of 0.027% per cycle over 1000 cycles at 1 A g-1. Therefore, this PTCA coating strategy has shown promising competence in enhancing the electrochemical performance of Fe-PB, which can potentially serve as a universal electrode coating strategy for Na-ion batteries. Perylene tetracarboxylic dianhydride amine layer has been successfully covered on the Fe-based Prussian blue (Fe-PB) surface for the first time, which increases the specific surface area and reduces crystal water with vacancies. Also, the coating layer enhances the transport ability of sodium ions with enhanced electronic conductivity, while inhibiting the dissolution of metal ions of electrodes. As a result, the as-synthesized Fe-PB have shown excellent cycling stability and impressive high capacity as sodium-ion battery cathodes. image

关键词： cathode material coating Fe-based Prussian blue Na-ion batteries perylene tetracarboxylic dianhydride amine ELECTROCHEMICAL PERFORMANCE ION ANALOGS TRANSITION acid

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Cellular interplay to 3D in vitro microphysiological disease model: cell patterning microbiota-gut-brain axis

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BIO-DESIGN AND MANUFACTURING 2024年第3期7卷 320-357页

作者： Alam, Kamare Nair, Lakshmi Mukherjee, Souvik Kaur, Kulwinder Singh, Manjari Kaity, Santanu Ravichandiran, Velayutham Banerjee, Sugato Roy, Subhadeep Natl Inst Pharmaceut Educ & Res Dept Pharmacol & Toxicol Kolkata 700054 West Bengal India Natl Inst Pharmaceut Educ & Res Dept Pharmaceut Kolkata 700054 West Bengal India Natl Inst Pharmaceut Educ & Res Dept Nat Prod Kolkata 700054 West Bengal India Assam Univ Dept Pharmaceut Sci Silchar 788011 India Guru Ghasidas Univ Dept Pharmaceut Sci Bilaspur 495009 Chhattisgarh India RCSI Univ Med & Hlth Sci Sch Pharm & Biomol Sci RCSI Dublin D02YN77 Ireland RCSI Univ Med & Hlth Sci Dept Anat & Regenerat Med Tissue Engn Res Grp Dublin D02 YN77 Ireland

The microbiota-gut-brain axis (MGBA) has emerged as a key prospect in the bidirectional communication between two major organ systems: the brain and the gut. Homeostasis between the two organ systems allows the body to function without disease, whereas dysbiosis has long-standing evidence of etiopathological conditions. The most common communication paths are the microbial release of metabolites, soluble neurotransmitters, and immune cells. However, each pathway is intertwined with a complex one. With the emergence of in vitro models and the popularity of three-dimensional (3D) cultures and Transwells, engineering has become easier for the scientific understanding of neurodegenerative diseases. This paper briefly retraces the possible communication pathways between the gut microbiome and the brain. It further elaborates on three major diseases: autism spectrum disorder, Parkinson's disease, and Alzheimer's disease, which are prevalent in children and the elderly. These diseases also decrease patients' quality of life. Hence, understanding them more deeply with respect to current advances in in vitro modeling is crucial for understanding the diseases. Remodeling of MGBA in the laboratory uses many molecular technologies and biomaterial advances. Spheroids and organoids provide a more realistic picture of the cell and tissue structure than monolayers. Combining them with the Transwell system offers the advantage of compartmentalizing the two systems (apical and basal) while allowing physical and chemical cues between them. Cutting-edge technologies, such as bioprinting and microfluidic chips, might be the future of in vitro modeling, as they provide dynamicity.

关键词： Microbiota-gut-brain axis Neurodegeneration 3D disease model Organoid Transwell system PLURIPOTENT STEM-CELLS ALZHEIMERS-DISEASE PARKINSONS-DISEASE SODIUM-BUTYRATE MOUSE MODEL RECEPTOR 2 BACTERIA acid CULTURE IMMUNE

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Atomically dispersed Mn-Nx catalysts derived from Mn-hexamine coordination frameworks for oxygen reduction reaction

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CARBON ENERGY 2024年第5期6卷 114-126页

作者： Zhong, Guoyu Zou, Liuyong Chi, Xiao Meng, Zhen Chen, Zehong Li, Tingzhen Huang, Yongfa Fu, Xiaobo Liao, Wenbo Zheng, Shaona Xu, Yongjun Peng, Feng Peng, Xinwen Dongguan Univ Technol Sch Chem Engn & Energy Technol Guangdong Prov Key Lab Distributed Energy Syst Dongguan 523808 Peoples R China South China Univ Technol State Key Lab Pulp & Paper Engn Guangzhou 510641 Peoples R China Natl Univ Singapore Ctr Adv 2D Mat CA2DM Dept Chem Singapore Singapore Guangzhou Univ Sch Chem & Chem Engn Guangzhou Peoples R China

Metal-organic frameworks recently have been burgeoning and used as precursors to obtain various metal-nitrogen-carbon catalysts for oxygen reduction reaction (ORR). Although rarely studied, Mn-N-C is a promising catalyst for ORR due to its weak Fenton reaction activity and strong graphitization catalysis. Here, we developed a facile strategy for anchoring the atomically dispersed nitrogen-coordinated single Mn sites on carbon nanosheets (MnNCS) from an Mn-hexamine coordination framework. The atomically dispersed Mn-N-4 sites were dispersed on ultrathin carbon nanosheets with a hierarchically porous structure. The optimized MnNCS displayed an excellent ORR performance in half-cells (0.89 V vs. reversible hydrogen electrode (RHE) in base and 0.76 V vs. RHE in acid in half-wave potential) and Zn-air batteries (233 mW cm(-2) in peak power density), along with significantly enhanced stability. Density functional theory calculations further corroborated that the Mn-N-4-C-12 site has favorable adsorption of *OH as the rate-determining step. These findings demonstrate that the metal-hexamine coordination framework can be used as a model system for the rational design of highly active atomic metal catalysts for energy applications.

关键词： carbon nanosheets electrocatalyst metal-organic frameworks Mn-N-4 oxygen reduction reaction Zn-air batteries METAL-ORGANIC FRAMEWORK DOPED POROUS CARBON EFFICIENT ELECTROCATALYST NITRATE COMPLEXES ACTIVE-SITES IRON ORIGIN HEXAMETHYLENETETRAMINE ATOMS acid

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Effects of synthesis parameters on the performance of crosslinked Co-polymers with clays for conformance control

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PETROLEUM RESEARCH 2024年第1期9卷 98-108页

作者： Roslan, A. A. Aziz, N. A. A. Deraman, N. F. A. Dzulkarnain, I. Univ Teknol PETRONAS Ctr Res Enhanced Oil Recovery COREOR Petr Engn Dept Seri Iskandar Perak Malaysia Univ Teknol PETRONAS Ctr Res Enhanced Oil Recovery COREOR Chem Engn Dept Seri Iskandar Perak Malaysia

Conformance control or water shut-off is a technique used to improve oil recovery. During conformance control, polymers block high permeability water areas and redistribute water drive toward unswept oil zones. In this study, co-polymers (denoted ATP-PGV/AM-co-AMPS) were synthesized using acrylamide (AM) and 2-acrylamide-2-methylpropane sulfonic acid (AMPS) as the monomers, polyethylene glycol (PEG)-20 0 and methylenebisacrylamide (MBA) as the crosslinkers, attapulgite (ATP) and bentonite (PGV) as the clay types, and ammonium persulfate (APS) as the initiator, in addition to paraffin oil and surfactants. Samples were synthesized using inverse emulsion polymerization with different concentrations of monomers, crosslinkers, and clays, and they were characterized using Fourier-transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX). FTIR spectra of the samples confirmed the existence of sulfonate and hydroxyl groups, which are important for polymer swelling. SEM-EDX images indicated that the morphology and elemental composition were different before and after swelling, confirming the occurrence of swelling. Moreover, samples were placed in sodium chloride solution (20,000 ppm) for 7 days to evaluate swelling at both room temperature and 90 degrees C. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to determine the thermal characteristics of the microparticles. Finally, rheological measurements were used to assess the deformation and rheological behavior of the hydrogels. The results showed that after 1 day, good swelling without loss of mechanical strength was achieved with the composite synthesized using 10% AM, 15% AMPS, 6% PGV, and 10% ATP. (c) 2023 The Authors. Publishing services provided by Elsevier B.V. on behalf of KeAi Communication Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://***/licenses/ by-nc-nd/4.0/).

关键词： Polymer Clay Water shut-off Conformance Swelling HIGHLY SWOLLEN DYE SORPTION COMPOSITE HYDROGEL EMULSION acid

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acid precipitation coupled electrodialysis to improve separation of chloride and organics in pulping crystallization mother liquor

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Chinese Journal of Chemical Engineering 2019年第12期27卷 2917-2924页

作者： Zhaoyang Li Rongzong Li Zhaoxiang Zhong Ming Zhou Min Chen Weihong Xing State Key Laboratory of Materials-Oriented Chemical Engineering National Engineering Research Center for Special Separation MembraneNanjing Tech UniversityNanjing 211816China

Inefficient separation of inorganic salts and organic matters in crystallization mother liquor is still a problem to industrial wa stewater treatment since the high salinity significantly impedes organic pollutant degradation by oxidation or incineration.In the study,acidification combined electrodialysis(ED)was attempted to effectively separate Cl-ions from organics in concentrate pulping wastewater.Membrane’s rejection rate to total organic carbon(TOC)was 85%at wastewater intrinsic pH=9.8 and enhanced to 93%by acidifying it to pH=2 in ED process.Negative-charged alkaline organic compounds(mainly lignin)could be liberated from their sodium salt forms and coagulated in acidification pretreatment.Neutralization of the organic substances also made their electro-migration less effective under electric driving force and in particular improved separation efficiency of chloride and organics.After acid-ED coupled treatment(pH=2 and J=40 mA·cm-2)[TOC]remarkably reduced from 1.315 g·L-1 to 0.048 g·L-1 and[Cl-]accumulated to 130 g·L-1 in concentrate solution.Recovery rate of NaCl was 89%and the power consumption was 0.38 kW·h·kg-1 NaCl.Irreversible fouling was not caused as electric resistance of membrane pile maintained stably.In conclusion,acidic-ED is a practical option to treat salinity organic wastewater when current techniques including thermal evaporation and pressure-driven membrane se paration present limitations.

关键词： Crystallization mother liquor acid precipitation Electrodialysis Chloride recovery

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