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Calcium silicate accelerates cutaneous wound healing with enhanced re-epithelialization through EGF/EGFR/ERK-mediated promotion of epidermal stem cell functions

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Burns & Trauma 2021年第1期9卷 184-195页

作者： Bingmin Li Haowen Tang Xiaowei Bian Kui Ma Jiang Chang Xiaobing Fu Cuiping Zhang Research center for tissue repair and regeneration affiliated to the Medical innovation Research Division and Fourth Medical center of Chinese PLA General Hospital 100048BeijingChina Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences100048BeijingChina Department of Dermatology Fourth Medical Center of Chinese PLA General Hospital100048BeijingChina Faculty of Hepato-Biliary-Pancreatic Surgery Chinese PLA General Hospital100853BeijingChina Shanghai Institute of Ceramics Chinese Academy of Sciences200050ShanghaiChina

Background:Human epidermal stem cells(hESCs)play an important role in re-epithelialization and thereby in facilitating wound healing,while an effective way to activate hESCs remains to be *** silicate(CS)is a form of bioceramic that can alter cell behavior and promote tissue ***,we have observed the effect of CS on hESCs and investigated its possible ***:Using a mouse full-thickness skin excision model,we explored the therapeutic effect of CS on wound healing and *** vitro,hESCs were cultured with diluted CS ion extracts(CSIEs),and the proliferation,migration ability and stemness of hESCs were *** effects of CS on the epidermal growth factor(EGF),epidermal growth factor receptor(EGFR)and extracellular signal-related kinase(ERK)signaling pathway were also ***:In vivo,CS accelerated wound healing and *** demonstrated that CS upregulated cytokeratin 19 and integrinβ1 expression,indicating that CS improved hESCs *** vitro studies confirmed that CS improved the biological function of *** the possible mechanism could be due to the activation of the EGF/EGFR/ERK signaling ***:CS can promote re-epithelialization and improve the biological functions of hESCs via activating the EGF/EGFR/ERK signaling pathway.

关键词： bioceramic calcium silicate epidermal stem cells re-epithelialization wounds

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Human adipose tissue-and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?

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Neural regeneration Research 2020年第12期15卷 2306-2317页

作者： Ai-Mei Liu Bo-Li Chen Ling-Tai Yu Tao Liu Ling-Ling Shi Pan-Pan Yu Yi-Bo Qu Kwok-Fai So Li-Bing Zhou Guangdong-Hongkong-Macao Institute of CNS regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Guangzhou Regenerative medicine and Health Guangdong Laboratory GuangzhouGuangdong ProvinceChina Co-innovation center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

Multiple types of stem cells have been proposed for the treatment of spinal cord injury,but their comparative information remains *** this study,a rat model of T10 contusion spinal cord injury was established by the impactor *** umbilical cord-derived mesenchymal stem cells(UCMSCs)or human adipose tissue-derived mesenchymal stem cells(ADMSCs)(2.5μL/injection site,1×10^5 cells/μL)was injected on rostral and caudal of the injury segment on the ninth day after *** injected with mesenchymal stem cell culture medium were used as *** results show that although transplanted UCMSCs and ADMSCs failed to differentiate into neurons or glial cells in vivo,both significantly improved motor and sensory *** spinal cord injury,UCMSCs and ADMSCs similarly promoted spinal neuron survival and axonal regeneration,decreased glial scar and lesion cavity formation,and reduced numbers of active *** analysis of spinal samples showed a specific increase of interleukin-10 and decrease of tumor necrosis factorαin the ADMSC group,as well as a downregulation of macrophage inflammatory protein 3αin both UCMSC and ADMSC groups at 3 days after cell *** of interleukin-10 and interleukin-13 was observed in both UCMSC and ADMSC groups at 7 days after cell *** tagging for relative and absolute quantitation proteomics analyses showed that UCMSCs and ADMSCs induced changes of multiple genes related to axonal regeneration,neurotrophy,and cell apoptosis in common and specific *** conclusion,UCMSC and ADMSC transplants yielded quite similar contributions to motor and sensory recovery after spinal cord injury via anti-inflammation and improved axonal ***,there were some differences in cytokine and gene expression induced by these two types of transplanted *** experiments were approved by the Laboratory Animal Ethics Committee at Jinan University(approval No.20180228026)on Febru

关键词： behavior central nervous system factor inflammation model spinal cord stem cells transplantation

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3D-printable supramolecular hydrogels with shear-thinning property: fabricating strength tunable bioink via dual crosslinking

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Bioactive Materials 2020年第4期5卷 808-818页

作者： Tian Hu Xiaoliang Cui Meng Zhu Man Wu Ye Tian Bin Yao Wei Song Zhongwei Niu Sha Huang Xiaobing Fu Research center for tissue repair and regeneration Affiliated to the Medical innovation Research Department PLA General Hospital and PLA Medical College28 Fu Xing RoadBeijing100853PR China PLA Key Laboratory of tissue repair and Regenerative medicine and Beijing Key Research Laboratory of Skin Injury Repair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU05151 Fu Cheng RoadBeijing100048PR China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Chinese Academy of Medical Sciences(CAMS)Oxford Institute Nuffield Department of MedicineUniversity of OxfordOxford OX39DSUK School of Future Technology University of Chinese Academy of SciencesBeijing100049PR China

3-dimensional(3D)bioprinting technology provides promising strategy in the fabrication of artificial tissues and *** the fundamental element in bioprinting process,preparation of bioink with ideal mechanical properties without sacrifice of biocompatibility is a great *** this study,a supramolecular hydrogel-based bioink is prepared by polyethylene glycol(PEG)grafted chitosan,α-cyclodextrin(α-CD)and *** has a primary crosslinking structure through the aggregation of the pseudo-polyrotaxane-like side chains,which are formed from the host-guest interactions betweenα-CD and PEG side *** viscosity measurement shows the shear-shinning property of this bioink,which might be due to the reversibility of the physical ***,withβ-glycerophosphate at different concentrations as the secondary crosslinking agent,the printed constructs demonstrate different Young's modulus(ptissues and organs.

关键词： Supramolecular hydrogel Bioink Tunable strength 3D bioprinting

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Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation

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Nano Research 2023年第12期16卷 13259-13266页

作者： Lijuan Tang Zhenghan Di Jingfang Zhang Feiying Yin Lele Li Li Zheng Guangxi Key Laboratory of Regenerative medicine Guangxi Engineering Center in Biomedical Material for Tissue and Organ RegenerationCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development nd Application Co-Constructed by the Province and MinistryThe First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Pharmaceutical College Guangxi Medical UniversityNanning 530021China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

Developing dedicated nanomedicines to improve delivery efficacy of anti-inflammatory drugs is still a formidable *** this study,we present an extremely simple yet efficient approach to obtain hybrid nanodrugs through metal-drug coordination-driven self-assembly for carrier-free drug *** resulting metallo-nanodrugs exhibit well-defined morphology and high drug encapsulation capability,allowing for the combination of magnetic resonance imaging and anti-inflammatory *** the case of osteoarthritis(OA),the metallo-nanodrugs remarkably alleviate synovial inflammation,preventing cartilage destruction and extracellular matrix *** addition,it led to significantly improved therapeutic efficacy compared with intra-articular administration of the same dose of free drugs in OA mouse *** work provides a very simple approach for the development of anti-inflammatory nanoformulations by exploiting coordination-driven self-assembly.

关键词： drug delivery coordination-driven assembly nanomedicine anti-inflammation therapy

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Sebaceous gland reprogramming with a single gene, PPARG, and small molecules

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3913-3916页

作者： Yiqiong Liu Shuaifei Ji Huanhuan Gao Huating Chen Jiangbing Xiang Shaoyuan Cui Christos CZouboulis Aizhen Cai Xiaobing Fu Xiaoyan Sun Research center for tissue repair and regeneration affiliated to the Medical innovation Research Department and 4th Medical center PLA General Hospital and PLA Medical CollegePLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin InjuryRepairand RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051100048 BeijingP.R.China Department of Nephrology The First Medical CenterChinese PLA General HospitalState Key Laboratory of Kidney Diseases100048 BeijingChina Departments of Dermatology VenereologyAllergologyand ImmunologyStaedtisches Klinikum DessauBrandenburg Medical School Theodor Fontane and Faculty of Health Sciences BrandenburgDessauGermany Institute of General Surgery Department of General Surgerythe 1st Medical CenterPLA General Hospital28 Fu Xing Road100853 BeijingP.R.China

Dear Editor,Sebaceous glands(SG)contribute to 90%of the skin surface lipid production and play critical roles in regulating proper skin functions including epidermal barrier maintenance,dermal immune responses,and global body anti-microbial activities.1 Reduced sebaceous lipid has been implicated in diverse skin diseases,including scarring alopecia,inflammation,chronic itch,as well as premature aging of the skin.2 Especially,scar repair after deep burns or large-scale skin defect often leads to irreversible loss of *** to lacking SG,the regenerated tissues cannot fully recapitulate the structural and functional integrity of normal ***,generation of expandable SG cells with developmental and lipid-producing potentials represents a promising approach for treating diseased,damaged,or aged skin with better quality of ***,direct cellular reprogramming has been widely used for obtaining difficult-to-maintain human cells by cell type-specific transcription factors(TFs).

关键词： programming maintain irreversible

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Proteolysis targeting chimera technology:a novel strategy for treating diseases of the central nervous system

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Neural regeneration Research 2021年第10期16卷 1944-1949页

作者： Ke Ma Xiao-Xiao Han Xiao-Ming Yang Song-Lin Zhou Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina College of Life Science Nantong UniversityNantongJiangsu ProvinceChina

Neurological diseases such as stroke,Alzheimer’s disease,Parkinson’s disease,and Huntington’s disease are among the intractable diseases for which appropriate drugs and treatments are *** targeting chimera(PROTAC)technology is a novel strategy to solve this *** technology uses the ubiquitin-protease system to eliminate mutated,denatured,and harmful proteins in *** can be reused,and utilizes the protein destruction mechanism of the cells,thus making up for the deficiencies of traditional protein degradation *** can effectively target and degrade proteins,including proteins that are difficult to identify and ***,it has extremely important implications for drug development and the treatment of neurological *** present,the targeted degradation of mutant BTK,mHTT,Tau,EGFR,and other proteins using PROTAC technology is gaining *** is expected that corresponding treatment of nervous system diseases can be *** review first focuses on the recent developments in PROTAC technology in terms of protein degradation,drug production,and treatment of central nervous system diseases,and then discusses its *** review will provide a brief overview of the recent application of PROTAC technology in the treatment of central nervous system diseases.

关键词： Alzheimer’s disease disease treatment drug development Huntington’s disease proteolysis targeting chimera stroke targeted degradation

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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research center of Stem Cells Translational medicine ShanghaiChina National center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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White-light-induced synthesis of injectable alginate-based composite hydrogels for rapid hemostasis

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Military Medical Research 2024年第5期11卷 785-788页

作者： Meng-De Zhang Xing Huang Zhao Li Wei Song Yi Kong Chao Zhang Li-Ting Liang Yu-Yan Huang Ya-Xin Tan Yu Feng Qing-Hua Liu Yu-Xia Zhao Xiao-Bing Fu Sha Huang Research center for tissue repair and regeneration Affiliated to the Medical innovation Research Department PLA General Hospital and PLA Medical CollegeBeijing100853China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China

Dear Editor,Timely and effective hemostasis is of great significance for reducing body damage and mortality of patients [1]. Alginate is generally considered to be an excellent hemostatic polymer-based biomaterial and has been approved by the Food and Drug Administration as Generally Recognized as Safe [2]. However, the violent crosslinking reaction and unstable structure at the wound site limit its clinical applications. Hence, we report a biocompatible and injectable composite hydrogel methacrylate alginate (Alg-AEMA)-based Eosin Y/N-phenylglycine (NPG)-initiated composite hydrogel (AEC) composed of photocrosslinkable alginate, viscosity modifiers and novel white light photoinitiator, namely Eosin Y/NPG system, for instant hemorrhage control.

关键词： Photoinitiator Photopolymerization Alginate Hydrogel Hemostasis

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Application of stem cells in peripheral nerve regeneration

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Burns & Trauma 2020年第1期8卷 407-416页

作者： Sheng Yi Yu Zhang Xiaokun Gu Li Huang Kairong Zhang Tianmei Qian Xiaosong Gu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-innovation Center of NeuroregenerationNantong UniversityNantongJiangsuChina Nuclear medicine Department Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsuChina

Traumatic peripheral nerve injury is a worldwide clinical issue with high *** severity of peripheral nerve injury can be classified as neurapraxia,axonotmesis or neurotmesis,according to Seddon’s classification,or five different degrees according to Sunderland’s *** with neurotmesis suffer from a complete transection of peripheral nerve stumps and are often in need of surgical repair of nerve *** applications of autologous nerve grafts as the golden standard for peripheral nerve transplantation meet some difficulties,including donor nerve sacrifice and nerve *** have been made to construct tissue-engineered nerve grafts as supplements or even substitutes for autologous nerve grafts to bridge peripheral nerve *** incorporation of stem cells as seed cells into the biomaterial-based scaffolds increases the effectiveness of tissue-engineered nerve grafts and largely boosts the regenerative *** stem cells,including embryonic stem cells,neural stem cells,bone marrow mesenchymal stem cells,adipose stem cells,skin-derived precursor stem cells and induced pluripotent stem cells,have been used in neural tissue *** the current review,recent trials of stem cell-based tissue-engineered nerve grafts have been summarized;potential concerns and perspectives of stem cell therapeutics have also been contemplated.

关键词： Peripheral nerve injury tissue-engineered nerve grafts Seed cells Stem cells Peripheral nerve regeneration

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In situ forming injectable MSC-loaded GelMA hydrogels combined with PD for vascularized sweat gland regeneration

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Military Medical Research 2024年第1期11卷 152-155页

作者： Enhe Jirigala Bin Yao Zhao Li Yi-Jie Zhang Chao Zhang Li-Ting Liang Fan-Liang Zhang Xing-Yu Yuan Xian-Lan Duan Wei Song Meng-De Zhang Yi Kong Xiao-Bing Fu Sha Huang Research center for tissue repair and regeneration Medical Innovation Research DepartmentChinese PLA General Hospital and PLA Medical CollegeBeijing 100048China Institute of Basic Medical Research Inner Mongolia Medical UniversityHohhot 010110China Academy of Medical Engineering and Translational medicine Tianjin UniversityTianjin 300072China School of medicine Nankai UniversityTianjin 300071China

Dear Editor,Three dimensional(3D)bioprinted extracellular matrix(ECM)can be used to provide both biochemical and biophysical cues to direct mesenchymal stem cells(MSCs)differentiation,and then differentiated cells were isolated for implantation in vivo using surgical ***,the reduced cell activity after cell isolation from 3D constructs and low cell retention in injured sites limit its application[1].Methacrylated gelatin(GelMA)hydrogel has the advantage of fast crosslinking,which could resemble complex architectures of tissue construct in vivo[2].Here,we adopted a noninvasive bioprinting procedure to imitate the regenerative microenvironment that could simultaneously direct the sweat gland(SG)and vascular differentiation from MSCs and ultimately promote the replacement of glandular tissue in situ(Fig.1a).

关键词： Sweat gland GelMA In situ niche Cell differentiation tissue incorporation Vascularization

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