Proteolysis targeting chimera technology:a novel strategy for treating diseases of the central nervous system

作     者：Ke Ma Xiao-Xiao Han Xiao-Ming Yang Song-Lin Zhou Ke Ma;Xiao-Xiao Han;Xiao-Ming Yang;Song-Lin Zhou

作者机构：Key Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina College of Life ScienceNantong UniversityNantongJiangsu ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第10期

页      面：1944-1949页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China,No.81870975(to SLZ) the Nantong Science and Technology Innovation Program,China,No.JC2019028(to XMY) 

主　　题：Alzheimer’s disease disease treatment drug development Huntington’s disease proteolysis targeting chimera stroke targeted degradation 

摘      要：Neurological diseases such as stroke,Alzheimer’s disease,Parkinson’s disease,and Huntington’s disease are among the intractable diseases for which appropriate drugs and treatments are *** targeting chimera(PROTAC)technology is a novel strategy to solve this *** technology uses the ubiquitin-protease system to eliminate mutated,denatured,and harmful proteins in *** can be reused,and utilizes the protein destruction mechanism of the cells,thus making up for the deficiencies of traditional protein degradation *** can effectively target and degrade proteins,including proteins that are difficult to identify and ***,it has extremely important implications for drug development and the treatment of neurological *** present,the targeted degradation of mutant BTK,mHTT,Tau,EGFR,and other proteins using PROTAC technology is gaining *** is expected that corresponding treatment of nervous system diseases can be *** review first focuses on the recent developments in PROTAC technology in terms of protein degradation,drug production,and treatment of central nervous system diseases,and then discusses its *** review will provide a brief overview of the recent application of PROTAC technology in the treatment of central nervous system diseases.