Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation
作者机构：Guangxi Key Laboratory of Regenerative MedicineGuangxi Engineering Center in Biomedical Material for Tissue and Organ RegenerationCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development nd Application Co-Constructed by the Province and MinistryThe First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Pharmaceutical CollegeGuangxi Medical UniversityNanning 530021China CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第12期
页 面：13259-13266页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 100104[医学-病理学与病理生理学] 0836[工学-生物工程] 10[医学]
基 金：funded by the Beijing Natural Science Foundation(No.JQ20005) Guangxi Science and Technology Major Project(No.GuikeAA19254002)
主 题：drug delivery coordination-driven assembly nanomedicine anti-inflammation therapy
摘 要：Developing dedicated nanomedicines to improve delivery efficacy of anti-inflammatory drugs is still a formidable *** this study,we present an extremely simple yet efficient approach to obtain hybrid nanodrugs through metal-drug coordination-driven self-assembly for carrier-free drug *** resulting metallo-nanodrugs exhibit well-defined morphology and high drug encapsulation capability,allowing for the combination of magnetic resonance imaging and anti-inflammatory *** the case of osteoarthritis(OA),the metallo-nanodrugs remarkably alleviate synovial inflammation,preventing cartilage destruction and extracellular matrix *** addition,it led to significantly improved therapeutic efficacy compared with intra-articular administration of the same dose of free drugs in OA mouse *** work provides a very simple approach for the development of anti-inflammatory nanoformulations by exploiting coordination-driven self-assembly.
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