Application of stem cells in peripheral nerve regeneration
作者机构：Key Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-innovation Center of NeuroregenerationNantong UniversityNantongJiangsuChina Nuclear Medicine DepartmentJiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsuChina
出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)
年 卷 期：2020年第8卷第1期
页 面：407-416页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Major Project of Research and Development[grant numbers 2017YFA0104700,2016YFC1101603] the National Natural Science Foundation of China[grant numbers 31730031,31700926] Jiangsu Provincial Key Medical Center and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China[PAPD]
主 题：Peripheral nerve injury Tissue-engineered nerve grafts Seed cells Stem cells Peripheral nerve regeneration
摘 要：Traumatic peripheral nerve injury is a worldwide clinical issue with high *** severity of peripheral nerve injury can be classified as neurapraxia,axonotmesis or neurotmesis,according to Seddon’s classification,or five different degrees according to Sunderland’s *** with neurotmesis suffer from a complete transection of peripheral nerve stumps and are often in need of surgical repair of nerve *** applications of autologous nerve grafts as the golden standard for peripheral nerve transplantation meet some difficulties,including donor nerve sacrifice and nerve *** have been made to construct tissue-engineered nerve grafts as supplements or even substitutes for autologous nerve grafts to bridge peripheral nerve *** incorporation of stem cells as seed cells into the biomaterial-based scaffolds increases the effectiveness of tissue-engineered nerve grafts and largely boosts the regenerative *** stem cells,including embryonic stem cells,neural stem cells,bone marrow mesenchymal stem cells,adipose stem cells,skin-derived precursor stem cells and induced pluripotent stem cells,have been used in neural tissue *** the current review,recent trials of stem cell-based tissue-engineered nerve grafts have been summarized;potential concerns and perspectives of stem cell therapeutics have also been contemplated.
维普期刊数据库