Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

作     者：Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Yubo Wang;Tingli Yuan;Tianjie Lyu;Ling Zhang;Meng Wang;Zhiying He;Yongjun Wang;Zixiao Li

作者机构：Vascular NeurologyDepartment of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological DiseasesBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational MedicineShanghaiChina National Center for Healthcare Quality Management in Neurological DiseasesBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative MedicineShanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain ResearchBeijingChina Research Unit of Artificial Intelligence in Cerebrovascular DiseaseChinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological DiseasesBeijingChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第1期

页      面：67-81页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from the Major Program of National Key Research and Development Project,Nos.2020YFA0112600(to ZH) the National Natural Science Foundation of China,No.82171270(to ZL) Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People’s Republic of China,No.2020-0103-3-1(to ZL) the Natural Science Foundation of Beijing,No.Z200016(to ZL) Beijing Talents Project,No.2018000021223ZK03(to ZL) Beijing Municipal Committee of Science and Technology,No.Z201100005620010(to ZL) CAMS Innovation Fund for Medical Sciences,No.2019-I2M-5-029(to YW) Shanghai Engineering Research Center of Stem Cells Translational Medicine,No.20DZ2255100(to ZH) 

主　　题：cell therapy immune cell inflammatory ischemic stroke stem cell 

摘      要：Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.