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Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis

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Cancer Communications 2024年第7期44卷 718-738页

作者： Wei Mu Pengfei Gu Huating Li Jinjin Zhou Yulun Jian Weiping Jia Yang Ge School of Public Health Center for Single-cell OmicsShanghai Jiao Tong University School of MedicineShanghaiP.R.China shanghai Key Laboratory of Diabetes Mellitus Department of Endocrinology and MetabolismShanghai Diabetes InstituteShanghai Clinical Center for DiabetesShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiP.R.China

Background:Benzo[a]pyrene(B[a]P),a carcinogen pollutant produced by combustion processes,is present in the western diet with grilled *** exposure of B[a]P in hepatocellular carcinoma(HCC)cells promotes metastasis rather than primary proliferation,implying an unknown mechanism of B[a]P-induced *** that exosomes carry bioactive molecules to distant sites,we investigated whether and how exosomes mediate cancer-stroma communications for a toxicologically associated ***:Exosomes were isolated from B[a]P stimulated BEL7404 HCC cells(7404-100Bap Exo)at an environmental relevant dose(100 nmol/L).Lung preeducation animal model was prepared via injection of exosomes and *** inflammatory genes of educated lungs were evaluated using quantitative reverse transcription PCR *** LM3 cells transfected with firefly luciferase were next injected to monitor tumor burdens and organotropic *** of B[a]P-exposed exosomes were determined by ceRNA *** between circular RNA(circRNA)and microRNAs(miRNAs)were detected using RNA pull-down in target lung *** in situ hybridization and RNA immunoprecipitation assay was used to evaluate the“on-off”interaction of circRNA-miRNA *** further developed an adenoassociated virus inhalation model to examine mRNA expression specific in lung,thereby exploring the mRNA targets of B[a]P induced circRNA-miRNA ***:Lung fibroblasts exert activation phenotypes,including focal adhesion and motility were altered by 7404-100Bap *** the exosome-educated in vivo model,fibrosis factors and pro-inflammatory molecules of are up-regulated when injected with *** to non-exposed 7404 cells,circ_0011496 was up-regulated following B[a]P treatment and wasmainly packaged into 7404-100Bap *** circ_0011496 were delivered and competitively bound to miR-486-5p in recipient *** down-regulation of miR-486-5p converted fi

关键词： benzo(a)pyrene cancer associate fibroblast circular RNA exosome organotropic metastasis

Fabrication and electrical characteristics of flash-sintered SiO_(2)-doped ZnO-Bi_(2)O_(3)-MnO_(2) varistors

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Journal of Advanced Ceramics 2020年第6期9卷 683-692页

作者： Pai PENG Yujun DENG Jingpeng NIU Liyi SHI Yunzhu MEI sanming DU Juan LIU Dong XU Key Laboratory of green Fabrication and Surface technology of Advanced Metal Materials(Anhui University of technology) Ministry of EducationMa'anshan 243002China Key Laboratory of Etallurgical Emission Reduction&Resources Recycling(Anhui University of technology) Ministry of EducationMa'anshan 243002China research center of Nano Science and technology Shanghai UniversityShanghai 200444China National United engineering Laboratory for Advanced Bearing Tribology Henan University of Science and TechnologyLuoyang 471023China

The dense ZnO-Bi_(2)O_(3)-MnO_(2)(ZBMS)varistors for x=0,1,2,3 wt% were fabricated by flash sintering method under the low temperature of 850℃ within 2 *** sample temperature was estimated by a black body radiation model in the flash sintering *** crystalline phase assemblage,density,microstructure,and electrical characteristics of the flash-sintered ZBMS varistors with different SiO_(2)-doped content were *** to the XRD analysis,many secondary phases were detected due to the SiO_(2) ***,the average grain size decrease with increasing SiO_(2)-doped *** improved nonlinear characteristics were obtained in SiO_(2)-doped samples,which can be attributed to the ion migration and oxygen absorption induced by the doped SiO_(2).The flash-sintered ZBMS varistor ceramics for x=2 wt% exhibited excellent comprehensive electrical properties,with the nonlinear coefficient of 24.5,the threshold voltage and leakage current of 385 V·mm^(-1 )and 11.8μA,respectively.

关键词： flash sintering SiO_(2)additive ZBMS varistors electrical properties

A Breakthrough in Understanding the Rapid Antidepressant Effect of Ketamine Based on Structural Analysis

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Neuroscience Bulletin 2022年第2期38卷 229-231页

作者： Hongmei Liu Xiaohui Wu Jun Chen Yiru Fang Clinical research center Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China CAS center for Excellence in Brain Science and Intelligence technology Shanghai 200031China shanghai Key Laboratory of Psychotic disorders Shanghai 201108China

Major depressive disorder(MDD)is one of the most common and serious mental *** overall 12-month prevalence rate is〜6%,while the lifetime risk increases about twofold(15%-18%),which means almost one in five people will experience at least one depressive episode during their lifetime[1].MDD is characterized by sad emotion accompanied by anhedonia,lack of energy or appetite,sleep disturbance,and low *** severe cases,suicidal ideation/attemp^ehavior or self-injurious behavior may occur,which seriously affects patients'daily life and social *** 2010,MDD was listed as the second greatest disease burden in the world,and is expected to rank first by 2030[2].

关键词： function lifetime listed

The Relationship Between Neuroimmunity and Bipolar Disorder:Mechanism and Translational Application

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Neuroscience Bulletin 2019年第4期35卷 595-607页

作者： Zhiang Niu Lu Yang Xiaohui Wu Yuncheng Zhu Jun Chen Yiru Fang Clinical research center Division of Mood Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai 200030 China CAS center for Excellence in Brain Science and Intelligence technology Shanghai 200031 China shanghai Key Laboratory of Psychotic Disorders Shanghai 201108 China

Neuroimmune system may be involved in the pathological process of bipolar disorder(BD),but the essential association is not fully *** evidence has shown that BD involves the activation of immune cells and the release of inflammatory substances in the central nerve system(CNS).Meanwhile,neuroimmune responses also interact with other hypothesis of the etiology of BD that are widely recognized,such as neurotransmitter systems,neuroendocrine systems,neurotrophic factors,and oxidative ***,related genes and immune changes in peripheral blood vary with ***,neuroimmunity may play an important role in the pathogenesis of BD,and the inflammatory cytokines,especially interleukin-6 and tumor necrosis factor-alpha,have potential value for the clinical diagnosis and prognosis of BD,as well as predicting the therapeutic effects of ***-scale studies are needed to extend the evidence on neuroimmunity in BD,and to examine its clinical value for applications such as early prediction and treatment.

关键词： Neuroimmunity Inflammation Cytokines Bipolar disorder Translational application

Hypothalamic-Pituitary-End-Organ Axes:Hormone Function in Female Patients with Major Depressive Disorder

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Neuroscience Bulletin 2021年第8期37卷 1176-1187页

作者： Yuncheng Zhu Xiaohui Wu Rubai Zhou Oliver Sie Zhiang Niu Fang Wang Yiru Fang Division of Mood Disorders Shanghai Hongkou Mental Health CenterShanghai200083China Clinical research center Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai200030China shanghai Medical College Fudan UniversityShanghai200032China shanghai Yangpu Mental Health center Shanghai200093China CAS center for Excellence in Brain Science and Intelligence technology Shanghai200031China shanghai Key Laboratory of Psychotic Disorders Shanghai201108China

Classic hypothalamic-pituitary-end-organ feedback loops–the hypothalamic-pituitary-adrenal axis(HPAA),hypothalamic-pituitary-thyroidal axis(HPTA),and hypothalamic-pituitary-gonadal axis(HPGA)–are associated with the neuroendocrine and immune systems in major depressive disorder(MDD).Female patients with MDD present with evident neuroendocrine and immunological ***,thyroid hormone,and reproductive steroid levels fluctuate with menstrual cycles,which might lead to glucocorticoid receptor resistance,impairment of triiodothyronine conversion,and sex hormone secretion *** this review,we summarize the independent and interactive functions of these three axes in female MDD *** similar molecular structure of steroids implies an interrelationship between the hypothalamic-pituitary-end-organ axes and the competitive inhibitory effects at the receptor level,especially when considering the HPAA and HPGA.

关键词： Major depressive disorder Neurosecretory systems Sex steroid hormones

Major Depressive Disorder: Advances in Neuroscience research and Translational Applications

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Neuroscience Bulletin 2021年第6期37卷 863-880页

作者： Zezhi Li Meihua Ruan Jun Chen Yiru Fang Clinical research center and Division of Mood Disorders of shanghai Mental Health center Shanghai Jiao Tong University School of MedicineShanghai 200030China Department of Neurology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China shanghai Institute of Nutrition and Health Shanghai Information Center for Life SciencesChinese Academy of ScienceShanghai 200031China center for Excellence in Brain Science and Intelligence technology Chinese Academy of ScienceShanghai 200031China shanghai Key Laboratory of Psychotic Disorders Shanghai 201108China

Major depressive disorder(MDD),also referred to as depression,is one of the most common psychiatric disorders with a high economic *** etiology of depression is still not clear,but it is generally believed that MDD is a multifactorial disease caused by the interaction of social,psychological,and biological ***,there is no exact pathological theory that can independently explain its pathogenesis,involving genetics,neurobiology,and *** present,there are many treatment measures for patients with depression,including drug therapy,psychotherapy,and neuromodulation *** recent years,great progress has been made in the development of new antidepressants,some of which have been applied in the *** article mainly reviews the research progress,pathogenesis,and treatment of MDD.

关键词： Major depressive disorder Pathogenesis Treatment Progress

Disturbances of affective cognition in mood disorders

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Science China(Life Sciences) 2021年第6期64卷 938-941页

作者： Jun Chen Zuowei Wang Zezhi Li Daihui Peng Yiru Fang Clinical research center&Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Guangdong-Hong Kong-Macao Greater Bay Area center for Brain Science and Brain-Inspired Intelligence Guangzhou 510515China Hongkou District Mental Health center of shanghai Shanghai 200083China Ren Ji Hospital Shanghai Jiao Tong University School of MedicineShanghai 200127China CAS center for Excellence in Brain Science and Intelligence technology Shanghai 200031China shanghai Key Laboratory of Psychotic Disorders Shanghai 201108China

Mood disorders,also known as affective disorders,result in a consistent disturbance in *** are two major subtypes of mood disorders,i.e.,major depressive disorder(MDD)and bipolar disorder(BD).Mood disorders affect hundreds of millions of people and are the most common mental *** to China’s national survey in2009(Phillips et al.,2009),the weighted 12-month prevalence of mental disorders was 17.5%and 9.3%,*** disorders were among the highest prevalence rate disorders related to disease’s increased burdens.

关键词： disorders prevalence al.

Targeted trace ingredients coupled with chemometric analysis for consistency evaluation of Panax notoginseng saponins injectable formulations

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中国天然药物:英文版 2023年第8期21卷 631-640页

作者： ZHANG Jingxian ZHANG Zijia WANG Zhaojun ZHANG Tengqian ZHOU Yang CHEN Ming HUANG Zhanwen HE Qingqing LONG Huali HOU Jinjun WU Wanying GUO Dean National engineering research center of TCM Standardization technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine Shanghai Institute for Food and Drug ControlShanghai 201203China Guangxi Key Laboratory of Comprehensive Utilization technology of Pseudo-Ginseng Guangxi Zhongheng Innovative Pharmaceutical Research Co.Ltd.Guangxi 530032China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China

Evaluating the consistency of herb injectable formulations could improve their product quality and clinical safety,particularly concerning the composition and content levels of trace *** notoginseng Saponins Injection(PNSI),widely used in China for treating acute cardiovascular diseases,contains low-abundance(10%-25%)and trace saponins in addition to its five main constituents(notoginsenoside R1,ginsenoside Rg1,ginsenoside Re,ginsenoside Rb1,and ginsenoside Rd).This study aimed to establish a robust analytical method and assess the variability in trace saponin levels within PNSI from different vendors and formulation *** achieve this,a liquid chromatography-triple quadrupole mass spectrometry(LC-MS/MS)method employing multiple ions monitoring(MIM)was developed.A“post-column valve switching”strategy was implemented to eliminate highly abundant peaks(NR_(1),Rg_(1),and Re)at 26 min.A total of 51 saponins in PNSI were quantified or relatively quantified using 18 saponin standards,with digoxin as the internal *** study evaluated 119 batches of PNSI from seven vendors,revealing significant variability in trace saponin levels among different vendors and formulation *** findings highlight the importance of consistent content in low-abundance and trace saponins to ensure product control and clinical *** of these ingredients is crucial for maintaining the quality and effectiveness of PNSI in treating acute cardiovascular diseases.

关键词： Consistency evaluation Panax notoginseng saponins PCA analysis Xueshuantong Xuesaitong

Exploring the interconnectivity of biomimetic hierarchical porous Mg scaffolds for bone tissue engineering:Effects of pore size distribution on mechanical properties,degradation behavior and cell migration ability

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Journal of Magnesium and Alloys 2021年第6期9卷 1954-1966页

作者： Gaozhi Jia Hua Huang Jialin Niu Chenxin Chen Jian Weng Fei Yu Deli Wang Bin Kang Tianbing Wang Guangyin Yuan Hui Zeng Department of Bone&Joint Surgery Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen 518036China National engineering research center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai 200240China Beijing Key Laboratory of Civil Aircraft Structures and Composite Materials Beijing Aircraft Technology Research Institute of COMACBeijing 102211China National&Local Joint engineering research center of Orthopaedic Biomaterials Peking University Shenzhen HospitalShenzhen 518036China Department of Orthopaedics Peking University People's HospitalBeijing 100044China

Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and ***,efforts and understanding of the interconnectivity of porous Mg is limited due to the diverse architectures of pore struts and pore size distribution of Mg scaffold *** this work,biomimetic hierarchical porous Mg scaffolds with tailored interconnectivity as well as pore size distribution were prepared by template replication of infiltration *** scaffold with better interconnectivity showed lower mechanical *** interconnected pores would enhance the interconnectivity of the whole scaffold and reduce the change of ion concentration,pH value and osmolality of the degradation microenvironment due to the lower specific surface ***,the degradation rates of five tested Mg scaffolds were no different because of the same geometry of strut *** cell culture and evaluation of cell density at both sides of four typical Mg scaffolds indicated that cell migration through hierarchical porous Mg scaffolds could be enhanced by not only bigger interconnected pore size but also larger main pore *** summary,design of interconnectivity in terms of pore size distribution could regulate mechanical strength,microenvironment in cell culture condition and cell migration potential,and beyond that it shows great potential for personalized therapy which could facilitate the regeneration process.

关键词： Bone tissue engineering Porous Mg scaffold Interconnectivity Pore size distribution Cell migration