Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications
作者机构：Clinical Research Center and Division of Mood Disorders of Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Department of NeurologyRen Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Shanghai Institute of Nutrition and HealthShanghai Information Center for Life SciencesChinese Academy of ScienceShanghai 200031China Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of ScienceShanghai 200031China Shanghai Key Laboratory of Psychotic DisordersShanghai 201108China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2021年第37卷第6期
页 面：863-880页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：This review was supported by the National Basic Research Development Program of China(2016YFC1307100) the National Natural Science Foundation of China(81930033 and 81771465 81401127) Shanghai Key Project of Science&Technology(2018SHZDZX05) Shanghai Jiao Tong University Medical Engineering Foundation(YG2016MS48) Shanghai Jiao Tong University School of Medicine(19XJ11006) the Sanming Project of Medicine in Shenzhen Municipality(SZSM201612006) the National Key Technologies R&D Program of China(2012BAI01B04) the Innovative Research Team of High-level Local Universities in Shanghai.
主 题：Major depressive disorder Pathogenesis Treatment Progress
摘 要：Major depressive disorder(MDD),also referred to as depression,is one of the most common psychiatric disorders with a high economic burden.The etiology of depression is still not clear,but it is generally believed that MDD is a multifactorial disease caused by the interaction of social,psychological,and biological aspects.Therefore,there is no exact pathological theory that can independently explain its pathogenesis,involving genetics,neurobiology,and neuroimaging.At present,there are many treatment measures for patients with depression,including drug therapy,psychotherapy,and neuromodulation technology.In recent years,great progress has been made in the development of new antidepressants,some of which have been applied in the clinic.This article mainly reviews the research progress,pathogenesis,and treatment of MDD.
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