The Relationship Between Neuroimmunity and Bipolar Disorder:Mechanism and Translational Application

作     者：Zhiang Niu Lu Yang Xiaohui Wu Yuncheng Zhu Jun Chen Yiru Fang 

作者机构：Clinical Research Center Division of Mood Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai 200030 China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031 China Shanghai Key Laboratory of Psychotic Disorders Shanghai 201108 China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2019年第35卷第4期

页      面：595-607页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Basic Research Development Program of China (2016YFC1307100) the Shanghai Mental Health Centre Clinical Research Center Special Project for Big Data Analysis (CRC2018DSJ01-1) the Sanming Project of Medicine in Shenzhen City (SZSM201612006) the National Natural Science Foundation of China (91232719 and 81771465) the National Key Clinical Disciplines at Shanghai Mental Health Centre (OMA-MH, 2011-873) 

主　　题：Neuroimmunity Inflammation Cytokines Bipolar disorder Translational application 

摘      要：Neuroimmune system may be involved in the pathological process of bipolar disorder(BD),but the essential association is not fully understood.Accumulating evidence has shown that BD involves the activation of immune cells and the release of inflammatory substances in the central nerve system(CNS).Meanwhile,neuroimmune responses also interact with other hypothesis of the etiology of BD that are widely recognized,such as neurotransmitter systems,neuroendocrine systems,neurotrophic factors,and oxidative stress.Simultaneously,related genes and immune changes in peripheral blood vary with it.Overall,neuroimmunity may play an important role in the pathogenesis of BD,and the inflammatory cytokines,especially interleukin-6 and tumor necrosis factor-alpha,have potential value for the clinical diagnosis and prognosis of BD,as well as predicting the therapeutic effects of drugs.Large-scale studies are needed to extend the evidence on neuroimmunity in BD,and to examine its clinical value for applications such as early prediction and treatment.