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Surface morphology and cell viability of samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide/polycaprolactone targeting wound dressing

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Journal of Rare Earths 2024年第3期42卷 555-561,I0005页

作者： Muteb H.Alshammari Ahmed Onayzan Alshammari Mohamed Tharwat Elabbasy Rafat Zreiq Faris Mohammed Albati M.A.El-Morsy A.A.Menazea Department of Health Informatics College of Public Health and Health InformaticsUniversity of Ha'ilHa'ilSaudi Arabia Department of Surgery College of MedicineUniversity of Ha'ilHa'ilSaudi Arabia Department of Public Health College of Public Health and HealthInformaticsHalUniversityHa'il2440Saudi Arabi Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Applied Science Research Center Applied Science Private UniversityAmman541350Jordan College of Shariah and Law Ha'il UniversityHa'il2440Saudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamittaNew Damietta34517.Egyp Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt

Combinations of metal and lanthanide oxides have been done through casted films for potential medical applications. In this regard, samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide(GO)/polycaprolactone(PCL) based films nano-composites(NCs) were fabricated, pointing their utilization as a biological scaffold for wound dressing purposes. Also, samarium(Ⅲ) oxide and chromium(Ⅲ) oxide have been merged as promising optical constituents due to their unique optical behavior. The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD), Raman, and field emission scanning electron microscopy(FESEM). The Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL NC exhibits a surface with a lower roughness degree owing to the presence of GO. Cr_(2)O_(3)shows size reduction upon GO insertion to reach 1.2 μm as the average grain size, whilst Sm_(2)O_(3)records an average grain size of less than 1 μm. As well, the polymeric nano-compositions exhibit variation in contact angle values that hit 29.76°± 3.52°for Sm_(2)O_(3)/PCL, and 48.62°± 1.37°for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL as the second lowest contact angle. The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCL, to 2.65 eV for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL. Regarding biological responses, the cell exposed to 2.5 μg/m L of Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL shows cell viability of 119.31%, while 5 μg/m L hits 99.6%. Additionally, the resulting cell attachment micrographs show layers of fibroblast tissue, besides the proliferation and growth of cultivated cells. Thus, the Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.

关键词： wound healing wound dressing Polycaprolactone Sm_(2)O_(3) Cr_(2)O_(3) Rare earths

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Antimicrobial-free knitted fabric as wound dressing and the mechanism of promoting infected wound healing

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Science China(Technological Sciences) 2023年第7期66卷 2147-2154页

作者： ZHANG Huan WAN HuaKun HU XiuYuan ZHAO QingHua LU JianGuo WANG Dong LU ZhenTan Key Laboratory of Textile Fiber and Products(Wuhan Textile University)Ministry of Education Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials&ApplicationWuhan Textile UniversityWuhan 430200China Zhende Medical Co. Ltd.Shaoxing 312000China

Fibrous biomaterials are widely used in the design and fabrication of antibacterial wound *** strategies are used to make anti-infective dressings:antibacterial and probiotic therapies,which have potential biotoxicity and other ***,we report a new strategy for fabricating wound dressings to combat ***(4-methyl-1-pentene)(PMP) fabric can remove bacteria from infectious wounds through dressing changes based on its efficient bacterial *** maximum adhered count of *** and *** on the PMP fabric was 1.63 × 106CFU/cm~2 and 4.77 × 105CFU/cm~2,*** addition,the PMP fabric could inhibit the twitching motility of bacteria,which is beneficial for inhibiting *** ability of the PMP fabric to accelerate wound healing was demonstrated in vivo in a rat wound *** treatment with the PMP fabric dressing,pathogenic bacteria in the wound were removed through dressing change;therefore,the wound exhibited better healing speed than when the commercial dressing was *** low bacterial concentration effectively stimulated the expression of growth factors and suppressed wound inflammation,thereby accelerating wound *** fabric has three advantages:(1) it has been approved for use in clinical treatment by the Food and Drug Administration;(2) no antibacterial agent or probiotics were used;(3) the fabric could be manufactured through an industrial production *** results indicate that the new strategy can be used in the design of new-generation wound dressings for antibacterial applications.

关键词： anti-infection bacterial adhesion healing mechanism knitted fabric wound dressing

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Quaternized chitosan/Pluronic F127 thermosensitive hydrogel with high antibacterial properties for wound dressing

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Progress in Natural Science:Materials International 2023年第5期33卷 581-592页

作者： Kaiting Cheng Yiming Fang Liang Bai Feng Gui Junchi Ma Huimin Gao Yadong Zhao Xingtao Xu Marine Science and Technology College Zhejiang Ocean University Anhui Snow Dragon Fibre Technology CO. LTD. School of Food and Pharmacy Zhejiang Ocean University

In everyday life, traditional dressings such as band-aid and gauze are used for dealing with small ***, these dressings have shortcomings such as pain caused by tearing, inapplicability to joints, single functionality, and adverse reactions. Therefore, there is a great need for an inexpensive, comfortable, and multifunctional wound dressing. In this study, quaternized chitosan(QCS) with a high degree of substitution(107.84%) was successfully prepared and characterized using ultraviolet–visible(UV–vis) spectroscopy, Fourier transform infrared(FT-IR) spectroscopy, X-ray diffraction(XRD), and proton nuclear magnetic resonance(1H NMR). A series of QCS/F127 thermosensitive hydrogels were prepared by physical cross-linking and used as potential wound dressings. Then the temperature sensitivity, hemostatic ability, antibacterial activity, and sustained drug release effect of the hydrogels were investigated to evaluate their multifunctionality as wound dressings. Finally, the effect of QCS concentration on hydrogel properties was explored. The results show that the composite hydrogels have significant hemostatic, antibacterial, and sustained drug release abilities, and they can be rapidly transformed into a gel state and adhere to skin upon reaching body temperature. In addition, the properties of the hydrogels can be adjusted by varying the concentration of QCS, which allows for the preparation of wound dressings that are responsive to needs. Therefore, multifunctional QCS/F127 hydrogels with temperatureresponse characteristics are of great clinical research value as wound dressings.

关键词： Thermosensitive hydrogel wound dressing Antibacterial activity Hemostasis Drug delivery

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Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing

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Bioactive Materials 2022年第2期7卷 341-354页

作者： Yutong Yang Yongping Liang Jueying Chen Xianglong Duan Baolin Guo Second Department of General Surgery Shaanxi Provincial People’s HospitalXi’an710068China Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materialsand Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of StomatologyXi’an Jiaotong UniversityXi’an710049China Second Department of General Surgery Third Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710068China

With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds,the development of new antibacterial and accelerated wound healing dressings has become a serious *** order to solve this problem,we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan(CSG-PEG),methacrylamide dopamine(DMA)and zinc ion for disinfection of drug-resistant bacteria and promoting wound *** mechanical properties,rheological properties and morphology of hydrogels were characterized,and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility *** hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation *** addition,it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus(MRSA).In the full-thickness skin defect model infected with MRSA,the wound closure ratio,thickness of granulation tissue,number of collagen deposition,regeneration of blood vessels and hair follicles were *** inflammation-related cytokines(CD68)and angiogenesis-related cytokines(CD31)expressed during skin regeneration were *** results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™Film,revealing that they have become promising alternative in the healing of infected wounds.

关键词： Chitosan wound dressing Antibacterial wound healing Hemostat Infected skin wound

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A facile and general method for synthesis of antibiotic-free protein-based hydrogel:wound dressing for the eradication of drug-resistant bacteria and biofilms

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Bioactive Materials 2022年第12期7卷 446-458页

作者： Jiang Ouyang Qingyue Bu Na Tao Mingkai Chen Haijun Liu Jun Zhou Jinggong Liu Bo Deng Na Kong Xingcai Zhang Tianfeng Chen Yihai Cao Wei Tao The First Affiliated Hospital Department of ChemistryJinan UniversityGuangzhou510632China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138USA College of Chemistry and Chemical Engineering Central South UniversityChangshaHunan410083China The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangdong Provincial Academy of Chinese Medical SciencesGuangzhou510006China Department of Microbiology Tumor and Cell BiologyKarolinska InstituteStockholm17177Sweden

Antibacterial protein hydrogels are receiving increasing attention in the aspect of bacteria-infected-wound healing. However, bacterial drug resistance and biofilm infections lead to hard healing of wounds, thus the construction of biological agents that can overcome these issues is essential. Here, a simple and universal method to construct antibiotic-free protein hydrogel with excellent biocompatibility and superior antibacterial activity against drug-resistant bacteria and biofilms was developed. The green industrial microbicide tetrakis (hydroxymethyl) phosphonium sulfate (THPS) as cross-linking agent can be quickly cross-linked with model protein bovine serum albumin (BSA) to form antibacterial hydrogel through simple mixing without any other initiators, subsequently promoting drug-resistance bacteria-infected wound healing. This simple gelatinization strategy allows at least ten different proteins to form hydrogels (e.g. BSA, human serum albumin (HSA), egg albumin, chymotrypsin, trypsin, lysozyme, transferrin, myohemoglobin, hemoglobin, and phycocyanin) under the same conditions, showing prominent universality. Furthermore, drug-resistance bacteria and biofilm could be efficiently destroyed by the representative BSA hydrogel (B-Hydrogel) with antibacterial activity, overcoming biofilm-induced bacterial resistance. The in vivo study demonstrated that the B-Hydrogel as wound dressing can promote reepithelization to accelerate the healing of methicillin-resistant staphylococcus aureus (MRSA)-infected skin wounds without inducing significant side-effect. This readily accessible antibiotic-free protein-based hydrogel not only opens an avenue to provide a facile, feasible and general gelation strategy, but also exhibits promising application in hospital and community MRSA disinfection and treatment.

关键词： THPS Protein hydrogel Bacterial resistance Anti-Biofilm wound dressing

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Efficient scarless skin regeneration enabled by loading micronized amnion in a bioinspired adhesive wound dressing

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Aggregate 2023年第5期4卷 96-111页

作者： Huicong Zhang Mingyu Song Changhong Hu Zhiyi Zhang Shuqi Zhang Yan Zhang Yingming Yang Puxu Zhou Liwen Zheng Lan Li Mengjie Mao Yu Shrike Zhang Ping Ji Ximu Zhang Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital of Chongqing Medical University ChongqingChina Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Department of Preventive Dentistry State Key Laboratory of Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduChina School of Stomatology Zunyi Medical UniversityZunyiChina

Complete skin reconstruction is a hierarchical,physiological assembly process involving healing of the epidermis,dermis,vasculature,nerves,and cutaneous *** date,few works have reported complete skin regeneration,particularly lacking vascular structures and hair follicles after full skin *** this study,a hydrogel derived from the skin secretion of Andrias davidianus(SSAD)that features adhesiveness was used as a bioactive scaffold to load micronized amnion(MA).The SSAD hydrogel was found to promote the migration and proliferation of amnion stem cells and human keratinocytes,as well as inhibit their apoptosis in *** a rat full-skin defect model,the regeneration of skin appendages was observed at the wound area,achieving scarless *** analyses further validated that SSAD could positively regulate cell migration,proliferation,and *** functions might be attributed to the abundant growth factors present in the *** by the delivery of MA,SSAD loaded with the MA could achieve a significantly better skin regeneration effect than SSAD or MA used alone,providing a simple yet highly effective means to obtain complete,scarless skin regeneration,suggesting favorable potential for clinical translation.

关键词： amnion Andrias davidianus cell delivery cutaneous appendages scarless wound dressing

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A nanoconcrete welding strategy for constructing high-performance wound dressing

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Bioactive Materials 2022年第8期7卷 31-41页

作者： Yingshuai Wang Yanxia Zhu Penghe Zhao Bin Wei Mingjian Fan Danyang Chen Zhaokui Jin Qianjun He School of Life Science and Technology Weifang Medical UniversityWeifangShandongChina Central Laboratory Longgang District People’s Hospital of Shenzhen&the Third Affiliated Hospital(Provisional)of the Chinese University of Hong KongShenzhenGuangdongChina School of Biomedical Engineering Health Science CenterShenzhen UniversityNo.1066 Xueyuan RoadShenzhen518060GuangdongChina Department of Quantum and Energy Materials International Iberian Nanotechnology Laboratory(INL)Braga4715-330Portugal Center of Hydrogen Science Shanghai Jiao Tong UniversityShanghai200240China

Engineering biomaterials to meet specific biomedical applications raises high requirements of mechanical performances,and simultaneous strengthening and toughening of polymer are frequently necessary but very challenging in many *** this work,we propose a new concept of nanoconcrete welding polymer chains,where mesoporous CaCO3(mCaCO_(3))nanoconcretes which are composed of amorphous and nanocrystalline phases are developed to powerfully weld polymer chains through siphoning-induced occlusion,hydration-driven crystallization and dehydration-driven compression of *** mCaCO_(3) nanoconcrete welding technology is verified to be able to remarkably augment strength,toughness and anti-fatigue performances of a model polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based porous ***,we have revealed polymer-occluded nanocrystal structure and welding-derived microstress which is much stronger than interfacial Van der Waals force,thus efficiently preventing the generation of microcracks and repairing initial microcracks by microcracks-induced hydration,crystallization and polymer welding of mCaCO_(3) *** porous membrane is used as wound dressing,exhibiting a special nanoplates-constructed surface topography as well as a porous structure with plentiful oriented,aligned and opened pore channels,improved hydrophilicity,water vapor permeability,anti-bacterial and cell adherence,in support of wound healing and skin structural/functional *** proposed nanoconcrete-welding-polymer strategy breaks a new pathway for improving the mechanical performances of polymers.

关键词： Tissue engineering Mechanical performances Calcium carbonate Mesoporous materials Organic/inorganic nanocomposite wound dressing

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Antibacterial biomaterials for skin wound dressing

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Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 353-384页

作者： Yuqing Liang Yongping Liang Hualei Zhang Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human *** bacterial contamination could significantly menace the wound healing *** the sophisticated wound healing process,novel strategies for skin tissue engineering are focused on the integration of bioactive ingredients,antibacterial agents included,into biomaterials with different morphologies to improve cell behaviors and promote wound ***,a comprehensive review on antibacterial wound dressing to enhance wound healing has not been *** this review,various antibacterial biomaterials as wound dressings will be *** kinds of antibacterial agents,including antibiotics,nanoparticles(metal and metallic oxides,lightinduced antibacterial agents),cationic organic agents,and others,and their recent advances are *** selection and fabrication of biomaterials with different structures and forms,including films,hydrogel,electrospun nanofibers,sponge,foam and three-dimension(3D)printed scaffold for skin regeneration,are elaborated *** challenges and the future perspectives are presented in thismultidisciplinary *** envision that this review will provide a general insight to the elegant design and further refinement of wound dressing.

关键词： Antibacterial activity wound healing wound dressing Skin tissue engineering Biomaterials

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Novel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressing

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Journal of Materials Science & Technology 2021年第30期89卷 225-232页

作者： Wencheng Liang Mingli Jiang Junyong Zhang Xiaoming Dou Yan Zhou Yun Jiang Li Zhao Meidong Lang Center of Photonics&Bio-Medical Diagnosis School of ScienceEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering School of BiotechnologyEast China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering New World Institute of BiotechnologyEast China University of Science and TechnologyShanghai 200237China The Library of Zhejiang University of Technology Zhejiang University of TechnologyHangzhou 310023China

In this work,novel antibacterial cellulose diacetate/poly(ethylenimine)/hyaluronic acid(CDA/PEI/HA)composite three-dimension(3D)scaffolds were prepared through electrospinning and ***,CDA/PEI 2D composite nanofiber membranes were prepared by electrospinning,and then the CDA/PEI/HA 3D composite scaffolds were fabricated by post-processing and freeze-drying of CDA/PEI *** particular,HA was added to improve the biocompatibility of composite *** with CDA/PEI scaffolds,CDA/PEI/HA composite scaffolds showed higher water absorbing rate,higher water retention rate and higher mechanical ***,CDA/PEI/HA composite scaffolds with abundant positive charge were benefit for improving antibacterial ***/PEI/HA scaffolds with biology function of HA were benefit for improving hemocompatibility and cell proliferation of CDA/PEI *** summary,antibacterial CDA/PEI/HA scaffolds could protect wound from bacterial infection,improve cellular behavior and accelerate wound ***,CDA/PEI/HA scaffolds could be potential application for wound dressing.

关键词： Cellulose diacetate Electrospinning 3D scaffold wound dressing

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Molecular design, synthesis strategies and recent advances of hydrogels for wound dressing applications

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Chinese Journal of Chemical Engineering 2021年第2期34卷 308-320页

作者： Dan Zeng Shihong Shen Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China

With the changes in the modern disease spectrum,pressure ulcers,diabetic feet,and vascular-derived diseases caused refractory wounds is increasing *** development of wound dressings has partly improved the effect of wound ***,traditional wound dressings can only cover the wound and block bacteria,but are generally powerless to recurrent wound infection and tissue *** is an urgent need to develop a new type of wound dressing with comprehensive performance to achieve multiple effects such as protecting the wound site from the external environment,absorbing wound exudate,anti-inflammatory,antibacterial,and accelerating wound healing *** wound dressings have the aforementioned characteristics,and can keep the wound in a moist environment because of the high water content,which is an ideal choice for wound *** review introduces the wound healing process and the development and performance advantages of hydrogel wound *** choice of different preparation materials gives the particularities of different hydrogel wound *** also systematically explains the main physical and chemical crosslinking methods for hydrogel ***,in-depth discussion of four typical hydrogel wound dressings including double network hydrogels,nanocomposite hydrogels,drug-loaded hydrogels and smart hydrogels fully demonstrates the feasibility of developing hydrogels as wound dressing products and their future development trends.

关键词： Hydrogels wound dressing Molecular design Crosslinked networks Biomedical applications

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