A nanoconcrete welding strategy for constructing high-performance wound dressing
作者机构：School of Life Science and TechnologyWeifang Medical UniversityWeifangShandongChina Central LaboratoryLonggang District People’s Hospital of Shenzhen&the Third Affiliated Hospital(Provisional)of the Chinese University of Hong KongShenzhenGuangdongChina School of Biomedical EngineeringHealth Science CenterShenzhen UniversityNo.1066 Xueyuan RoadShenzhen518060GuangdongChina Department of Quantum and Energy MaterialsInternational Iberian Nanotechnology Laboratory(INL)Braga4715-330Portugal Center of Hydrogen ScienceShanghai Jiao Tong UniversityShanghai200240China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第8期
页 面：31-41页
核心收录：
基 金：supported by the National Natural Science Foundation of China(51872188) Shenzhen Basic Research Program(SGDX20201103093600004) Special Funds for the Development of Strategic Emerging Industries in Shenzhen(20180309154519685) SZU Top Ranking Project(860-00000210) the PhD Start-up Fund of Natural Science Foundation of Guangdong Province(2018A030310573,2021A1515011155) China Postdoctoral Science Foundation(2018M643171) Center of Hydrogen Science,Shanghai Jiao Tong University,China
主 题：Tissue engineering Mechanical performances Calcium carbonate Mesoporous materials Organic/inorganic nanocomposite Wound dressing
摘 要：Engineering biomaterials to meet specific biomedical applications raises high requirements of mechanical performances,and simultaneous strengthening and toughening of polymer are frequently necessary but very challenging in many *** this work,we propose a new concept of nanoconcrete welding polymer chains,where mesoporous CaCO3(mCaCO_(3))nanoconcretes which are composed of amorphous and nanocrystalline phases are developed to powerfully weld polymer chains through siphoning-induced occlusion,hydration-driven crystallization and dehydration-driven compression of *** mCaCO_(3) nanoconcrete welding technology is verified to be able to remarkably augment strength,toughness and anti-fatigue performances of a model polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based porous ***,we have revealed polymer-occluded nanocrystal structure and welding-derived microstress which is much stronger than interfacial Van der Waals force,thus efficiently preventing the generation of microcracks and repairing initial microcracks by microcracks-induced hydration,crystallization and polymer welding of mCaCO_(3) *** porous membrane is used as wound dressing,exhibiting a special nanoplates-constructed surface topography as well as a porous structure with plentiful oriented,aligned and opened pore channels,improved hydrophilicity,water vapor permeability,anti-bacterial and cell adherence,in support of wound healing and skin structural/functional *** proposed nanoconcrete-welding-polymer strategy breaks a new pathway for improving the mechanical performances of polymers.
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