Surface morphology and cell viability of samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide/polycaprolactone targeting wound dressing

作     者：Muteb H.Alshammari Ahmed Onayzan Alshammari Mohamed Tharwat Elabbasy Rafat Zreiq Faris Mohammed Albati M.A.El-Morsy A.A.Menazea Muteb H.Alshammari;Ahmed Onayzan Alshammari;Mohamed Tharwat Elabbasy;Rafat Zreiq;Faris Mohammed Albati;M.A.El-Morsy;A.A.Menazea

作者机构：Department of Health InformaticsCollege of Public Health and Health InformaticsUniversity of Ha'ilHa'ilSaudi Arabia Department of SurgeryCollege of MedicineUniversity of Ha'ilHa'ilSaudi Arabia Department of Public HealthCollege of Public Health and HealthInformaticsHalUniversityHa'il2440Saudi Arabi Food Control DepartmentFaculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Applied Science Research CenterApplied Science Private UniversityAmman541350Jordan College of Shariah and LawHa'il UniversityHa'il2440Saudi Arabia College of Science and Humanities in Al-KharjPhysics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics DepartmentFaculty of ScienceUniversity of DamittaNew Damietta34517.Egyp Spectroscopy DepartmentPhysics Research InstituteNational Research CentreDokki12622GizaEgypt 

出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)

年 卷 期：2024年第42卷第3期

页      面：555-561,I0005页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：funded by the Scientific Research Deanship at University of Ha'il Saudi Arabia through project number RG-21169 

主　　题：Wound healing Wound dressing Polycaprolactone Sm_(2)O_(3) Cr_(2)O_(3) Rare earths 

摘      要：Combinations of metal and lanthanide oxides have been done through casted films for potential medical applications. In this regard, samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide(GO)/polycaprolactone(PCL) based films nano-composites(NCs) were fabricated, pointing their utilization as a biological scaffold for wound dressing purposes. Also, samarium(Ⅲ) oxide and chromium(Ⅲ) oxide have been merged as promising optical constituents due to their unique optical behavior. The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD), Raman, and field emission scanning electron microscopy(FESEM). The Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL NC exhibits a surface with a lower roughness degree owing to the presence of GO. Cr_(2)O_(3)shows size reduction upon GO insertion to reach 1.2 μm as the average grain size, whilst Sm_(2)O_(3)records an average grain size of less than 1 μm. As well, the polymeric nano-compositions exhibit variation in contact angle values that hit 29.76°± 3.52°for Sm_(2)O_(3)/PCL, and 48.62°± 1.37°for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL as the second lowest contact angle. The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCL, to 2.65 eV for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL. Regarding biological responses, the cell exposed to 2.5 μg/m L of Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL shows cell viability of 119.31%, while 5 μg/m L hits 99.6%. Additionally, the resulting cell attachment micrographs show layers of fibroblast tissue, besides the proliferation and growth of cultivated cells. Thus, the Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.