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Neuroscience Bulletin 2013年第3期29卷 381-389页

作者： Michela Balconi Laboratory of Cognitive Psychology Department of Psychology Catholic University of Sacred Heart

The ability to recall and recognize facts we experienced in the past is based on a complex mechanism in which several cerebral regions are implicated. Neuroimaging and lesion studies agree in identifying the frontal lobe as a crucial structure for memory processes, and in particular for working memory and episodic memory and their relationships. Furthermore, with the introduction of transcranial magnetic stimulation （TMS） a new way was proposed to investigate the relationships between brain correlates, memory functions and behavior. The aim of this review is to present the main findings that have emerged from experiments which used the TMS technique for memory analysis. They mainly focused on the role of the dorsolateral prefrontal cortex in memory process. Furthermore, we present state-of-the-art evidence supporting a possible use of TMS in the clinic. Specifically we focus on the treatment of memory deficits in depression and anxiety disorders.

关键词： transcranial magnetic stimulation dorsolateral prefrontal cortex memory working memory anxiety depression

Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women

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Neural Regeneration Research 2013年第4期8卷 346-356页

作者： Yang-Kun Chen Wei-Min Xiao Defeng Wang Lin Shi Winnie CW Chu Vincent CT Mok Ka Sing Wong Gabor S Ungvari Wai Kwong Tang Department of Neurology Dongguan People's Hospital Department of Diagnostic Radiology and Organ Imaging the Chinese University of Hong Kong Department of Medicine and Therapeutics the Chinese University of Hong Kong Graylands Hospital School of Psychiatry & Clinical NeurosciencesUniversity of Western AustraliaPerth 6005Australia Department of Psychiatry the Chinese University of Hong Kong

This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke. Thirty elderly female patients with non-aphasic ischemic stroke aged -〉 60 years and 30 age-matched non-aphasic male patients with ischemic stroke were recruited. Automatic magnetic resonance imaging segmentation was used to assess the volume of the whole prefrontal cortex, along with its subdivisions： anterior cingulate cortex, orbitofrontal cortex and dorsolateral prefrontal cortex. The Semantic Verbal Fluency Test was administered at 3 and 15 months poststroke. At 3 months poststroke, left dorsolateral prefrontal cortex volume was significantly correlated with Verbal Fluency Test score in female patients only （partial coefficient = 0.453, P = 0.045）, after controlling for age, education, diabetes, neurological deficit, white matter lesions volume, as well as the location and volume of infarcts. At 15 months poststroke, there remained a significant association between the left dorsolateral prefrontal cortex volume and Verbal Fluency Test （partial coefficient = 0.661, P = 0.001） and between the left prefrontal cortex volume and Verbal Fluency Test （partial coefficient = 0.573, P = 0.004） in female patients after the same adjustments. These findings indicate that atrophy of the left dorsolateral prefrontal cortex contributes to the impairment of verbal fluency in elderly female patients with stroke. Sex differences may be present in the neuropsychological mechanisms of verbal fluency impairment in patients with stroke.

关键词： neural regeneration neuroimaging brain atrophy verbal fluency executive function stroke sex differences prefrontal cortex dorsolateral prefrontal cortex magnetic resonance imaging grants-supported paper photographs-containing paper neuroregeneration

Neuronal degeneration in the hippocampus and dorsolateral prefrontal cortex in depressive disorder Correlation between ~1H-MRS and Minnesota Multiphasic Personality Inventory

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Neural Regeneration Research 2010年第20期5卷 1587-1591页

作者： Jun Xia Minjie Yang Yi Lei Yicheng Zhou Department of Radiology Second People's Hospital of Shenzhen City Shenzhen 518035 Guangdong Province China Department of Radiology Shenzhen People's Hospital Shenzhen 518020 Guangdong Province China Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

Previous studies using magnetic resonance imaging（MRI）and functional MRI to study depression have primarily focused on proton magnetic resonance spectroscopy（1H-MRS）appearance in various areas of the brain and volume measurements in the limbic ***,results have not been *** the best of our knowledge,very little is known about the relationship between 1H-MRS appearance and depression *** the present study,the relationship between 1H-MRS appearance in depressive patients and Minnesota Multiphasic Personality Inventory-2 scale was *** and 1H-MRS exhibited widened sulci and cisterns,as well as an absence of abnormal signals in depressive *** addition,N-acetyl aspartate/total creatine ratios in bilateral hippocampi and dorsolateral prefrontal cortex were significantly less in depressive patients than in control subjects（P 〈 0.01）.In contrast,choline-containing compounds/total creatine ratios in the dorsolateral prefrontal cortex were significantly greater in depressive patients than in control subjects（P 〈 0.01）.These ratios significantly and positively correlated with patient total depression scores as assessed using the Minnesota Multiphasic Personality Inventory-2 scale（r=0.934 7,0.878 7,P 〈 0.01）.These results suggested that 1H-MRS could be used to reveal a reduced number of neurons in the hippocampus and dorsolateral prefrontal cortex,as well as altered membrane phospholipid metabolism in the dorsolateral prefrontal cortex,in patients with depressive *** mechanisms partially reflected severity of depressive disorder.

关键词： depressive disorder proton magnetic resonance spectroscopy hippocampus dorsolateral prefrontal cortex Minnesota Multiphasic Personality Inventory

Relationships between dorsolateral prefrontal cortex metabolic change and cognitive impairment in first-episode neuroleptic-naive schizophrenia patients

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Relationships between dorsolateral prefrontal cortex metabol...

Theta Oscillations Support prefrontal-hippocampal Interactions in Sequential Working Memory

浙江省神经科学学会第五届学术年会

作者：黄满丽 Thongteck Khoh Shaojia Lu Fen Pan Jinkai Chen Jianbo Hu Shaohua Hu Weijuan Xu Weihua Zhou NingWei Hongli Qi Desheng Shang Yi Xu 浙江大学医学院附属第一医院精神卫生中心浙江大学医学院附属第一医院精神卫生中心浙江省精神障碍诊疗和防治技术重点实验室浙江省医学会精神病学分会青年委员会

The present study aimed to explore the possible associations between the dorsolateral prefrontal cortex(DLPFC) metabolites and the cognitive function in first-episode schizophrenia(FES).This study included 58 patients with FES(29 males and 29 females;mean age,22.66 ± 7.64 years) recruited from the First Affiliated Hospital,College of Medicine,Zhejiang University,and 43 locally recruited healthy controls(16 males and 27 females;mean age,23.07 ± 7.49 years).The single-voxel proton magnetic resonance spectroscopy was used to measure the levels of N-acetylaspartate(NAA),complex of glutamate,glutamine,and y-aminobutyric acid(Glx),choline-containing compounds and myo-inositol in the *** ratios of metabolites to creatine(Cr) were *** cognitive function was assessed by Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS) Consensus Cognitive Battery(MCCB).Correlation analysis was used to assess the relationships between the DLPFC metabolites and the cognitive *** with the healthy controls,the patients with FES showed significantly reduced scores in each part of the MCCB,significantly reduced NAA/Cr,and significantly increased Glx/Cr in the left *** performance in verbal learning and visual learning was correlated to the reduced NAA/Cr ratio in the left *** findings suggest that a lower NAA/Cr ratio in the left DLPFC is associated with the cognitive deficits in patients with FES,and may be an early biochemical marker for the cognitive impairment in schizophrenia.

关键词： Cognition first-episode schizophrenia dorsolateral prefrontal cortex 1H-MRS MCCB

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Neuroscience Bulletin 2024年第2期40卷 147-156页

作者： Minghong Su Kejia Hu Wei Liu Yunhao Wu Tao Wang Chunyan Cao Bomin Sun Shikun Zhan Zheng Ye Institute of Psychology Chinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Department of Neurosurgery Center for Functional NeurosurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Neuroscience Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China

The prefrontal cortex and hippocampus may support sequential working memory beyond episodic memory and spatial *** stereoelectroencephalography(SEEG)study investigated how the dorsolateral prefrontal cortex(DLPFC)interacts with the hippocampus in the online processing of sequential *** patients with epilepsy(eight women,age 27.6±8.2 years)completed a line ordering task with SEEG recordings over the DLPFC and the *** showed longer thinking times and more recall errors when asked to arrange random lines clockwise(random trials)than to maintain ordered lines(ordered trials)before recalling the orientation of a particular ***,the ordering-related increase in thinking time and recall error was associated with a transient theta power increase in the hippocampus and a sustained theta power increase in the DLPFC(3–10 Hz).In particular,the hippocampal theta power increase correlated with the memory precision of line ***,theta phase coherences between the DLPFC and hippocampus were enhanced for ordering,especially for more precisely memorized ***,the theta band DLPFC→hippocampus influence was selectively enhanced for ordering,especially for more precisely memorized *** study suggests that theta oscillations may support DLPFC-hippocampal interactions in the online processing of sequential information.

关键词： Sequential working memory Hippocampus dorsolateral prefrontal cortex Theta oscillations Stereoelectroencephalography(SEEG) Phase coherence Granger causality

Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Psychiatry 2024年第4期14卷 334-346页

作者： Tomoko Uchida Daisuke Matsuzawa Tadashi Shiohama Katsunori Fujii Akihiro Shiina Masamitsu Naka Katsuo Sugita Eiji Shimizu Naoki Shimojo Hiromichi Hamada Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan Research Center for Child Mental Development Chiba University Chiba Japan Division of Medical Care and Treatment Center for Forensic Mental Health Chiba University Chiba Japan Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan

Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments.

关键词： Working Memory Attention-Deficit/Hyperactivity Disorder dorsolateral prefrontal cortex Transcranial Direct Current Stimulation

Transcranial direct current stimulation for auditory verbal hallucinations:a systematic review of clinical trials

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Neural Regeneration Research 2021年第4期16卷 666-671页

作者： Samaneh Rashidi Myles Jones Eric Murillo-Rodriguez Sergio Machado Youguo Hao Ali Yadollahpour Department of Medical Physics School of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Psychology University of SheffieldSheffieldUK Laboratorio de Neurociencias Moleculares e Integrativas Escuela de Medicina División Ciencias de la SaludUniversidad Anáhuac MayabMéridaYucatánMéxico Laboratory of Physical Activity Neuroscience Physical Activity Sciences Postgraduate ProgramSalgado de Oliveira UniversityNiteróiBrazil Department of Rehabilitation Shanghai Putuo People’s HospitalShanghaiChina

Transcranial direct current stimulation(tDCS)has been reportedly beneficial for different neurodegenerative *** has been reported as a potential adjunctive or alternative treatment for auditory verbal hallucination(AVH).This study aims to review the effects of tDCS on AVH in patients with schizophrenia through combining the evidence from randomized clinical trials(RCTs).The databases of PsycINFO(2000–2019),PubMed(2000–2019),EMBASE(2000–2019),CINAHL(2000–2019),Web of Science(2000–2019),and Scopus(2000–2019)were systematically *** clinical trials with RCT design were selected for final analysis.A total of nine RCTs were eligible and included in the *** RCTs were included in the final *** them,six RCTs reported a significant reduction of AVH after repeated sessions of tDCS,whereas three RCTs did not show any advantage of active tDCS over sham *** current studies showed an overall decrease of approximately 28%of AVH after active tDCS and 10%after sham *** tDCS protocols targeting the sensorimotor frontal-parietal network showed greater treatment effects compared with the protocols targeting other *** this regard,cathodal tDCS over the left temporoparietal area showed inhibitory effects on *** most effective tDCS protocol on AVHs was twice-daily sessions(2 mA,20-minute duration)over 5 consecutive days(10 sessions)with the anode over the left dorsolateral prefrontal cortex and the cathode over the left temporal *** patient-specific and diseasespecific factors such as young age,nonsmoking status,and higher frequencies of AVHs seemed to be the predictors of treatment *** together,the results of tDCS as an alternative treatment option for AVH show controversy among current literatures,since not all studies were ***,the studies targeting the same site of the brain showed that the tDCS could be a promising treatment option to reduce *** RCTs,with larger sample sizes,should be con

关键词： auditory verbal hallucinations dorsolateral prefrontal cortex effective protocol randomized clinical trial,schizophrenia temporoparietal area transcranial direct current stimulation treatment efficacy

Transcriptomic analyses of humans and mice provide insights into depression

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Zoological Research 2020年第6期41卷 632-643页

作者： Hui-Juan Li Xi Su Lu-Wen Zhang Chu-Yi Zhang Lu Wang Wen-Qiang Li Yong-Feng Yang Lu-Xian Lv Ming Li Xiao Xiao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Henan Mental Hospital Second Affiliated Hospital of Xin xiang Medical UniversityXinxiangHenan 453002China Henan Key Lab of Biological Psychiatry International Joint Research Laboratory for Psychiatry and Neuroscience of HenanXinxiang Medical UniversityXinxiangHenan 453002China Henan Province People's Hospital ZhengzhouHenan 450003China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

Accumulating studies have been conducted to identify risk genes and relevant biological mechanisms underlying major depressive disorder(MDD).In particular,transcriptomic analyses in brain regions engaged in cognitive and emotional processes,e.g.,the dorsolateral prefrontal cortex(DLPFC),have provided essential *** on three independent DLPFC RNA-seq datasets of 79 MDD patients and 75 healthy controls,we performed differential expression analyses using two alternative approaches for *** also conducted transcriptomic analyses in mice undergoing chronic variable stress(CVS)and chronic social defeat stress(CSDS).We identified 12 differentially expressed genes(DEGs)through both analytical methods in MDD patients,the majority of which were also dysregulated in stressed ***,the mRNA level of the immediate early gene FOS(Fos proto-oncogene)was significantly decreased in both MDD patients and CVS-exposed mice,and CSDSsusceptible mice exhibited a greater reduction in Fos expression compared to resilient *** findings suggest the potential key roles of this gene in the pathogenesis of MDD related to stress *** transcriptomes in the DLPFC of MDD patients might be,at least partially,the result of stress exposure,supporting that stress is a primary risk factor for MDD.

关键词： Major depressive disorder Stressed mice dorsolateral prefrontal cortex Transcriptomic analysis FOS

Transcranial Direct Current Stimulation in ADHD:A Systematic Review of Efficacy,Safety,and Protocol-induced Electrical Field Modeling Results

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Neuroscience Bulletin 2020年第10期36卷 1191-1212页

作者： Mohammad Ali Salehinejad Vahid Nejati Mohsen Mosayebi-Samani Ali Mohammadi Miles Wischnewski Min-Fang Kuo Alessio Avenanti Carmelo M・Vicario Michael A.Nitsche Department of Psychology and Neurosciences Leibniz Research Centre for Working Environment and Human Factors44139 DortmundGermany International Graduate School of Neuroscience Ruhr-University Bochum44801 BochumGermany Institute for Cognitive and Brain Sciences Shahid Beheshti UniversityTehran ***Iran Department of Psychology Shahid Beheshti UniversityTehran ***Iran Institute of Biomedical Engineering and Informatics Ilmenau University of Technology98693 IlmenauGermany Donders Institute for Brain Cognition and BehaviourRadboud University6525 HR NijmegenThe Netherlands Centro studi e ricerche in Neuroscienze Cognitive Dipartimento di PsicologiaAlma Mater StudiormUniversita di Bologna47521 CesenaItaly Centro de Investigacion en Neuropsicologia y Neurociencias Cognitivas Universidad Catolica del Maule3605 TalcaChile Dipartimento di Scienze Cognitive PsicologichePedagogiche e degli studi culturaliUniversita di Messina98121 MessinaItaly Department of Neurology University Medical Hospital Bergmannsheil44789 BochumGermany

Transcranial direct current stimulation(tDCS)is a promising method for altering cortical excitability with clinical *** has been increasingly used in neurodevelopmental disorders,especially attention-deficit hyperactivity disorder(ADHD),but its efficacy(based on effect size calculations),safety,and stimulation parameters have not been systematically *** this systematic review,we aimed to(1)explore the effectiveness of tDCS on the clinical symptoms and neuropsychological deficits of ADHD patients,(2)evaluate the safety of tDCS application,especially in children with ADHD,(3)model the electrical field intensity in the target regions based on the commonly-applied and effective versus less-effective protocols,and(4)discuss and propose advanced tDCS *** the Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach,a literature search identified 14 empirical experiments investigating tDCS effects in *** improving effects of tDCS on cognitive deficits(response inhibition,working memory,attention,and cognitive flexibility)or clinical symptoms(e.g.,impulsivity and inattention)are reported in10 *** serious adverse effects are reported in 747 sessions of *** left and right dorsolateral prefrontal cortex are the regions most often targeted,and anodal tDCS the protocol most often *** intensity of 2 mA induced stronger electrical fields than 1 mA in adults with ADHD and was associated with significant behavioral *** ADHD children,however,the electrical field induced by 1 mA,which is likely larger than the electrical field induced by 1 mA in adults due to the smaller head size of children,was sufficient to result in significant behavioral ***,tDCS seems to be a promising method for improving ADHD ***,the clinical utility of tDCS in ADHD cannot yet be concluded and requires further systematic investigation in larger sample *** regions involved in ADHD pathophysio

关键词： Transcranial direct current stimulation Attention-deficit hyperactivity disorder dorsolateral prefrontal cortex Executive function Systematic review Brain modeling Non-invasive brain stimulation Pediatric

ZNF804A Variation May Affect Hippocampal-prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals

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Neuroscience Bulletin 2018年第3期34卷 507-516页

作者： Yuyanan Zhang Hao Yan Jinmin Liao Hao Yu Sisi Jiang Qi Liu Dai Zhang Weihua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191 China Key Laboratory of Mental Health Ministry of Health and National Clinical Research Center for Mental Disorders(Peking University) Beijing 100191 China Department of Psychiatry Jining Medical UniversityJining 272067 China Peking-Tsinglaua Joint Center for Life Sciences and PKUIDG/McGovern Institute for Brain Research Peking University Beijing 100871 China

The ZNF804 A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting state and in patients with schizophrenia remains unclear. In this study, we investigated the ZNF804 A polymorphism at rs1344706 in 92 schizophrenic patients and 99 healthy controls of Han Chinese descent, and used resting-state functional magnetic resonance imaging to explore the functional connectivity in the participants. We found a significant main effect of genotype on the resting-state functional connectivity（RSFC） between the hippocampus and the dorsolateral prefrontal cortex（DLPFC） in both schizophrenic patients and healthy controls. The homozygous ZNF804 A rs1344706 genotype（AA） conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC（F（2,165） = 13.43,P ／ 0.001）. The RSFC strength was also correlated with cognitive performance and the severity of psychosis in schizophrenia. The current findings identified the neural impact of the ZNF804 A rs1344706 on hippocampalprefrontal RSFC associated with schizophrenia.

关键词： Schizophrenia ZNF804A Imaging genetics Hippocampus dorsolateral prefrontal cortex