Transcranial direct current stimulation for auditory verbal hallucinations:a systematic review of clinical trials

作     者：Samaneh Rashidi Myles Jones Eric Murillo-Rodriguez Sergio Machado Youguo Hao Ali Yadollahpour Samaneh Rashidi;Myles Jones;Eric Murillo-Rodriguez;Sergio Machado;Youguo Hao;Ali Yadollahpour

作者机构：Department of Medical PhysicsSchool of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Department of PsychologyUniversity of SheffieldSheffieldUK Laboratorio de Neurociencias Moleculares e IntegrativasEscuela de Medicina División Ciencias de la SaludUniversidad Anáhuac MayabMéridaYucatánMéxico Laboratory of Physical Activity NeurosciencePhysical Activity Sciences Postgraduate ProgramSalgado de Oliveira UniversityNiteróiBrazil Department of RehabilitationShanghai Putuo People’s HospitalShanghaiChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第4期

页      面：666-671页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：auditory verbal hallucinations dorsolateral prefrontal cortex effective protocol randomized clinical trial,schizophrenia temporoparietal area transcranial direct current stimulation treatment efficacy 

摘      要：Transcranial direct current stimulation(tDCS)has been reportedly beneficial for different neurodegenerative *** has been reported as a potential adjunctive or alternative treatment for auditory verbal hallucination(AVH).This study aims to review the effects of tDCS on AVH in patients with schizophrenia through combining the evidence from randomized clinical trials(RCTs).The databases of PsycINFO(2000–2019),PubMed(2000–2019),EMBASE(2000–2019),CINAHL(2000–2019),Web of Science(2000–2019),and Scopus(2000–2019)were systematically *** clinical trials with RCT design were selected for final analysis.A total of nine RCTs were eligible and included in the *** RCTs were included in the final *** them,six RCTs reported a significant reduction of AVH after repeated sessions of tDCS,whereas three RCTs did not show any advantage of active tDCS over sham *** current studies showed an overall decrease of approximately 28%of AVH after active tDCS and 10%after sham *** tDCS protocols targeting the sensorimotor frontal-parietal network showed greater treatment effects compared with the protocols targeting other *** this regard,cathodal tDCS over the left temporoparietal area showed inhibitory effects on *** most effective tDCS protocol on AVHs was twice-daily sessions(2 mA,20-minute duration)over 5 consecutive days(10 sessions)with the anode over the left dorsolateral prefrontal cortex and the cathode over the left temporal *** patient-specific and diseasespecific factors such as young age,nonsmoking status,and higher frequencies of AVHs seemed to be the predictors of treatment *** together,the results of tDCS as an alternative treatment option for AVH show controversy among current literatures,since not all studies were ***,the studies targeting the same site of the brain showed that the tDCS could be a promising treatment option to reduce *** RCTs,with larger sample sizes,should be con