ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals

作     者：Yuyanan Zhang Hao Yan Jinmin Liao Hao Yu Sisi Jiang Qi Liu Dai Zhang Weihua Yue 

作者机构：Institute of Mental Health Peking University Sixth HospitalBeijing 100191 China Key Laboratory of Mental Health Ministry of Health and National Clinical Research Center for Mental Disorders(Peking University) Beijing 100191 China Department of Psychiatry Jining Medical UniversityJining 272067 China Peking-Tsinglaua Joint Center for Life Sciences and PKUIDG/McGovern Institute for Brain Research Peking University Beijing 100871 China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2018年第34卷第3期

页      面：507-516页

核心收录：

学科分类：0710[理学-生物学] 083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 100205[医学-精神病与精神卫生学] 10[医学] 0713[理学-生态学] 

基　　金：supported by the National Key Research and Development Program of China (2016YFC1307000 and 2015BAI13B01) the National Natural Science Foundation of China (91432304, 81370032, 81571313 and 81221002) Capital Health Development Research (2016-2-4112) Beijing Nova Program Interdisciplinary Studies Cooperative Project (Z161100004916038) 

主　　题：Schizophrenia ZNF804A Imaging genetics Hippocampus Dorsolateral prefrontal cortex 

摘      要：The ZNF804 A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting state and in patients with schizophrenia remains unclear. In this study, we investigated the ZNF804 A polymorphism at rs1344706 in 92 schizophrenic patients and 99 healthy controls of Han Chinese descent, and used resting-state functional magnetic resonance imaging to explore the functional connectivity in the participants. We found a significant main effect of genotype on the resting-state functional connectivity（RSFC） between the hippocampus and the dorsolateral prefrontal cortex（DLPFC） in both schizophrenic patients and healthy controls. The homozygous ZNF804 A rs1344706 genotype（AA） conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC（F（2,165） = 13.43,P ／ 0.001）. The RSFC strength was also correlated with cognitive performance and the severity of psychosis in schizophrenia. The current findings identified the neural impact of the ZNF804 A rs1344706 on hippocampalprefrontal RSFC associated with schizophrenia.