Transcriptomic analyses of humans and mice provide insights into depression

作     者：Hui-Juan Li Xi Su Lu-Wen Zhang Chu-Yi Zhang Lu Wang Wen-Qiang Li Yong-Feng Yang Lu-Xian Lv Ming Li Xiao Xiao Hui-Juan Li;Xi Su;Lu-Wen Zhang;Chu-Yi Zhang;Lu Wang;Wen-Qiang Li;Yong-Feng Yang;Lu-Xian Lv;Ming Li;Xiao Xiao

作者机构：Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan ProvinceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life ScienceUniversity of Chinese Academy of SciencesKunmingYunnan 650204China Henan Mental HospitalSecond Affiliated Hospital of Xin xiang Medical UniversityXinxiangHenan 453002China Henan Key Lab of Biological PsychiatryInternational Joint Research Laboratory for Psychiatry and Neuroscience of HenanXinxiang Medical UniversityXinxiangHenan 453002China Henan Province People's HospitalZhengzhouHenan 450003China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China 

出 版 物：《Zoological Research》 (动物学研究（英文）)

年 卷 期：2020年第41卷第6期

页      面：632-643页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the Chinese Academy of Sciences(CAS)Western Light Program CAS Youth Innovation Promotion Association to X.X the CAS Pioneer Hundred Talents Program and 1000 Young Talents Program to M.L 

主　　题：Major depressive disorder Stressed mice Dorsolateral prefrontal cortex Transcriptomic analysis FOS 

摘      要：Accumulating studies have been conducted to identify risk genes and relevant biological mechanisms underlying major depressive disorder(MDD).In particular,transcriptomic analyses in brain regions engaged in cognitive and emotional processes,e.g.,the dorsolateral prefrontal cortex(DLPFC),have provided essential *** on three independent DLPFC RNA-seq datasets of 79 MDD patients and 75 healthy controls,we performed differential expression analyses using two alternative approaches for *** also conducted transcriptomic analyses in mice undergoing chronic variable stress(CVS)and chronic social defeat stress(CSDS).We identified 12 differentially expressed genes(DEGs)through both analytical methods in MDD patients,the majority of which were also dysregulated in stressed ***,the mRNA level of the immediate early gene FOS(Fos proto-oncogene)was significantly decreased in both MDD patients and CVS-exposed mice,and CSDSsusceptible mice exhibited a greater reduction in Fos expression compared to resilient *** findings suggest the potential key roles of this gene in the pathogenesis of MDD related to stress *** transcriptomes in the DLPFC of MDD patients might be,at least partially,the result of stress exposure,supporting that stress is a primary risk factor for MDD.