Neuronal degeneration in the hippocampus and dorsolateral prefrontal cortex in depressive disorder Correlation between ~1H-MRS and Minnesota Multiphasic Personality Inventory

作     者：Jun Xia Minjie Yang Yi Lei Yicheng Zhou 

作者机构：Department of Radiology Second People's Hospital of Shenzhen City Shenzhen 518035 Guangdong Province China Department of Radiology Shenzhen People's Hospital Shenzhen 518020 Guangdong Province China Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2010年第5卷第20期

页      面：1587-1591页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 071002[理学-动物学] 

主　　题：depressive disorder proton magnetic resonance spectroscopy hippocampus dorsolateral prefrontal cortex Minnesota Multiphasic Personality Inventory 

摘      要：Previous studies using magnetic resonance imaging（MRI）and functional MRI to study depression have primarily focused on proton magnetic resonance spectroscopy（1H-MRS）appearance in various areas of the brain and volume measurements in the limbic ***,results have not been *** the best of our knowledge,very little is known about the relationship between 1H-MRS appearance and depression *** the present study,the relationship between 1H-MRS appearance in depressive patients and Minnesota Multiphasic Personality Inventory-2 scale was *** and 1H-MRS exhibited widened sulci and cisterns,as well as an absence of abnormal signals in depressive *** addition,N-acetyl aspartate/total creatine ratios in bilateral hippocampi and dorsolateral prefrontal cortex were significantly less in depressive patients than in control subjects（P 〈 0.01）.In contrast,choline-containing compounds/total creatine ratios in the dorsolateral prefrontal cortex were significantly greater in depressive patients than in control subjects（P 〈 0.01）.These ratios significantly and positively correlated with patient total depression scores as assessed using the Minnesota Multiphasic Personality Inventory-2 scale（r=0.934 7,0.878 7,P 〈 0.01）.These results suggested that 1H-MRS could be used to reveal a reduced number of neurons in the hippocampus and dorsolateral prefrontal cortex,as well as altered membrane phospholipid metabolism in the dorsolateral prefrontal cortex,in patients with depressive *** mechanisms partially reflected severity of depressive disorder.