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Basal Serum Anti-Miillerian Hormone Level as a Predictor of Clinical Outcomes in Freezing-all Embryo Transfer Program

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Current Medical Science 2018年第5期38卷 861-867页

作者： xiao-lan li Rui HUANG Cong FANG xiao-yan liANG Reproductive Medicine Research Center Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China

As a novel biomarker,there is inconsistent evidence regarding the association between anti-Miillerian hormone (AMH) and live birth rate in freezing-all embryo transfer *** aim to assess the prognostic effect of baseline AMH on clinical outcomes,especially live birth rate in freezing-all embryo transfer cycles.A total of 828 non-polycystic ovary patients that underwent their first frozen-thawed embryo transfers in our center between January 2010 and January 2015 were recruited in this retrospective *** were stratified into three groups based on their baseline AMH concentration:low AMH group (5.8 ng/mL).The results showed that low AMH level was associated With adverse clinical *** differences in implantation rate (21.9% vs.43.2% vs.58.8%,Plinical pregnancy rate (32.0% vs.55.2% vs.65.7%, Plive birth delivery rate (21.8% vs.43.6% vs.52.7%,Pline FSH level,AFC,endometrium thickness,endometriurn preparation protocols,number of embryos transferred,etiologies of infertility),differences in live birth rate,clinical pregnancy rate and implantation rate between groups remained *** further age subgroup analysis demonstrated that low AMH concentration was significantly associated with poor outcomes both in young and advanced *** area under the curve for serum AMH,age,AFC and FSH were 0.635,0.634,0.615 and 0.543 respectively,for predicting live *** conclusion, baseline AMH was an independent prognostic factor of live birth rate of freezing-all embryo transfers,but its predictive value on live birth rate was of limited clinical value.

关键词： anti-Miillerian hormone freezing-all embryo transfer live birth rate

Determination of synthetic phenolic antioxidants in essence perfume by high performance liquid chromatography with vortex-assisted,cloud-point extraction using AEO-9

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Chinese Chemical Letters 2014年第8期25卷 1198-1202页

作者： xiao-lan li Dong-ling Meng Jiao Zhao Ya-ling Yang Technology Centre of China Tobacco Guangxi Industrial Co. Ltd. College of life Science and Technology Kunming University of Science and Technology

This study aimed to establish a rapid analytical method to determine antioxidants in essence. A simple,efficient and practical, vortex-assisted, cloud-point extraction（VACPE） procedure is proposed for extracting and pre-concentrating four different of synthetic phenolic antioxidants（SPAs）, propyl gallate（PG）, tert-butylhydroquinone（TBHQ）, butylated hydroxyanisole（BHA）, butylated hydroxytoluene（BHT） in essence prior to high performance liquid chromatography（HPLC） analysis. The non-ionic surfactant, fatty alcohol polyoxyethylene ether-9（AEO-9）, was used as extractant and vortex-mixing was utilized to reduce extraction time and improve extraction efficiency. The effective parameters of the extraction process, such as volume of extraction solvent, pH, vortex-mixing time, equilibration temperature and time, were optimized. Under the optimum conditions, the linear range of PG, TBHQ,BHA and BHT was 8.0–800 ng/mL. All correlation coefficients of the calibration curves were higher than0.996 and relative standard deviations（RSD, n = 5） were 2.36%–5.46%. The proposed method was successfully applied to the extraction and determination of antioxidants in essence samples with satisfactory relative recoveries of 89.4%–103.5%. The results confirmed the SPAs of essence could be effectively monitored by this method and also established good reference criteria for essence.

关键词： Vortex-assisted cloud-point extraction AEO-9 Antioxidant High performance liquid chromatography Essence

Resonance light Scattering Method for Determination of Amikacin with Potassium Ferrioxalate as a Probe

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Chemical Research in Chinese Universities 2010年第3期26卷 366-370页

作者： HU xiao-li AN lan-xiang liU Shao-pu liU Zhong-fang li Cui-xia Key Laboratory of Luminescence and Real-Time Analysis Ministry of Education School of Chemistry and Chemical Engineering Southwest University Chongqing 400715 P. R. China

In a weak acid medium, potassium ferrioxalate（PF） can react with some aminoglycoside（AGs） antibiotics, such as amikacin（AMK）, kanamycin（KANA）, tobramycin（TOB） and gentamicin（GEN）, to form ion-association complexes. It results in the enhancement of resonance light scattering（RLS） in different degrees. The maximum scattering peaks are all located at 345 nm. Among them, the relative scattering intensity（AIRLs） of AMK system is much higher than that of KANA, TOB or GEN. Therefore the method is more propitious to the determination of trace amounts of AMK. The optimum reaction conditions, influencing factors, and the relationship between scattering intensity and concentration of antibiotics were investigated by means of the proposed method. The enhancement of RLS signals is directly proportional to the concentration of antibiotics in a certain range of concentration. A new resonance light scattering method for the determination of AMK and other aminoglycoside antibiotics with [Fe（C2O4）3]^3- as a probe is thus established based on it. The method exhibits high sensitivity and good selectivity. The detection limit（3σ） for AMK is 1.8 ng/mL. The method can be applied to the determination of AMK in clinical serum samples. The reaction mechanism and the reasons for RLS enhancement are discussed in this paper.

关键词： Resonance light scattering Amikacin Aminoglycoside antibiotics Potassium ferrioxalate

Whole Body Positron Emission Tomography/Computed Tomography （PET/CT） in the Evaluation of Ophthalmic Tumors

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Current Medical Science 2018年第2期38卷 310-317页

作者： Ping JIANG Shan-shan liAO xiao-li lan Fa-gang JIANG Department of Ophthalmology Union Hospital Tongii Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Nuclear Medicine and PET Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

The clinical value of whole body positron emission tomography/computed tomography （PET/CT） as an imaging tool in diagnosis of ophthalmic tumors was investigated. The retrospective observational case series were performed on the patients with suspected ophthalmic tumors who underwent whole body PET/CT. The golden standard of diagnosis was the final pathological diagnosis or the results of long-term follow-up for patients without surgery/ biopsy. PET/CT findings were compared with the golden standard. The sensitivity, specificity, accuracy an^t positive likelihood ratio of PET/CT in the detection of ophthalmic tumors were calculated. The clinical application of PET/CT in different types of ophthalmic tumors was evaluated. The results showed that 30 patients （18 males and 12 females） with a mean age of 43.0 years （range 4-63 years） were collected. The mean sizes of orbital tumors and intraocular tumors were 26.8 mmxl7.8 mm and 11.2 minx6.1 mm, respectively. The overall sensitivity, specificity, accuracy and positive likelihood ratio of whole body PET/CT in ophthalmic tumors were 76.5%, 71.4%, 75.0% and 2.67, and were 62.5%, 100% and 70.0% in intraocular tumors, and those were 100%, 60.0% and 84.6% in orbital tumors, respectively. PET/CT findings were applied to help make appropriate treatment options in 27 out of 30 patients （90.0%）, and 12 （40.0%） patients changed the treatment strategy. False negative results in 4 cases and false positive results in 2 cases were observed in this series. It was suggested that PET/CT was an effective imaging modality in detecting, diagnosing and developing therapeutic schedule for patients with ophthalmic tumors. It was more sensitive and accurate for detecting orbital tumors than for detecting intraocular tumors.

关键词： positron emission tomography/computed tomography ophthalmic tumor orbital tumor ocular tumor

p53 mutations in colorectal cancer-molecular pathogenesis and pharmacological reactivation

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World Journal of Gastroenterology 2015年第1期21卷 84-93页

作者： xiao-lan li Jianbiao Zhou Zhi-Rong Chen Wee-Joo Chng Cancer Science Institute of Singapore National University of Singapore14 Medical DriveCentre for Translational Medicine Department of Gastroenterology Suzhou Municipal Hospital(Eastern) Department of Medicine Yong Loo Lin School of MedicineNational University of Singapore Department of Hematology-Oncology National University Hospital Singapore

Colorectal cancer(CRC) is one of the most common malignancies with high prevalence and low 5-year *** is a heterogeneous disease with a complex,genetic and biochemical *** is now generally accepted that a few important intracellular signaling pathways,including Wnt/β-catenin signaling,Ras signaling,and p53 signaling are frequently dysregulated in *** with mutant p53 gene are often resistant to current therapies,conferring poor *** suppressor p53 protein is a transcription factor inducing cell cycle arrest,senescence,and apoptosis under cellular *** evidence from laboratories and clinical trials shows that some small molecule inhibitors exert anti-cancer effect via reactivation and restoration of p53 *** this review,we summarize the p53 function and characterize its mutations in *** involvement of p53 mutations in pathogenesis of CRC and their clinical impacts will be ***,we also describe the current achievements of using p53 modulators to reactivate this pathway in CRC,which may have great potential as novel anti-cancer therapy.

关键词： Colorectal cancer p53 Tumor suppressor Small molec

Air pollution and meteorological conditions significantly contribute to the worsening of allergic conjunctivitis:a regional 20-city,5-year study in Northeast China

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light(Science & Applications) 2021年第11期10卷 2128-2142页

作者： Cheng-Wei Lu Jing Fu Xiu-Fen liu Wei-Wei Chen Ji-Long Hao xiao-lan li Om Prakash Pant The Department of Ophthalmology The First Hospital of Jilin UniversityChangchun130021China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun130102China Institute of Atmospheric Environment China Meteorological AdministrationShenyang110166China Dhangadhi Netralaya Eye Hospital Dhangadhi3KailaliNepal

This study is the first to explore the potential associations among allergic conjunctivitis(AC),air pollution,and meteorological conditions in Northeast *** of meteorology,ambient atmospheric pollutants,and the incidence of allergic conjunctivitis(IAC)in prefecture-level cities between the years 2014 and 2018 are *** results show an increasing trend in the AC of average growth rate per annum 7.6%,with the highest incidence in the provincial *** IAC is positively correlated with atmospheric pollutants(i.e.,PM_(2.5),PM_(10),CO,SO_(2),NO_(2),and O_(3))and meteorological factors(i.e.,air temperature and wind speed),but negatively correlated with relative *** results suggest that the IAC is directly proportional to pollution level and climatic conditions,and also the precedence of air *** have further obtained the threshold values of atmospheric pollutants concentration and meteorological factors,a turning point above which more AC may be *** with the air quality standard advised by China and the World Health Organization(WHO),both thresholds of PM_(10)(70μg m^(-3))and PM_(2.5)(45μg m^(-3))are higher than current standards and pose a less environmental risk for the ***_(2) threshold(23μg m^(-3))is comparable to the WHO standard and significantly lower than that of China’s,indicating greater environmental risks in *** thresholds of NO_(2)(27μg m^(-3))and O_(3)(88μg m^(-3))are below current standards,indicating that they are major environmental risk factors for the *** findings highlight the importance of atmospheric environmental protection and reference for health-based amendment.

关键词： allergic meteorological pollution

Impacts of air pollution and meteorological conditions on dry eye disease among residents in a northeastern Chinese metropolis:a six-year crossover study in a cold region

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light(Science & Applications) 2023年第9期12卷 1757-1770页

作者： Cheng-Wei Lu Jing Fu Xiu-Fen liu Zhi-Hua Cui Wei-Wei Chen li Guo xiao-lan li Yu Ren Fei Shao li-Na Chen Ji-Long Hao Opthalmology Department The First Hospital of Jilin UniversityChangchun 130021China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China College of New Energy and Environment Jilin UniversityChangchun 130021China China College of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China Shenyang Institute of Atmospheric Environment China Meteorological AdministrationShenyang 110166China

The purpose of this study is to explore the associations among dry eye disease(DED),air pollution,and meteorological conditions in the cold region of a northeastern Chinese metropolis(i.e.,Changchun).Data on ambient air pollutants and meteorological parameters as well as diagnosed DED outpatients during 2015–2021 were *** associations between DED and environmental factors were analysed at multiple time scales using various statistical methods(i.e.,correlation,regression and machine learning).Among the 10,809 DED patients(21,617 eyes)studied,64.60%were female and 35.40%were male.A higher frequency of DED was observed in March and April,followed by January,August and *** and multiple factor models showed the positive importance of particles with aerodynamic diameterslighting the importance of coordinated policies in air pollution control and climate change mitigation.

关键词： pollution meteorological northeastern

First platelet transfusion refractoriness in a patient with acute myelocytic leukemia: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7156-7161页

作者： Sheng-Ke Tu Hong-Jie Fan Zi-Wei Shi xiao-lan li Min li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Platelet transfusion is of great significance in the treatment of thrombocytopenia caused by myelosuppression during intensive chemotherapy in patients with acute *** recent years,with platelet transfusion increasing,ineffective platelet transfusion has become increasingly *** speaking,platelet antibodies can be produced after repeated transfusion,thus rendering subsequent platelet transfusion *** report a case of first platelet transfusion refractoriness(PTR)in a patient with acute myelocytic leukemia(AML).Due to the rarity of such cases in clinical practice,there have been no relevant case reports so *** SUMMARY A 51-year-old female patient attended the hospital due to throat pain and abnormal blood cells for 4 *** diagnosis was acute myelocytic leukemia[M2 type Fms related receptor tyrosine kinase 3,Isocitrate Dehydrogenase 1,Nucleophosmin 1,Neuroblastoma RAS viral oncogene homolog(+)high-risk group].She was treated with"IA"(IDA 10 mg day 1-3 and Ara-C 0.2 g day 1-5)*** her condition improved,the patient was discharged from the hospital,instructed to take medicine as prescribed by the doctor after discharge,and returned to the hospital for further chemotherapy on *** We report a rare case of first platelet transfusion failure in a patient with AML during induction chemotherapy,which may be related to the production of platelet antibodies induced by antibiotics and excessive tumor *** also suggests that we should consider the influence of antibiotics when the rare situation of first platelet transfusion failure occurs in patients with *** platelet antibodies are produced,immunoglobulins can be used to block antibodies,thereby reducing platelet *** patients with PTR,both immune and non-immune factors need to be considered and combined in clinical practice along with individualized treatment to effectively solve the problem.

关键词： Acute myelocytic leukemia First platelet transfusion refractoriness Myelosuppression Nonimmune causes Immune-mediated causes Case report

Medcheck:A novel software for automated de-formulation of traditional Chinese medicine(TCM)prescriptions by liquid chromatography-mass spectrometry

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Journal of Pharmaceutical Analysis 2024年第6期14卷 930-932页

作者： xiao-lan li Jian-qing Zhang Yun li Xuan-jing Shen Huan-ya Yang lin Yang Meng Xu Qi-rui Bi Chang-liang Yao De-an Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China b University of Chinese Academy of Sciences Beijing100049China

Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical formulas”is recently developed and expected to boom in the *** constituent me-dicinal plants in prescriptions is critical for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.

关键词： medicines formulation prescription