Basal Serum Anti-Miillerian Hormone Level as a Predictor of Clinical Outcomes in Freezing-all Embryo Transfer Program
作者机构：Reproductive Medicine Research CenterSixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2018年第38卷第5期
页 面：861-867页
核心收录：
学科分类：10[医学]
主 题：anti-Miillerian hormone freezing-all embryo transfer live birth rate
摘 要：As a novel biomarker,there is inconsistent evidence regarding the association between anti-Miillerian hormone (AMH) and live birth rate in freezing-all embryo transfer *** aim to assess the prognostic effect of baseline AMH on clinical outcomes,especially live birth rate in freezing-all embryo transfer cycles.A total of 828 non-polycystic ovary patients that underwent their first frozen-thawed embryo transfers in our center between January 2010 and January 2015 were recruited in this retrospective *** were stratified into three groups based on their baseline AMH concentration:low AMH group (5.8 ng/mL).The results showed that low AMH level was associated With adverse clinical *** differences in implantation rate (21.9% vs.43.2% vs.58.8%,P0.001),clinical pregnancy rate (32.0% vs.55.2% vs.65.7%, P0.001),live birth delivery rate (21.8% vs.43.6% vs.52.7%,P0.001)and miscarriage rate (31.8% vs.17.5% vs.15.4%,P=0.014)among the three groups were statistically *** adjusting confounders (***,baseline FSH level,AFC,endometrium thickness,endometriurn preparation protocols,number of embryos transferred,etiologies of infertility),differences in live birth rate,clinical pregnancy rate and implantation rate between groups remained *** further age subgroup analysis demonstrated that low AMH concentration was significantly associated with poor outcomes both in young and advanced *** area under the curve for serum AMH,age,AFC and FSH were 0.635,0.634,0.615 and 0.543 respectively,for predicting live *** conclusion, baseline AMH was an independent prognostic factor of live birth rate of freezing-all embryo transfers,but its predictive value on live birth rate was of limited clinical value.
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