First platelet transfusion refractoriness in a patient with acute myelocytic leukemia: A case report
作者机构：Department of HematologyThe First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of PharmacyThe First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2023年第11卷第29期
页 面：7156-7161页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Innovation Platform and Talent Program of Hunan Province No.2021SK4050
主 题：Acute myelocytic leukemia First platelet transfusion refractoriness Myelosuppression Nonimmune causes Immune-mediated causes Case report
摘 要：BACKGROUND Platelet transfusion is of great significance in the treatment of thrombocytopenia caused by myelosuppression during intensive chemotherapy in patients with acute *** recent years,with platelet transfusion increasing,ineffective platelet transfusion has become increasingly *** speaking,platelet antibodies can be produced after repeated transfusion,thus rendering subsequent platelet transfusion *** report a case of first platelet transfusion refractoriness(PTR)in a patient with acute myelocytic leukemia(AML).Due to the rarity of such cases in clinical practice,there have been no relevant case reports so *** SUMMARY A 51-year-old female patient attended the hospital due to throat pain and abnormal blood cells for 4 *** diagnosis was acute myelocytic leukemia[M2 type Fms related receptor tyrosine kinase 3,Isocitrate Dehydrogenase 1,Nucleophosmin 1,Neuroblastoma RAS viral oncogene homolog(+)high-risk group].She was treated withIA(IDA 10 mg day 1-3 and Ara-C 0.2 g day 1-5)*** her condition improved,the patient was discharged from the hospital,instructed to take medicine as prescribed by the doctor after discharge,and returned to the hospital for further chemotherapy on *** We report a rare case of first platelet transfusion failure in a patient with AML during induction chemotherapy,which may be related to the production of platelet antibodies induced by antibiotics and excessive tumor *** also suggests that we should consider the influence of antibiotics when the rare situation of first platelet transfusion failure occurs in patients with *** platelet antibodies are produced,immunoglobulins can be used to block antibodies,thereby reducing platelet *** patients with PTR,both immune and non-immune factors need to be considered and combined in clinical practice along with individualized treatment to effectively solve the problem.
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