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Atomic-Scale Insights into Damage Mechanisms of GGr15 Bearing Steel Under Cyclic Shear Fatigue

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1265-1278页

作者： qiao-Sheng xia Dong-Peng Hua qing Zhou Ye-Ran shi xiang-Tao Deng Kai-Ju Lu Hai-feng Wang xiu-Bing Liang Zhao-Dong Wang State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an710072China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China Defense Innovation Institute Academy of Military ScienceBeijing100071China

Alternating shear stress is a critical factor in the accumulation of damage during rolling contact fatigue,severely limiting the service life of ***,the specific mechanisms responsible for the cyclic shear fatigue damage in bearing steel have not been fully *** the mechanical response and microstructural evolution of a model GGr15 bearing steel under cyclic shear loading are investigated through the implementation of molecular dynamics *** samples undergo 30 cycles under three different loading conditions with strains of 6.2%,9.2%,and 12.2%,*** findings indicate that severe cyclic shear deformation results in early cyclic softening and significant accumulation of plastic damage in the bearing ***,samples subjected to higher strain-controlled loading exhibit higher plastic strain energy and shorter fatigue ***,strain localization is identified as the predominant damage mechanism in cyclic shear fatigue of the bearing steel,which accumulates and ultimately results in fatigue ***,simulation results also revealed the microstructural reasons for the strain localization(e.g.,BCC phase transformation into FCC and HCP phase),which well explained the formation of white etching *** study provides fresh atomic-scale insights into the mechanisms of cyclic shear fatigue damage in bearing steels.

关键词： Cyclic shear fatigue Molecular dynamic simulation Bearing steels Plastic damage accumulation

Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using （-）-gossypol

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Asian Journal of Andrology 2010年第3期12卷 390-399,I0011页

作者： xian-qing Zhang xiao-feng huang shi-Jie Mu Qun-xing An Ai-Jun xia Rui Chen Dao-Cheng Wu The Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi ＇an Jiaotong University Xi ＇an 710038 China Department of Blood Transfusion Xij＇ing Hospital Xi ＇an 710032 China Central Laboratory Fourth Military Medical University Xi＇an 710032 China

We investigated the antiproliferative activity of （-）-gossypol on the human prostate cancer cell line PC3 in vitro and in vivo to elucidate its potential molecular mechanisms. Cell growth and viability were evaluated using the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay, and cell apoptosis was detected by flow cytometry, terminal deoxynucleotidyl transferase dUTP nick end labelling （TUNEL） and electron microscopy. Expression of proliferating cell nuclear antigen （PCNA）, Bcl-2, CD31, caspase-3 and caspase-8 in tumour tissue was determined by immunohistochemistry. The drug concentration that yielded 50% cell inhibition （IC50 value） was 4.74 μg mL-1. In the PC-3 tumour xenograft study, （-）-gossypol （〉 5 mg kg-1） given once a day for 7 days significantly inhibited tumour growth in a dose-dependent manner. Immunohistochemical analysis revealed that （-）-gossypol enhanced caspase-3 and caspase-8 expression and decreased the expression of PCNA, Bcl-2 and CD31 in tumour tissues. It suggested that cell apoptosis and inhibition of angiogenesis might contribute to the anticancer action of （-）-gossypol.

关键词： apoptosis electron microscopy flow cytometry (-)-gossypol immunohistochemistry prostate cancer

GSPT1 Functions as a Tumor Promoter in Human Liver Cancer

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Current Medical Science 2023年第1期43卷 104-114页

作者： Yi-qing xi Jing-bo GAO Xuan-fei LI Li-hua XU Zhi-LI Li-jie YANG Jing WANG Hua-qiao WANG xiao-chang FANG Si-rui huang Wei xiE Mao-hui feng Jing-wei ZHANG Department of Breast and Thyroid Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Hubei Cancer Clinical Study Center Wuhan UniversityWuhan430071China Institute of Hydrobiology Chinese Academy of SciencesWuhan430071China

Objective This study analyzed the role of G1 to S phase transition 1 protein(GSPT1)in promoting progression of liver cancer *** A bioinformatics database was used to analyze the expression levels of GSPT1 in liver cancer tissues and the prognosis of ***,Western blotting and quantitative PCR were used to verify the expression levels of GSPT1 between normal hepatocytes and hepatoma *** used a CRISPR/Cas9 system to construct knockouts of GSPT1 in HepG2 and HCCLM9 liver cancer *** effect of GSPT1 on liver cancer cell migration and invasion was analyzed using flow cytometry,migration,and tumor formation *** The Cancer Genome Atlas Liver Hepatocellular Carcinoma dataset indicated that GSPT1 expression was upregulated in liver cancer cell lines,and patients with liver cancer had poor *** of GSPT1 in cells significantly inhibited tumor proliferation,cell migration,and growth in *** In this study,we found that GSPT1 promotes the migration and invasion of liver cancer cells.

关键词： Gl to S phase transition I protein liver cancer migration invasion

Apogossypolone, a novel inhibitor of anfiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro

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Asian Journal of Andrology 2010年第5期12卷 697-708页

作者： xian-qing Zhang xiao-feng huang xing-Bin Hu Yong-Hua Zhan Qun-xing An shi-Ming Yang Ai-Jun xia Jing Yi Rui Chen shi-Jie Mu Dao-Cheng Wu Department of Blood Transfusion Xijing Hospital Fourth Military Medical University Xi ＇an 710032 China Central Laboratory School of Basic Medicine Fourth Military Medical University Xi ＇an 710032 China School of Life Sciences and Technology Xidian University Xi ＇an 710071 China Department of Blood Transfusion Tangdu Hospital Fourth Military Medical University Xi＇an 710038 China The Key Laboratory of Biomedical Information Engineering of the Ministry of Education Xi ＇an Jiaotong University Xi＇an 710038 China

Limited treatment options are available for aggressive prostate cancer. Gossypol has been reported to have a potent anticancer activity in many types of cancer. It can increase the sensitivity of cancer cells to alkylating agents, diminish multidrug resistance and decrease metastasis. Whether or not it can induce autophagy in cancer cells has not yet been determined. Here we investigated the antiproliferative activity of apogossypolone （ApoG2） and （-）-gossypol on the human prostate cancer cell line PC3 and LNCaP in vitro. Exposure of PC-3 and LNCaP cells to ApoG2 resulted in several specific features characteristic of autophagy, including the appearance of membranous vacuoles in the cytoplasm and formation of acidic vesicular organelles. Expression of autophagy-associated LC3-Ⅱ and beclin-1 increased in both cell lines after treatment. Inhibition of autophagy with 3-methyladenine promoted apoptosis of both cell types. Taken together, these data demonstrated that induction of autophagy could represent a defense mechanism against apoptosis in human prostate cancer cells.

关键词： apogossypolone apoptosis autophagy prostate cancer

Simulation of silicon strip detector for space-based cosmic ray experiments with Allpix^(2)

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Radiation Detection Technology and Methods 2023年第3期7卷 355-363页

作者： Lu Bai Hu Liu feng-Rong Zhu Zhi-Cheng Tang Rui qiao Yan-Jin Zheng Teng Li Qian-Qian shi xing-Tao huang Wen-Hao huang School of Physical Science and Technology Southwest Jiaotong UniversityNo.999Xi’an RoadChengdu 610031China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadBeijing 100049China Institute of Frontier and Interdisciplinary Science Shandong University72 Jimobinhai RoadQingdao 266237China

Purpose Silicon strip detectors are widely applied in space-based cosmic ray experiments and most of the silicon strip detectors deploy an analytical method for its ***,the analytical method simplifies the physical process of propagation of electrons/holes generated inside the silicon detector by particles that pass through the *** order to simulate silicon strip detectors with different configurations comprehensively,the Allpix^(2),an open-source software,is used to study those *** When particle passes through the silicon detector,energy is deposited based on Geant4 simulation,and electron-hole pairs are created due to the deposited *** Allpix^(2)simulation method and the analytical method are both used to calculate or simulate the diffusion and drift processes that electron-hole pairs propagate inside the silicon detector under internal electric field,and the number of electrons/holes accumulated at implanted strips are *** and conclusion The number of electrons/holes accumulated along the implanted strips are compared between the Allpix^(2)simulation method and analytical method for different incident angles and different incident positions,they are found to be in good agreement for proton particles,while there are discrepancies for carbon and silicon *** Allpix^(2)software may be an important tool for the study of response of silicon strip detectors in *** charge resolution of single implanted strip predicted by Allpix^(2)simulation method is about 4.7%for proton,3.8%for carbon and 1.6%for silicon particles for an incident angle of 45◦.

关键词： Silicon strip detector Simulation Analytical method Allpix^(2)

Three-dimensional Pattern Instability of a Soft Elastic Film under Van der Waals Forces

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Three-dimensional Pattern Instability of a Soft Elastic Film...

Crystal Structure of[Cd(pom)_2Cl_2]

2003年纳米和表面科学与技术全国会议

作者： xi-qiao feng, shi-qing huang, Qun-Yang Li and Shou-Wen Yu Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China

In recent years, soft condensed materials (e.g., polymers, biomacromolecules, colloids, membranes, Langmuir-Blodgett films and soft interfaces) have attracted a great deal of interest from physicists, chemists, biologists and materials scientists. Soft materials exhibit some anomalous behaviors, which include both structural and dynamical behaviors, such as density, surface instability and dewetting, glass transition temperature, diffusion coefficient, chain conformation and relaxation. Despite a growing literature in this area, it is obvious that a clear understanding of properties of soft materials has not yet been reached. And it is very

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Chinese Journal of Structural Chemistry 1996年第4期15卷 330-332页

作者： Wu Wen-shi(Department of Chemistry,Hua-qiao University, Fujian, China, 362011)Dong Mei-Bin Li Song-xian Zhang Han-Hui Cheng Jian-Zhong(Department of Chemistry, Fuzhou University, Fujian , 350002) huang You-qing Hu Seng-Zhi (Department of Chemtstry, xi 华侨大学化学系福建泉州福州大学化学系福建福州厦门大学化学系福建厦门

Catena-[bis (3-methyl-4-nitropyridine N-oxide ) cadmiumdichloride],[Cd(C_6H_6N_2O_3)_2Cl_2], M_r= 491. 56, monoclinic , P2_1, a= 3. 799 (3), b= 29. 231 ( 9),c=7. 679(5) A, β=100. 19(6)°, V=839. 4 A￣3, Z=2, D_c= 1. 94 g/cm￣3, λ(MoKa)= 0. 71069 A, F(000) =484, P(MoKa) = 16. 5 cm￣(-1), final R=0. 038 for 1202 Observed reflections, T= 296K. The Cd atom is octahedrally coordinated by two O atoms from the trans 3-methyl-4-nitropyridine N-oxide (pom) ligands in the axial positions and four Cl atoms lying in the equatorial plane. The coordination octahedra form chains along the short a axis by edge sharing through the Cl atoms.

关键词： cadmium complex nonlinear optical material one-dimensional coordination crystal structure

Implantation-decay method to study the β-delayed charged particle decay

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Nuclear Science and Techniques 2018年第7期29卷 145-151页

作者： Yu-Ting Wang De-qing Fang xin-xing Xu Li-Jie Sun Kang Wang Peng-Fei Bao Zhen Bai xi-Guang Cao Zhi-Tao Dai Bing Ding Wan-Bing He Mei-Rong huang shi-Lun Jin Cheng-Jian Lin Ming Lu Long-xiang Liu Yong Li Peng Ma Jun-Bing Ma Jian-Song Wang shi-Tao Wang Shao-Qiang Ye Yan-Yun Yang Cheng-Long Zhou Ming-Hui Zhao Huan-qiao Zhang Yu-Gang Ma Wen-qing Shen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of the Chinese Academy of Sciences Beijing 100049China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201203China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

In this paper,the implantation-decay method is introduced to study the β-delayed charged particle decay.A silicon detector array was used for the implantation of the incident beams and for the detection of the emitted *** experimental measurement on the β-delayed particle emission from ^(22)Al was used to demonstrate the *** half-life value,charged particle spectroscopy,γ ray spectrum,and γ particle coincidence for the decay process were obtained and compared with previous experimental results for ^(22)*** results show that the implantation-decay method,using a silicon detector array,is a suitable experimental method to study the β-delayed charged particle decay for proton-rich nuclei.

关键词：腐烂粒子培植学习试验性光谱学半衰期原子核

The energy response of LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals for GECAM

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Nuclear Science and Techniques 2024年第2期35卷 110-122页

作者： Pei-Yi feng xi-Lei Sun Zheng-Hua An Yong Deng Cheng-Er Wang huang Jiang Jun-Jie Li Da-Li Zhang xin-qiao Li Shao-Lin xiong Chao Zheng Ke Gong Sheng Yang xiao-Jing Liu Min Gao xiang-Yang Wen Ya-qing liu Yan-Bing Xu xiao-Yun Zhao Jia-Cong Liu Fan Zhang Hong Lu Particle and Astrophysics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Experimental Physics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of South ChinaHengyang 421001China National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.and General Research Institute for Nonferrous MetalsBeijing 100088China

The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic *** nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton *** the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 *** NaI(Tl)crystal demonstrated an"excess"light output in the 6-200 keV range,reaching a maximum"excess"of 9.2%at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma ***,we explored the underlying causes of the observed nonlinearity in these *** study not only elucidates the detector responses of GECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.

关键词： LaBr_(3)(Ce)detector LaBr_(3)(Ce,Sr)detector NaI(Tl)detector GECAM Energy response Light yield nonlinearity