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Photonics Research 2020年第10期8卷 1558-1565页

作者： JUN MA YANG HE xue BAI LI-PENG SUN KA CHEN KYUNGHWAN OH BAI-ou GUAN Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics TechnologyJinan UniversityGuangzhou 511443China Photonic Device Physics Laboratory Department of PhysicsYonsei UniversitySeoul 033722South Korea

Interaction of acoustic waves and microbubbles occurs in numerous biomedical applications including ultrasound imaging,drug delivery,lithotripsy treatment,and cell manipulation,wherein the acoustically driven microbub-blcs routincly act as active microscale oscillators or actuators.In contrast,microbubbles were utilized here as passive reccivers to detect broadband ultrasound waves in aqueous environments.The microbubble was photo-thermally generated on a microstructured optical fiber(MOF)tip,forming a flexible Fabry-Perot cavity whose gas-water interface was sensitive to ultrasound waves.The MOF severed as both a low-loss waveguide and a compact light condenser,allowing high-efficiency generation and stabilization of ultrasmall microbubbles.Integrated with all-fiber interferometry,a 10 um diameter microbubble exhibited a low noise-cquivalcnt pressur elevei of^3.4 mPa/Hz^1/2 and a broad bandwidth of^0.8 MHz,capable of detecting weak ultrasounds emittedfrom red blood cells irradiated by pulsed laser light.With advantages of high sensitivity,compact size,and low cost,the microbubble-based ultrasound sensor has great potential in biomedical imaging and sensing applications.

关键词： microstructure bubble cavity

Intact Canal Wall Mastoidectomy Combined with Balloon Dilation Eustachian Tuboplasty in the Treatment of Middle Ear Cholesterol Granuloma

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Chinese Medical Journal 2018年第6期131卷 741-742页

作者： Yong-Kang ou xue-Yuan Zhang Yao-Dong Xu Hao Xiong Mao-Jin Liang Department of Otolaryngology Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou Guangdong 510120 China Institute of Hearing and Speech-Language Science Sun Yat-Sen University Guangzhou Guangdong 510120 China

To the Editor： Cholesterol granuloma （CG） refers to granulation tissue containing cholesterol crystals and giant cells and is a tbreign body response elicited by local tissues. The pathogenesis of middle ear CG can be explained using the classic obstruction-vacuum theory caused by negative middle ear pressure, The Eustachian tube （ET） plays a decisive role in influencing the gas exchange and maintaining the ventilation and pressure of the middle ear. The traditional treatment is mastoidectomy, routinely combined with middle ear ventilation tube insertion or tube insertion during re-examination after operation. Eustachian tuboplasty by balloon dilation can improve the pathological state of ET via specific mechanisms to achieve functional recovery and satisfactory clinical efficacy.

关键词： DILATATION TUBE

Synthesis and characterization of macrocyclic compounds with a hydroxyl functional group

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Chinese Chemical Letters 2013年第10期24卷 869-872页

作者： Min ou Chun Zhu Qi-Long Zhang Bi-xue Zhu Key Laboratory of Macrocyclic and Supramolecular Chemistry Guizhou University Department of Chemistry Guiyang Medical College

A novel [1＋1] Schiff-base macrocyclic compound 3 has been synthesized from precursor 1, 1,3-bis（2＇- formylphenoxy）-2-propanol, and precursor 2, resorcinol-bis（4-aminophenyl）ether, via condensation and cyclizaction using Ba2＋ as template. The macrocycle 3 was further reduced giving saturated macrocycle 4. The structures of 3 and 4 were characterized by elemental analysis, ~H NMR, IR, and MS spectra, and their structures were determined via single crystal X-ray diffraction studies. X-ray diffraction analysis revealed that the macrocyclic compound 3 has a folded conformation, and the corresponding reduced product 4 adopts a twisted and folded conformation due to its flexible nature. ~ 2013 Bi-xue Zhu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Schiff base Macrocyclic compound Synthesis Structure

多源流理论视域下高等教育高质量发展政策变迁与路径选择

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黑龙江高教研究 2023年第7期41卷 12-17页

作者：欧李梅廖春华西南财经大学四川成都611130 四川大学四川成都610065

“建设高质量教育体系”是我国“十四五”时期的政策导向和重点要求。以多源流理论分析我国高等教育发展政策转型过程,是对政策决策的模糊性作出模型化努力,也是对政策变迁动力机制的一种解释。基于多源流分析框架发现:高等教育与经济... 详细信息

“建设高质量教育体系”是我国“十四五”时期的政策导向和重点要求。以多源流理论分析我国高等教育发展政策转型过程,是对政策决策的模糊性作出模型化努力,也是对政策变迁动力机制的一种解释。基于多源流分析框架发现:高等教育与经济社会发展需求的矛盾,通过教育统计数据、系列焦点事件、社会各界反思反馈,形成问题源流;党和政府的顶层设计、相关共同体的政策构想、师生家长群的体验诉求,构成政策源流;公众情绪、意识形态转化为政治源流。问题源流、政策源流、政治源流交互耦合,合力推动了我国高等教育高质量发展的政策转型。新发展阶段,我国高等教育的“精准研策”应更注重系统性、整体性、协同性,在循序渐进中推动政策迭代趋优。

关键词：多源流理论高等教育高质量发展政策转型

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“四联合”护理德育工作的效果研究

中华护理教育 2018年第2期15卷 112-115页

作者：章雪玲黄美凌陈云欧家红李雪丽广州医科大学附属第三医院广州市510150

目的探讨"四联合"护理德育工作提高护理实习生护理道德水平的效果。方法教学医院护理学教研室、团委、工会、宣传部构建"四联合"护理德育团队,对2016年—2017年在该院实习的100名护理专业学生开展护理德育工作。比较2016年—2017年和201... 详细信息

目的探讨"四联合"护理德育工作提高护理实习生护理道德水平的效果。方法教学医院护理学教研室、团委、工会、宣传部构建"四联合"护理德育团队,对2016年—2017年在该院实习的100名护理专业学生开展护理德育工作。比较2016年—2017年和2015年—2016年实习生的护理道德测评得分。结果 2016年—2017年护理实习生的护理道德认知、护理道德信念、护理道德情感、护理道德意志、护理道德行为得分高于2015年—2016年的学生(P<0.05)。结论 "四联合"护理德育工作有助于提高护理实习生的护理道德水平。

关键词：临床实习伦理学护理教育护理

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艾滋病合并中枢性马尔尼菲篮状菌病临床特征

中国感染控制杂志 2023年第6期22卷 674-679页

作者：卢焕黎彦君秦英梅黄金萍欧汝志李雪琴林健燕南宁市第四人民医院感染性疾病科广西艾滋病临床治疗中心(南宁) 广西南宁530023 南宁市第四人民医院医院办公室广西南宁530023

目的分析艾滋病合并中枢性马尔尼菲篮状菌病患者的临床特点,提高临床早期诊断水平。方法回顾性分析2014—2020年南宁市第四人民医院收治的5例经脑脊液培养确诊马尔尼菲篮状菌感染的艾滋病患者的临床资料。结果5例艾滋病合并中枢性马尔... 详细信息

目的分析艾滋病合并中枢性马尔尼菲篮状菌病患者的临床特点,提高临床早期诊断水平。方法回顾性分析2014—2020年南宁市第四人民医院收治的5例经脑脊液培养确诊马尔尼菲篮状菌感染的艾滋病患者的临床资料。结果5例艾滋病合并中枢性马尔尼菲蓝状菌感染者中男性4例,平均年龄35.2岁。脑脊液检出马尔尼菲篮状菌平均时间8 d。脑脊液改变主要表现为白细胞计数和蛋白质升高,葡萄糖和氯化物降低。头颅影像检查主要表现为颅内感染灶。5例患者结局均死亡,其中2例误诊为中枢性结核分枝杆菌感染,2例病情危重入院不足1周死亡,1例经过有效抗真菌治疗但最终因感染性休克死亡。3例既往接受过规范抗人类免疫缺陷病毒(HIV)治疗。结论艾滋病合并中枢性马尔尼菲篮状菌病临床表现缺乏特异性,早期诊断困难,临床易误诊、漏诊,病死率高,临床应高度重视。

关键词：马尔尼菲篮状菌艾滋病中枢神经系统感染临床特征

Adsorption of tetrodotoxin by flexible shape-memory polymers synthesized from silica-stabilized Pickering high internal phase emulsion

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第10期22卷 805-818页

作者： Hong-xiang ou Chen-xia GONG Hong-lai xue Dong-sheng ZHou Kai-jia LI Shu-cheng LIU School of Environmental and Safety Engineering Changzhou UniversityChangzhou 213164China Institute of Public Safety and Emergency Management Changzhou UniversityChangzhou 213164China School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China

Flexible shape-memory polymers were synthesized by Pickering high internal phase emulsion(HIPE)polymerization and used to adsorb and separate tetrodotoxin(TTX)from an aqueous solution.SiO_(2)nanoparticles were used to stabilize the Pickering oil-in-water(O/W)HIPEs.We introduced imidazolium-modified bromobutyl rubber(IBR)with excellent mechanical properties and high viscosity into the emulsion system as the shape-memory monomer.The properties,such as shape memory and morphology,were characterized by various methods,and batches of static adsorption experiments were conducted to analyze the adsorption performance of SiO_(2)@IBR on TTX.The characterization revealed that the SiO_(2)@IBR had a porous structure and good shape memory.Thus,the combination of SiO_(2)particles and IBR prevented shedding of SiO_(2)and enhanced the mechanical and adsorption properties of SiO_(2)@IBR.The results of the adsorption experiments indicated that the SiO_(2)@IBR had good adsorption of TTX.Both the Langmuir and Freundlich models fitted the isothermal adsorption experiment process.The TTX adsorption capacity of SiO_(2)@IBR was about 290.44 mg/g at 308 K.The fitting results of the pseudo-first-order and pseudosecond-order kinetic models showed that the adsorption process involved both chemical bonding and physical adsorption.After 10 adsorption and desorption experiments,the adsorption capacity of SiO_(2)@IBR decreased less than 0.03%,indicating that it had good adsorption and regeneration performance.

关键词： Tetrodotoxin(TTX) SiO_(2) Imidazolium-modified bromobutyl rubber(IBR) Pickering high internal phase emulsion(HIPE) Adsorption

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粗纺绒线双面机绣产品的开发

毛纺科技 2015年第4期43卷 6-10页

作者：龚雪鸥清华大学美术学院北京100084

研究了运用新型水溶性纤维对粗纺羊绒纱线进行处理的多种方法,以及如何改进绒线强度、捻度、纱支等以满足机绣用纱的要求。使用60 Nm羊绒和水溶性纤维按45∶55质量比混纺的纱线,同时解决了机绣设备硬件配置和打版设计等技术难题,在田岛... 详细信息

研究了运用新型水溶性纤维对粗纺羊绒纱线进行处理的多种方法,以及如何改进绒线强度、捻度、纱支等以满足机绣用纱的要求。使用60 Nm羊绒和水溶性纤维按45∶55质量比混纺的纱线,同时解决了机绣设备硬件配置和打版设计等技术难题,在田岛多功能刺绣机TMLHⅡ-902型设备上开发出具有独特质感和外观效果的粗纺绒线双面机绣产品,开辟了粗纺绒线在纺织行业中的新应用,为绒线机绣产品创新提供了新的技术支撑点,为羊绒产品生产企业提供了借鉴。

关键词：粗纺羊绒纱线水溶性纤维双面机绣产品开发

Relation Between Cellular Senescence and Liver Diseases

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Chinese Medical Sciences Journal 2016年第2期31卷 121-126页

作者： Guo-wen Li xue-feng Yang Nian Fu Yan ou-yang Kai Qing Department of Gastroenterology the Affiliated Nanhua Hospital of University of South China

Cellular senescence refers to a process that cellular proliferation and differentiation modulated by the multiple stimulating factors gradually decline. Aging cells present the irreversible stop of proliferation and differentiation and change in secretory function because the cell cycle of aging cells is steadily blocked at some point. It has have been shown that cellular senescence plays an important role in the occurrence and development of liver diseases. In this paper, we review the advances in relations between cellular senescence and liver diseases.

关键词： cellular senescence mechanism liver diseases liver fibrosis liver cancer

Role of exosomal long non-coding RNAs in colorectal cancer

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 867-878页

作者： Ru Sun Xiao-Yun He Cheng mei Chun-Lin ou Department of Blood Transfusion Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Blood Transfusion Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Exosomes are a class of small extracellular vesicles,30-150 nm in diameter,that transfer biological information(e.g.,DNA,RNA,and protein)via cell-to-cell communication.Exosomes play critical roles in the occurrence and development of human cancers,including colorectal cancer(CRC).Recent studies have shown that long non-coding RNAs(lncRNAs)can be encapsulated in exosomes,which transfer lncRNAs from secretory cells into recipient cells.This process affects the progression of CRC,since exosomal lncRNAs display special and extensive functions in CRC tumorigenesis,including malignant proliferation,metastasis,chemoresistance,and inflammatory response.Moreover,due to their specificity and sensitivity,exosomal lncRNAs are released into body fluids(e.g.,urine,sputum,and plasma),which have the potential to be biomarkers of CRC tumorigenesis within screening efforts and medical and epidemiologic research.In this review,we aim to clarify the function and mechanism of exosomal lncRNAs in CRC tumorigenesis and provide a strategy for early diagnosis and medical treatment of this malignancy.

关键词： Exosomes Long non-coding RNAs Colorectal cancer Chemoresistance Inflammatory response Therapy