Role of exosomal long non-coding RNAs in colorectal cancer
作者机构：Department of Blood TransfusionAffiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of PathologyXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Blood TransfusionXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第8期
页 面：867-878页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Natural Science Foundation of China,No.81903032 China Postdoctoral Science Foundation,No.2020M672520 Research Program of Hunan Health Commission,China,No.202103030659 Youth Fund of Xiangya Hospital,No.2018Q011.
主 题：Exosomes Long non-coding RNAs Colorectal cancer Chemoresistance Inflammatory response Therapy
摘 要：Exosomes are a class of small extracellular vesicles,30-150 nm in diameter,that transfer biological information(e.g.,DNA,RNA,and protein)via cell-to-cell communication.Exosomes play critical roles in the occurrence and development of human cancers,including colorectal cancer(CRC).Recent studies have shown that long non-coding RNAs(lncRNAs)can be encapsulated in exosomes,which transfer lncRNAs from secretory cells into recipient cells.This process affects the progression of CRC,since exosomal lncRNAs display special and extensive functions in CRC tumorigenesis,including malignant proliferation,metastasis,chemoresistance,and inflammatory response.Moreover,due to their specificity and sensitivity,exosomal lncRNAs are released into body fluids(e.g.,urine,sputum,and plasma),which have the potential to be biomarkers of CRC tumorigenesis within screening efforts and medical and epidemiologic research.In this review,we aim to clarify the function and mechanism of exosomal lncRNAs in CRC tumorigenesis and provide a strategy for early diagnosis and medical treatment of this malignancy.
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