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The Influence of Culture and Biographical Variables on the Brand Image of Google and Baidu: An Exploratory Study in Guangzhou,China

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中国市场 2014年第9期 8-20页

作者： Rayne Cyla Handley nicholas james Raw Mattheus Louw Lynette Louw 罗德斯大学

The study found significant correlations between the culture dimensions of Confucian work dynamism,humanheartedness and moral discipline and the brand image dimensions of online search *** was also found that several significant relationships exist between the biographical variables of age and education and the brand image dimensions,and that culture and biographical variables have a linear relationship with brand *** findings highlight that culture and biographical information can influence Chinese consumer perceptions of an international or local *** thus need to align their brands with the culture and biographical profile of their target markets.

关键词： Cross - cultural management brand image China

Phagocytosed Polyhedrin-Cytokine Cocrystal Nanoparticles Provide Sustained Secretion of Bioactive Cytokines from Macrophages

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BioDesign Research 2021年第1期2021卷 47-58页

作者： Astrid Wendler nicholas james Michael H.Jones Christian Pernstich Cell Guidance Systems Ltd. Maia BuildingBabraham Research CampusCambridge CB223ATUK

Many cells possess the ability to engulf and incorporate particles by *** active process is characteristic of microorganisms as well as higher order *** mammals,monocytes,macrophages,and microglia are among the so-called professional *** addition,cells such as fibroblast and chondrocytes are classified as nonprofessional *** phagocytes play important roles in both the innate and adaptive immune responses,wound healing,and tissue ***,these cells are increasingly studied as targets and vectors of therapeutic intervention to treat a range of *** phagocytes are notoriously difficult to transfect limiting their study and ***,efforts have shifted towards the development of nanoparticles to deliver a cargo to phagocytic cells via ***,this approach carries significant technical challenges,particularly for protein *** have focused on the development of nanoscale cocrystalline protein depots,known as PODS®,that contain protein cargos,including ***,we show that PODS are readily phagocytosed by nonprofessional as well as professional phagocytic cells and have attributes,such as highly sustained release of cargo,that suggest potential utility for the study and exploitation of phagocytic cells for drug *** and macrophages that ingest PODS retain normal characteristics including a robust chemotactic ***,the PODS-cytokine cargo is secreted by the loaded cell at a level sufficient to modulate the behavior of surrounding nonphagocytic *** results presented here demonstrate the potential of PODS nanoparticles as a novel molecular tool for the study and manipulation of phagocytic cells and for the development of Trojan horse immunotherapy strategies to treat cancer and other diseases.

关键词： sustained healing professional

Optimization of operational strategies for rich gas enhanced oil recovery based on a pilot test in the Bakken tight oil reservoir

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Petroleum Science 2023年第5期20卷 2921-2938页

作者： Xincheng Wan Lu Jin nicholas A.Azzolina Jin Zhao Xue Yu Steven A.Smith james A.Sorensen Energy&Environmental Research Center University of North Dakota15 North 23rd StreetStop 9018Grand ForksND58202-9018USA

Horizontal well drilling and multistage hydraulic fracturing have been demonstrated as effective approaches for stimulating oil production in the Bakken tight oil ***,after multiple years of production,primary oil recovery in the Bakken is generally less than 10%of the estimated original oil in *** huff‘n’puff(HnP)has been tested in the Bakken Formation as an enhanced oil recovery(EOR)method;however,most field pilot test results showed no significant incremental oil *** of the factors affecting HnP EOR performance is premature gas breakthrough,which is one of the most critical issues observed in the field because of the presence of interwell ***,injected gas rapidly reaches adjacent production wells without contacting reservoir rock and increasing oil *** conformance control is therefore needed to avoid early gas breakthrough and improve EOR *** this study,a rich gas EOR pilot in the Bakken was carefully analyzed to collect the essential reservoir and operational data.A simulation model with 16 wells was then developed to reproduce the production history and predict the EOR performance with and without conformance *** operational strategies,including single-and multiple-well HnP,with different gas injection constraints were *** simulation results of single-well HnP without conformance control showed that a rich gas injection rate of at least 10 MMscfd was needed to yield meaningful incremental oil *** strategy of conformance control via water injection could significantly improve oil production in the HnP well,but injecting an excessive amount of water also leads to water breakthrough and loss of oil production in the offset *** analyzing the production performance of the wells individually,the arrangement of wells was optimized for multiple-well HnP *** multiwell results showed that rich gas EOR could improve oil production up to 7.4%by employing confor

关键词： Rich gas injection Bakken tight oil reservoir EOR strategies Conformance control Embedded discrete fracture model

A polarizing situation： Taking an in-plane perspective for next-generation near-field studies

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Frontiers of physics 2016年第2期11卷 1-17页

作者： P. james Schuck Wel Bao nicholas J. Borys Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Department of Materials Science and Engineering University of California Berkeley CA 94720-1760 USA

By enabling the probing of light-matter interactions at the functionally relevant length scales of most materials, near-field optical imaging and spectroscopy accesses information that is unobtainable with other methods. The advent of apertureless techniques, which exploit the ultralocalized and enhanced near-fields created by sharp metallic tips or plasmonic nanoparticles, has resulted in rapid adoption of near-field approaches for studying novel materials and phenomena, with spatial resolution approaching sub-molecular levels. However, these approaches are generally limited by the dominant out-of-plane polarization response of apertureless tips, restricting the exploration and discovery of many material properties. This has led to recent design and fabrication breakthroughs in near-field tips engineered specifically for enhancing in-plane interactions with near-field light components. This mini-review provides a perspective on recent progress and emerging directions aimed at utilizing and controlling in-plane optical polarization, highlighting key application spaces where in-plane near-field tip responses have enabled recent advancements in the understanding and development of new nanostructured materials and devices.

关键词： near-field optical microscopy nano-optics TERS plasmonics optical antenna 2D materials

Number of COVID-19 cases required in a population to detect SARS-CoV-2 RNA in wastewater in the province of Alberta, Canada:Sensitivity assessment

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Journal of Environmental Sciences 2023年第3期125卷 843-850页

作者： Qiaozhi Li Bonita E.Lee Tiejun Gao Yuanyuan Qiu Erik Ellehoj Jiaao Yu Mathew Diggle Graham Tipples Rasha Maal-Bared Deena Hinshaw Christopher Sikora nicholas J.Ashbolt james Talbot Steve E.Hrudey Xiaoli Pang School of Public Health University of AlbertaEdmontonAB T6G 2R3Canada Department of Pediatrics University of AlbertaEdmontonAB T6G 1C9Canada Department of Laboratory Medicine and Pathology University of AlbertaEdmontonAB T6G 2B7Canada University of Alberta Central Receiving EdmontonAlbertaT6G 2R3Canada Provincial Laboratory for Public Health EdmontonAlbertaCanada EPCOR EdmontonAB T5H 0E8Canada Department of Medicine University of AlbertaEdmontonAB T6G 2G3Canada Faculty of Science and Engineering Southern Cross UniversityEast Lismore NSW 2480Australia

With a unique and large size of testing results of 1,842 samples collected from 12 wastewater treatment plants (WWTP) for 14 months through from low to high prevalence of COVID-19,the sensitivity of RT-qPCR detection of SARS-CoV-2 RNA in wastewater that correspond to the communities was computed by using Probit *** study determined the number of new COVID-19 cases per 100,000 population required to detect SARS-CoV-2RNA in wastewater at defined probabilities and provided an evidence-based framework of wastewater-based epidemiology surveillance (WBE).Input data were positive and negative test results of SARS-CoV-2 RNA in wastewater samples and the corresponding new COVID-19 case rates per 100,000 population served by each *** analyses determined that RT-qPCR-based SARS-CoV-2 RNA detection threshold at 50%,80%and 99%probability required a median of 8 (range:4-19),18 (9-43),and 38 (17-97) of new COVID-19 cases/100,000,***,the positive detection rate at 50%,80%and 99%probability were 0.01%,0.02%,and 0.04%averagely for new cases in the *** study improves understanding of the performance of WBE SARS-CoV-2 RNA detection using the large datasets and prolonged study *** COVID-19 burden at a community level that would result in a positive detection of SARS-CoV-2 in wastewater is critical to support WBE application as a supplementary warning/monitoring system for COVID-19 prevention and control.

关键词： SARS-CoV-2 COVID-19 cases Wastewater Probit analysis Probability Detection sensitivity

Combined risk modelling approach to identify the optimal carotid revascularisation approach

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Stroke & Vascular Neurology 2021年第3期6卷 476-482,I0080-I0084页

作者： james Francis Burke Lewis B Morgenstern nicholas H Osborne Rodney A Hayward Neurology University of Michigan Michigan MedicineAnn ArborMichiganUSA Vascular Surgery Univerity of Michigan MedicineAnn ArborMichiganUSA Internal Medicine University of Michigan Michigan MedicineAnn ArborMichiganUSA

Background Carotid endarterectomy(CEA)results in fewer perioperative strokes,but more myocardial infarctions(MI)than carotid artery stenting(CAS).We explored a combined modelling approach that stratifies patients by baseline stroke and *** Baseline registry-based risk models for perioperative stroke and MI were identified via literature *** then selected treatment risk models in the Carotid Revascularisation Stenting versus Endarterectomy(CREST)trial by serially adding covariates(baseline risk,treatment(CEA vs CAS),treatment-risk interaction and age-treatment interaction terms).Treatment risk models were externally validated using data from the Society for Vascular Surgery(SVS)Vascular Quality Initiative(VQI)CEA and carotid stenting registries and treatment models were recalibrated to the SVS-VQI *** net benefit was estimated by summing the predicted stroke and MI risk differences with CEA versus *** Perioperative treatment models had moderate predictiveness(c-statistic 0.69 for stroke and 0.68 for MI)and reasonable calibration across the risk spectrum for both stroke and MI within *** external validation in SVS-VQI,predictiveness was substantially reduced(c-statistic 0.61 for stroke and 0.54 for MI)and models substantially overpredicted *** patients(86.7%)were predicted to have net benefit from CEA in CREST(97.0%of symptomatic patients vs 75%of asymptomatic patients).Discussion A combined modelling approach that separates risk elements has potential to inform optimal ***,our current approach is not ready for clinical *** data support guidelines that suggest that CEA should be the preferred revascularisation modality in most patients with symptomatic carotid stenosis.

关键词： carotid Surgery optimal

Diversity of Insect Flower Visitors on Macadamia within a Monoculture Orchard in Murang’a County, Central Kenya

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Advances in Entomology 2023年第4期11卷 239-255页

作者： nicholas I. Njue james W. Muthomi George N. Chemining’wa John H. Nderitu Josiah Achieng james J. Odanga Department of Plant Science and Crop Protection University of Nairobi Nairobi Kenya Invertebrate Zoology Section National Museums of Kenya Nairobi Kenya

Macadamia is cultivated for its nutritious edible kernel. In Kenya, the crop is predominantly grown by smallholder farmers mainly for export markets. Macadamia trees also enhance agro-forestry conservation, in the East African farmlands, by providing habitat and floral resources to beneficial arthropods such as insect pollinators. Allogamy of macadamia flowers is largely dependent on insects that pollinate and consequently influence the nut set, retention and yield. However, there is limited information on macadamia insect flower visitors in Kenya. This article assessed the diversity of insects that forage flowers of macadamia crop, and further evaluated their temporal distribution, in Murang’a county, central Kenya. Insect flower visitors were sampled weekly using a butterfly net for twelve consecutive months, from January 2021 to December 2021. Sixty-one insect species were recorded foraging macadamia flowers in Murang’a county, central Kenya. There was a statistical difference in the Simpson diversity index among weather seasons, dry, long rain, cold and short rain (p Apis mellifera), a key pollinator species, being the most abundant flower visitor. This study provides strong baseline information, to scientists and farmers, on probable macadamia pollinator species, in central Kenya. .

关键词： Macadamia Flowers Insect Diversity Kenya

Hemobilia: Etiology, diagnosis, and treatment

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Liver Research 2018年第4期2卷 200-208页

作者： Rani Berry james Han Ani A.Kardashian nicholas F.LaRusso james H.Tabibian Department of Internal Medicine UCLA Ronald Reagan Medical CenterLos AngelesCAUSA Department of Internal Medicine University of California IrvineIrvineCAUSA UCLA Gastroenterology Fellowship Training Program Vatche and Tamar ManoukianDivision of Digestive DiseasesLos AngelesCAUSA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA Division of Gastroenterology Department of MedicineOlive View-UCLA Medical CenterSylmarCAUSA

Hemobilia refers to bleeding from and/or into the biliary tract and is an uncommon but important cause of gastrointestinal *** of hemobilia date back to the 1600s,but due to its relative rarity and challenges in diagnosis,only in recent decades has hemobilia been more critically *** majority of cases of hemobilia are iatrogenic and caused by invasive procedures involving the liver,pancreas,bile ducts and/or the hepatopancreatobiliary vasculature,with trauma and malignancy rep-resenting the two other leading causes.A classic triad of right upper quadrant pain,jaundice,and overt upper gastrointestinal bleeding has been described(***'s triad),but this is present in only 25%e30%of patients with ***,prompt diagnosis depends critically on having a high index of suspicion,which may be based on a patient's clinical presentation and having recently undergone(peri-)biliary instrumentation or other predisposing *** treatment of hemobilia depends on its severity and suspected source and ranges from supportive care to advanced endoscopic,interventional radiologic,or surgical *** we provide a clinical overview and update regarding the eti-ology,diagnosis,and treatment of hemobilia geared for specialists and subspecialists alike.

关键词： Hemobilia Upper gastrointestinal hemmorhage Etiology Diagnosis Imaging Hepatopancreatobiliary interventions

Nonlinear Model of Mean Free Surface of Waves

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China Ocean Engineering 1999年第2期14卷 155-162页

作者： nicholas DODD Ph. D. Coastal Group HR Wallingford Howbery Park Wallingford

A nonlinear model of mean free surface of waves or wave set-up is presented. The model is based on that of Roelvink (1993), but the numerical techniques used in the solution are based on the Weighted-Average Flux (WAF) method (Watson el al., 1992), with Time-Operator-Splitting (TOS) used for the treatment of the source terms. This method allows a small number of computational points to be used, and is particularly efficient in modeling wave set-up. The short wave (or primary wave) energy equation is solved by use of a more traditional Lax-Wendroff technique. A nonlinear wave theory (james, 1974) is introduced. The model described in this paper is found to be satisfactory in most respects when compared with the measurements conducted by Stive (1983) except in modeling the mean free surface very close to the mean shoreline.

关键词： mean free surface radiation stress hyperbolic wave theory nonlinear model wave propagation