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Grappling with COVID-19 by imposing and lifting nonpharmaceutical interventions in Sri Lanka: A modeling perspective

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Infectious Disease Modelling 2021年第1期6卷 820-831页

作者： mahesh jayaweera Chamath Dannangoda Dilum Dilshan Janith Dissanayake Hasini Perera Jagath Manatunge Buddhika Gunawardana Department of Civil Engineering University of MoratuwaSri Lanka Department of Physics and Astronomy University of Texas at Rio Grande ValleyBrownsvilleTX78520USA Department of Civil&Environmental Engineering College of EngineeringSeoul National University1Gwanak-roGwanak-guSeoul08826Republic of Korea Department of Forestry and Environmental Science University of Sri JayewardenepuraSri Lanka

The imposition and lifting of non-pharmaceutical interventions(NPIs)to avert the COVID-19 pandemic have gained popularity worldwide and will continue to be enforced until herd immunity is *** developed a linear regression model to ascertain the nexus between the time-varying reproduction number averaged over a time window of six days(R_(ts))and seven NPIs:contact tracing,quarantine efforts,social distancing and health checks,hand hygiene,wearing of facemasks,lockdown and isolation,and health-related *** analysis suggests that the second wave that emerged in Sri Lanka in early October 2020 continued despite numerous *** model indicates that the most effective single NPI was lockdown and ***,the least effective individual NPIs were hand hygiene and wearing of *** model also demonstrates that to mitigate the second wave to a satisfactory level(R_(ts)<1),the best single NPI was the contact tracing with stringent imposition(%of improvement of R_(ts) was 69.43 against the base case).By contrast,the best combination of two NPIs was the lockdown&isolation with health-related supports(%of improvement was 31.92 against the base case).As such,many health authorities worldwide can use this model to successfully strategize the imposition and lifting of NPIs for averting the COVID-19 pandemic.

关键词： Contact tracing Isolation Lockdown Modeling Reproduction number

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Role of intravascular ultrasound and optical coherence tomography in intracoronary imaging for coronary artery disease:a systematic review

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Journal of Geriatric Cardiology 2024年第1期21卷 104-129页

作者： Maruf Sarwar Stephen Adedokun mahesh Anantha Narayanan Department of Cardiovascular Sciences White River HealthBatesvilleARUSA Division of Cardiology University of Tennessee at MemphisTNUSA University of Arkansas Medical Sciences Little RockARUSA

Coronary angiography has long been the standard for coronary imaging,but it has limitations in assessing vessel wall anatomy and guiding percutaneous coronary intervention(PCI).Intracoronary imaging techniques like intravascular ultrasound(IVUS)and optical coherence tomography(OCT)can overcome these *** uses ultrasound and OCT uses near-infrared light to visualize coronary pathology in unique ways due to differences in temporal and spatial *** techniques have evolved to offer clinical utility in plaque characterization and vessel assessment during ***-analyses and adjusted observational studies suggest that both IVUS and OCT-guided PCI correlate with reduced cardiovascular risks compared to angiographic guidance *** IVUS demonstrates consistent clinical outcome benefits,OCT evidence is less *** has progressed from early motion detection to high-resolution systems,with smaller compatible *** utilizes near infrared light to achieve unparalleled resolutions,but requires temporary blood clearance for optimal *** visualization and guidance make IVUS and OCT well-suited for higher risk PCI in patients with diabetes and chronic kidney disease by allowing detailed visualization of complex lesions and ensuring optimal stent deployment and positioning in PCI for patients with type 2 diabetes and chronic kidney disease,improving *** and recent advancements in zero-and low-contrast OCT techniques can reduce nephrotoxic contrast exposure,thus helping to minimize PCI complications in these high-risk patient *** and OCT provide valuable insights into coronary pathophysiology and guide interventions precisely compared to angiography *** have comparable clinical outcomes,emphasizing the need for tailored imaging choices based on clinical *** refinement and integration of intravascular imaging will likely play a pivotal role in optimizing coronary interventions and outcomes.

关键词： coronary anatomy limitations

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Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation:Evaluating susceptibility to the development of obesity and NAFLD

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Genes & Diseases 2024年第3期11卷 34-38页

作者： MJ mahesh Kumar Shailendra Arindkar Masum Saini Perumal Nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and Molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

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Enhancing Software Effort Estimation:A Hybrid Model Combining LSTM and Random Forest

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Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 42-51页

作者： Badana mahesh Mandava Kranthi Kiran Department of Computer Science and Engineering GITAM Deemed to be UniversityVishakhapatnam 561203India Department of Computer Science and Engineering Anil Neerukonda Institute of Technology&SciencesVishakhapatnam 531162India

Effort estimation plays a crucial role in software development projects,aiding in resource allocation,project planning,and risk *** estimation techniques often struggle to provide accurate estimates due to the complex nature of software *** recent years,machine learning approaches have shown promise in improving the accuracy of effort estimation *** study proposes a hybrid model that combines Long Short-Term Memory(LSTM)and Random Forest(RF)algorithms to enhance software effort *** proposed hybrid model takes advantage of the strengths of both LSTM and RF *** evaluate the performance of the hybrid model,an extensive set of software development projects is used as the experimental *** experimental results demonstrate that the proposed hybrid model outperforms traditional estimation techniques in terms of accuracy and *** integration of LSTM and RF enables the model to efficiently capture temporal dependencies and non-linear interactions in the software development *** hybrid model enhances estimation accuracy,enabling project managers and stakeholders to make more precise predictions of effort needed for upcoming software projects.

关键词： software effort estimation hybrid model ensemble learning LSTM temporal dependencies non⁃linear relationships

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Techno-Economic Optimization of Novel Stand-Alone Renewable Based Electric Vehicle Charging Station near Bahria Town Karachi,Sindh Pakistan

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Energy Engineering 2024年第6期121卷 1439-1457页

作者： Aneel Kumar mahesh Kumar Amir Mahmood Soomro Laveet Kumar Department of Electrical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan Department of Mechanical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan

Electric vehicles (EVs) are the most interesting and innovative technology in the 21st century because of theirenormous advantages, both technically and economically. Their emissions rate compared to fuel-based vehicles isnegligible as they do not consume fuel and hence do not emit any harmful gases. However, their bulk production,adoption and lack of charging stations increase the stress of power stations due to modern-day lifestyles. If Electricvehicles demand increases drastically then conventional power stations will not bear their demand and if theygenerate electricity by conventional means it will be very costly and may further add greenhouse gases. Therefore,this research provides the techno-economic assessment of a stand-alone renewable-dependent electric vehiclecharging station, excluding any burden on electrical utility. The proposed study is carried out in Bahria Town,Karachi, a city in Pakistan. In this study, HOMER Pro software was utilized for techno-economic assessment. Ahybrid system comprising solar Photovoltaic/Wind Turbine/Fuel cells and battery storage is included in the *** and wind resources were taken from NASA’s website, where charging stations will be integrated. The overallresults show promising in terms of total Net Present Cost and the Cost of Energy which are 2.72M $ and 0.237 $,respectively. The total system generation is 3,598 Megawatt hours per year, and the total energy consumption is 885Megawatt hours per year.

关键词： Electrical vehicle techno economic analysis solar energy wind energy hydrogen energy

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Effect of pre-twinning and heat treatment on formability of AZX311 Mg alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 1154-1169页

作者： mahesh Panchal Lalit Kaushik Min-Seong Kim Ravi Kottan Renganayagalu Shi-Hoon Choi Jaiveer Singh Department of Mechanical Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Department of Metallurgical and Materials Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Energy Materials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang-roSeongbuk-guSeoul 02792Republic of Korea Department of Advanced Components and Materials Engineering Sunchon National University255 Jungang-roSuncheonJeonnam 57922Republic of Korea

In this study,the effects of pre-strain-induced tensile twins(TTWs)and controlled heat treatment on the formability behavior of AZX311 Mg alloy sheets were investigated.A 4%compressive strain was applied to pre-strain the sheets using the in-plane compression(IPC)technique along the rolling direction(RD)to introduce *** pre-strained(PS)samples were subsequently heat-treated at 250℃,350℃,and 400℃ independently for 1 hr,and are termed as PSA1,PSA2,and PSA3,*** cupping tests were conducted to assess the formability of the sheet samples under different initial *** results showed that the PS sample heat-treated at 250℃ for 1hr exhibited a decrease in the Erichsen index(IE)compared to the as-rolled sample,whereas PSA2 and PSA3 samples showed an increase in IE *** analysis revealed that most of the TTWs generated through pre-twinning were stable at 250℃;however,the twin volume fraction reduced to 41%at 350℃ compared to the PS samples due to enhanced thermal activity at that ***,PSA2 samples showed severe grain coarsening in some areas of the sample,and the fraction of such grains increased in the PSA3 *** stretch formability(IE value)of PSA2 samples showed a 32.3%increase compared to the as-rolled ***,the analysis of the deformed specimen at failure under the Erichsen test indicated that considerable detwinning occurs in the PS and PSA1 samples,whereas dislocation slip activity dominates in the PSA2 and PSA3 samples during stretch *** from detwinning and dislocation slip,deformation twins were also observed in all samples after the Erichsen ***,this work highlights the importance of texture control and its underlying mechanisms via pre-twinning followed by heat treatment and their impact on the room temperature(RT)stretch formability of AZX311 Mg alloy sheets.

关键词： Mg alloys Pre-twinning Texture Formability EBSD.

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Spatial Attention Integrated EfficientNet Architecture for Breast Cancer Classification with Explainable AI

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Computers, Materials & Continua 2024年第9期80卷 5029-5045页

作者： Sannasi Chakravarthy Bharanidharan Nagarajan Surbhi Bhatia Khan Vinoth Kumar Venkatesan mahesh Thyluru Ramakrishna Ahlam AlMusharraf Khursheed Aurungzeb Department of Electronics and Communication Engineering Bannari Amman Institute of TechnologySathyamangalam638402India School of Computer Science Engineering and Information Systems(SCORE) Vellore Institute of TechnologyVellore632014India School of Science Engineering and EnvironmentUniversity of SalfordManchesterM54WTUK Department of Computer Science&Engineering Faculty of Engineering and TechnologyJAIN(Deemed-to-be University)Bengaluru562112India Department of Management College of Business AdministrationPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Adjunct Research Faculty Centre for Research Impact&OutcomeChitkara UniversityRajpura140401India

Breast cancer is a type of cancer responsible for higher mortality rates among *** cruelty of breast cancer always requires a promising approach for its earlier *** light of this,the proposed research leverages the representation ability of pretrained EfficientNet-B0 model and the classification ability of the XGBoost model for the binary classification of breast *** addition,the above transfer learning model is modified in such a way that it will focus more on tumor cells in the input ***,the work proposed an EfficientNet-B0 having a Spatial Attention Layer with XGBoost(ESA-XGBNet)for binary classification of *** this,the work is trained,tested,and validated using original and augmented mammogram images of three public datasets namely CBIS-DDSM,INbreast,and MIAS *** accuracy of 97.585%(CBISDDSM),98.255%(INbreast),and 98.91%(MIAS)is obtained using the proposed ESA-XGBNet architecture as compared with the existing ***,the decision-making of the proposed ESA-XGBNet architecture is visualized and validated using the Attention Guided GradCAM-based Explainable AI technique.

关键词： EfficientNet mammograms breast cancer Explainable AI deep-learning transfer learning

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Comparative study of thulium fiber laser versus holmium:yttrium-aluminum-garnet laser for ureteric stone management with semi-rigid ureteroscopy: A prospective, single-center study

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Asian Journal of Urology 2024年第3期11卷 460-465页

作者： Ankit Gupta Arvind P.Ganpule Ankush Puri Abhishek G.Singh Ravindra B.Sabnis mahesh R.Desai Muljibhai Patel Urological Hospital NadiadGujaratIndia

Objective:To compare the efficacy and safety of thulium fiber laser(TFL)and holmium:yttrium-aluminum-garnet(Ho:YAG)laser for ureteric stone management with semi-rigid ***:In a prospective study from January 2020 to December 2021,we compared 40 patients in each group who underwent semi-rigid ureteroscopic lithotripsy with TFL and that with Ho:YAG *** volume,stone density,stone fragmentation rates,total lasing time,total operative time,endoscopic vision,retropulsion and stone free rates were analyzed in both groups and ***:Mean stone volume was comparable in the TFL group and the Ho:YAG laser group(282.45[standard deviation,SD 139.79]mm3 vs.279.49[SD 312.52]mm3;p=0.964).Mean stone density was also comparable in the TFL group and the Ho:YAG laser group(1135.30[SD 317.04]Hounsfield unit vs.1131.75[SD 283.03]Hounsfield unit;p=0.959).The mean stone fragmentation rates calculated as stone volume divided by lasing time were 25.85(SD 10.61)mm3/min and 21.37(SD 14.13)mm3/min in the TFL group and the Ho:YAG laser group,respectively(p=0.113).The mean total lasing time(10.15[SD]4.69 min vs.11.43[SD 4.56]min;p=0.222),mean operative time(25.13[SD 9.51]min vs.25.54[SD 10.32]min;p=0.866),and mean total hospital stay(2.62[SD 0.77]days vs.2.61[SD 0.84]days;p=0.893)were comparable in the TFL group and in the Ho:YAG *** vision was better and retropulsion was less in the TFL *** stone-free rate at 1 month postoperatively was slightly better in the TFL group(100%vs.90%;p=0.095).

关键词： Laser Stone Urolithiasis Thulium Holmium

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40-meter-long REBCO tapes with critical current over 4,000 A/12 mm at 4.2 K and 13 T by advanced MOCVD

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Superconductivity 2024年第1期9卷 29-34页

作者： mahesh Paidpilli Chirag Goel Bhabesh Sarangi Siwei Chen Eduard Galstyan Jan Jaroszynski Griffin Bradford Dmytro Abraimov Venkat Selvamanickam Department of Mechanical Engineering Advanced Manufacturing InstituteTexas Center for SuperconductivityUniversity of HoustonHoustonTexasUSA AMPeers LLC HoustonTexasUSA National High Magnetic Field Laboratory TallahasseeFloridaUSA

REBa_(2)Cu_(3)O_(7−δ)(REBCO,RE=rare earth)tapes doped with 5%and 15%Zr have been scaled up to lengths more than 40 m in a pilot‐scale advanced metal organic chemical vapor deposition(A‐MOCVD)*** precursor compositions used for the long tapes were guided by a study of the influence of(Ba+dopant)/Cu content on the critical current density(Jc)of 5 and 15 mol.%Hf‐and Zr‐added tapes at 4.2 K and 13 *** 40‐mlong tapes exhibited a critical current(Ic)over 4,000 A/12 mm at 4.2 K and 13 T as well as over 1,400 A/12 mm at 20 K and 20 *** critical current densities of a 40‐m‐long tape doped with 5%Zr at 4.2 K measured at the National High Magnetic Field Laboratory(NHMFL)were>10 MAcm^(−2)and>5 MAcm^(−2)at 14 T and 30 T,respectively,which are over three times those of commercial REBCO *** infield Jc of 5%Zradded 40‐m‐long tapes was similar to those of previously‐reported high‐performance short samples made with 15%Zr or *** results demonstrate the excellent potential of A‐MOCVD for manufacturing high Ic REBCO tapes for use in ultrahigh‐field magnet applications.

关键词： High‐temperature superconductors MOCVD REBCO Critical current

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Long-term outcomes of urethral balloon dilation for anterior urethral stricture: A prospective cohort study

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Asian Journal of Urology 2024年第3期11卷 480-485页

作者： Ahmed M.Abdel Gawad Abhijit Patil Abhishek Singh Arvind P.Ganpule Ravindra B.Sabnis mahesh R.Desai Department of Urology Muljibhai Patel Urological HospitalNadiadIndia Department of Urology Faculty of MedicineAl-Azhar UniversityDamiettaEgypt

Objective:To prospectively follow up a cohort of anterior urethral stricture disease patients managed with balloon dilation(BD)for 3 years to evaluate the long-term outcomes and to study factors that contribute to ***:This study included men who had urethral BD for significant anterior urethral stricture disease between January 2017 and March *** about the patient age,stricture characteristics,and recurrence date were recorded,along with information on postoperative indwelling catheter use and operative ***,information about the self-calibration procedure was collected and where available,free flow(FF)measurements during the follow-up period were recorded and *** was defined as a lack of symptoms and acceptable FF rates(maximum flow rate>12 mL/s).Results:The final analysis was conducted on 187 *** mean follow-up period was 37 *** long-term overall success rate at the end of our study was 66.8%.Our recurrence rate was 7.4%at 12 months,24.7%at 24 months,and reached 33.2%at the end of our *** time to recurrence ranged from 91 days to 1635 days,with a mean of 670 *** stricture-free survival was significantly shorter with lengthy peno-bulbar(p=0.031)and multiple strictures(p=0.015),and in the group of patients who were not committed to self-calibration protocol(p<0.011).However,post-procedural self-calibration was the most important factor that may have decreased the incidence of recurrence(odds ratioZ5.85).Adjuvant self-calibration after BD not only reduced the recurrence rate from 85.4%in the non-self-calibration group to 15.1%in the self-calibration one(p<0.001),but also improved the overall stricture-free survival and FF parameters.

关键词： Balloon dilation Internal urethrotomy Recurrence Self-calibration Urethral stricture

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