Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation:Evaluating susceptibility to the development of obesity and NAFLD
作者机构:National Institute of ImmunologyNew Delhi 100067India Center for Cellular and Molecular BiologyHyderabad 500007India Regional Center for BiotechnologyFaridabad 121001India
出 版 物:《Genes & Diseases》 (基因与疾病(英文))
年 卷 期:2024年第11卷第3期
页 面:34-38页
核心收录:
学科分类:0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金:funded currently by a DBT/WellcomeTrust IndiaAlliance India
摘 要:Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.