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Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization:State-of-the-art in bone and associated tissue regeneration

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Bioactive Materials 2023年第10期28卷 284-310页

作者： Sayan Deb Dutta Tejal V.Patil Keya Ganguly Aayushi Randhawa ki-taek lim Department of Biosystems Engineering Kangwon National UniversityChuncheon24341Republic of Korea Institute of Forest Science Kangwon National UniversityChuncheon24341Republic of Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Republic of Korea

Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering, wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells and body cells determines the fate of healing or inflammation. Although several reports have demonstrated that tissue regeneration depends on spatial and temporal regulation of the biophysical or biochemical microenvironment of the biomaterial, the underlying molecular mechanism behind immunomodulation is still under consideration for developing immunomodulatory scaffolds. Currently, most fabricated immunomodulatory platforms reported in the literature show regenerative capabilities of a particular tissue, for example, endogenous tissue (e.g., bone, muscle, heart, kidney, and lungs) or exogenous tissue (e.g., skin and eye). In this review, we briefly introduced the necessity of the 3D immunomodulatory scaffolds and nanomaterials, focusing on material properties and their interaction with macrophages for general readers. This review also provides a comprehensive summary of macrophage origin and taxonomy, their diverse functions, and various signal transduction pathways during biomaterial-macrophage interaction, which is particularly helpful for material scientists and clinicians for developing next-generation immunomodulatory scaffolds. From a clinical standpoint, we briefly discussed the role of 3D biomaterial scaffolds and/or nanomaterial composites for macrophage-assisted tissue engineering with a special focus on bone and associated tissues. Finally, a summary with expert opinion is presented to address the challenges and future necessity of 3D bioprinted immunomodulatory materials for tissue engineering.

关键词： Macrophage Immunomodulation Biomaterials 3D bioprinting Tissue engineering

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Understanding cell-extracellular matrix interactions for topology-guided tissue regeneration

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BIOCELL 2023年第4期47卷 789-808页

作者： AAYUSHI RANDHAWA SAYAN DEB DUTTA KEYA GANGULY TEJAL V.PATIL RACHMI LUTHFIKASARI ki-taek lim Department of Biosystems Engineering Kangwon National UniversityChuncheon24341Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Korea

Tissues are made up of cells and the extracellular matrix(ECM)which surrounds *** cells and tissues are actively adaptable to enduring significant stress that occurs in daily *** astonishing mechanical stress develops due to the interaction between the live cells and the non-living *** in the matrix microenvironment can sense the signals and forces produced and initiate a signaling cascade that plays a crucial role in the body’s normal functioning and influences various properties of the native cells,including growth,proliferation,and ***,the matrix’s characteristic features also impact the repair and regeneration of the damaged *** current study reviewed how the cell-ECM interaction regulates cellular behavior and physicochemical ***,we have described the response of cells to mechanical stresses,the importance of substrate stiffness and geometry in tissue regeneration,and the development of scaffolds to mimic the nature of native ECM in 3D for tissue engineering applications has also been ***,the study summarizes the conclusions and promising prospects based on the cell-ECM interplay.

关键词： ECM Stress Mechanical force Scaffold Mechanotransduction Tissue engineering

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Mesenchymal stem cells,the secretome and biomaterials:Regenerative medicine application

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BIOCELL 2022年第10期46卷 2201-2208页

作者： ki-taek lim TEJAL V.PATIL DINESH KPATEL SAYAN DEB DUTTA KEYA GANGULY AAYUSHI RANDHAWA Department of Biosystems Engineering Interdisciplinary Program in Smart AgricultureKangwon National UniversityChuncheon341Korea

Mesenchymal stem cells(MSCs)are multipotent cells usually isolated from bone marrow,endometrium,adipose tissues,skin,and dental *** played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material ***,MSCs have been widely explored for their application in regenerative medicine and COVID-19 *** approaches to evaluate the future of biomaterials and stem cell properties have been ***,misconceptions and ethical issues still exist,such as MSCs being non-angiogenic,anti-apoptotic,and immunoregulatory *** stem cells isolation primarily requires the consent of donors and can include the killing of fertilized *** issues generate questions related to ethical and moral ***,MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory *** are capable of secreting a broad range of biomolecules such as proteins,nucleic acids,exosomes,microRNAs,and membrane vesicles,collectively known as *** are released in response to the surrounding *** this article,we briefly address topics related to the therapeutic potential of MSCs as an advanced approach in the field of regenerative medicine and various perspectives.

关键词： Mesenchymal Stem Cells Secretome Biomaterials Regenerative Medicine

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Nanocellulose,a versatile platform:From the delivery of active molecules to tissue engineering applications

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Bioactive Materials 2022年第3期7卷 566-589页

作者： Tejal V.Patil Dinesh K.Patel Sayan Deb Dutta Keya Ganguly Tuhin Subhra Santra ki-taek lim Department of Biosystems Engineering Institute of Forest ScienceKangwon National UniversityChuncheon24341Republic of Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Republic of Korea Deptarment of Engineering Design Indian Institute of TechnologyMadras600036India

Nanocellulose,a biopolymer,has received wide attention from researchers owing to its superior physicochemical properties,such as high mechanical strength,low density,biodegradability,and *** can be extracted from wide range of sources,including plants,bacteria,and *** on the extraction process and dimensions(diameter and length),they are categorized into three main types:cellulose nanocrystals(CNCs),cellulose nanofibrils(CNFs),and bacterial nanocellulose(BNC).CNCs are a highly crystalline and needle-like structure,whereas CNFs have both amorphous and crystalline regions in their *** is the purest form of *** nanocellulose properties can be tuned by chemical functionalization,which increases its applicability in biomedical *** review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules,such as drugs,proteins,and ***-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and *** applications of nanocellulose and its composites in tissue engineering have been ***,the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.

关键词： Nanocellulose Chemical functionalization Drug delivery Protein delivery Plasmid delivery Tissue engineering

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Exercise therapy for sarcopenia and diabetes

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World Journal of Diabetes 2023年第5期14卷 565-572页

作者： Seung-taek lim Sunghwun Kang Institute of Sports and Arts Convergence(ISAC) Inha UniversityIncheon 22212South Korea Waseda Institute for Sport Sciences Waseda UniversitySaitama 341-0018Japan Laboratory of Exercise Physiology College of ArtCulture and EngineeringKangwon National UniversityChuncheon-si 24341South Korea Interdisciplinary Program in Biohealth-machinery convergence engineering Kangwon National UniversityChuncheon-si 24341South Korea

Aging is characterized by the gradual deterioration of function at the molecular,cellular,tissue,and organism levels in *** typical diseases caused by changes in body composition,as well as functional decline in the human body’s organs due to aging include sarcopenia and metabolic *** accumulation of dysfunctional agingβcells with age can cause decreased glucose tolerance and *** decline has a multifactorial origin,involving lifestyle habits,disease triggers,and age-dependent biological *** reduced function ofβcells in elderly people lowers insulin sensitivity,which affects protein synthesis and interferes with muscle *** functional decrease and aggravation of disease in elderly people with less regular exercise or physical activity causes imbalances in food intake and a continuous,vicious *** contrast,resistance exercise increases the function ofβcells and protein synthesis in elderly *** this review,we discuss regular physical activities or exercises to prevent and improve health,which is sarcopenia as decreased muscle mass and metabolic disorders as diabetes in the elderly.

关键词： Elderly Diabetes Sarcopenia Resistance exercise Aging Muscle

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A Comparison of GPS- and NWP-derived PW Data over the Korean Peninsula

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Advances in Atmospheric Sciences 2010年第4期27卷 871-882页

作者： Ha-taek KWON Eui-Hyun JUNG Gyu-Ho lim School of Earth and Environmental Sciences Seoul National University Seoul 151-172 Korea

Precipitable Water （PW） derived from Global Positioning System （GPS） measurements and numerical weather prediction （NWP） model analysis data were compared to further evaluate the effcacy of applying GPS-derived PW to the NWP model. The spatial and temporal variations of GPS-derived PW during a rainfall event were also examined. GPS-derived PW measurements show good agreement with the behavior of water vapor at a high spatial resolution during the analysis period. Temporal anomalies of GPS-derived PW moving along with the front are successfully detected by the GPS array. Large positive anomalies of GPS-derived PW are indicated immediately before a rainfall event, and the intensity of these positive anomalies do not seem to decrease significantly as the precipitation system passes. These results indicate that the Korean GPS network may have great potential as a PW sensor over the Korean Peninsula. In contrast with GPS-derived PW, NWP-derived PW shows negative biases. These biases appear to stem mainly from the differences between modeled and actual GPS site elevations, as GPS sites were generally located at elevations lower than those employed by the NWP model. However, there still exists a discernable dry bias after a PW correction is applied to NWP-derived PW. GPS-derived PW better reflects the spatial and temporal moisture variations of precipitation systems, as compared to NWP-derived PW. These results provide entirely new information for improving the regional NWP system, since GPS-derived PW produced with data from the Korean GPS network may be incorporated into the NWP model to improve rainfall forecasts.

关键词： GPS precipitable water numerical weather prediction model dry bias

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Enhanced osteogenic differentiation of human periodontal ligament stem cells by suberoylanilide hydroxamic acid

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BIOCELL 2020年第3期44卷 389-400页

作者： YUNZE XUAN BIN JIN SAYAN DEB DUTTA MENGMENG LIU ZAIXIAN SHEN XIWEN LIU YANG KANGJUAN lim ki-taek Department of Stomatology Affiliated Hospital of Yanbian UniversityYanji133000China Department of Immunology and Molecular Microbiology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul08826South Korea Affiliated Hospital of Yanbian University Yanji133000China Department of Cell Biology and Medical Genetics Yanbian University Medical CollegeYanji133000China Department of Biosystems Engineering Kangwon National UniversityChuncheon24341South Korea

Periodontitis is a type of chronic inflammation in the gingival tissue caused by infectious bacteria colonizing the surface of the teeth,leading to the destruction of tooth-supporting tissues and loss of alveolar *** hydroxamic acid(SAHA),a class of histone deacetylase(HDAC)inhibitor,has the potential to stimulate osteoblast differentiation by acetylating histone proteins,and thus suppressing the expression of adipogenic and chondrogenic ***,the effect of SAHA on the differentiation of human periodontal ligament stem cells(hPDLSCs)is yet to be ***,we investigated the effects of SAHA on in vitro proliferation and differentiation of hPDLSCs by MTT assay,Alizarin Red-S,and alkaline phosphatase staining,and real-time ***,300 ng/mL SAHA treatment enhanced the proliferation and mineralization of hPDLSCs,indicating their osteogenic ***,a significant enhancement of osteogenesis gene markers and proteins was *** also demonstrated that ERK is a positive regulator of Runx2 transcription factors during osteoblast *** results indicate that SAHA may be a useful osteogenic induction agent for periodontal bone regeneration.

关键词： Suberoylanilide hydroxamic acid Histone deacetylase Osteoblast hPDLSCs Alkaline phosphatase Periodontal bone regeneration

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Improving Method of Anomaly Detection Performance for Industrial IoT Environment

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Computers, Materials & Continua 2022年第9期72卷 5377-5394页

作者： Junwon kim Jiho Shin ki-Woong Park Jung taek Seo Department of Information Security Engineering Gachon UniversitySeongnam13120Korea Police Science Institute Korea National Police UniversityAsan31539Korea SysCore Lab. Sejong UniversitySeoul05006Korea Department of Computer Engineering Gachon UniversitySeongnam13120Korea

Industrial Control System(ICS),which is based on Industrial IoT(IIoT),has an intelligent mobile environment that supports various mobility,but there is a limit to relying only on the physical security of the ICS *** to various threat factors that can disrupt the workflow of the IIoT,machine learning-based anomaly detection technologies are being presented;it is also essential to study for increasing detection performance to minimize model errors for promoting stable ICS *** this paper,we established the requirements for improving the anomaly detection performance in the IIoT-based ICS environment by analyzing the related *** that,we presented an improving method of the performance of a machine learning model specialized for IIoT-based ICS,which increases the detection rate by applying correlation coefficients and clustering;it provides a mechanism to predict thresholds on a ***,we adopted the HAI dataset environment that actively reflected the characteristics of IIoT-based ICS and demonstrated that performance could be improved through comparative experiments with the traditional method and our proposed *** presented method can further improve the performance of commonly applied error-based detection techniques and includes a primary method that can be enhanced over existing detection techniques by analyzing correlation coefficients between features to consider feedback between ICS *** can contribute to improving the performance of several detection models applied in ICS and other areas.

关键词： Industrial IoT industrial control system anomaly detection clustering algorithm correlation coefficient

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Repair of a large patellar cartilage defect using human umbilical cord blood-derived mesenchymal stem cells:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12665-12670页

作者： Jun-Seob Song ki-taek Hong ki Jeon Song Seok Jung kim Department of Orthopedic Surgery Gangnam JS HospitalSeoul 06053South Korea Department of Orthopedic Surgery Uijeongbu Street Mary’s HospitalCollege of MedicineThe Catholic University of KoreaUijeongbu 11765GyeonggidoSouth Korea

BACKGROUND Patellar dislocation may cause cartilage defects of various *** defects commonly require surgical treatment;however,conventional treatments are *** SUMMARY A 15-year-old male with a large patellar cartilage defect due to patellar dislocation was treated via human umbilical cord blood-derived mesenchymal stem cell(hUCB-MSC)*** our knowledge,this is the first report of this treatment for this *** patient recovered well as indicated by good visual analog scale,International Knee Documentation Committee and McMaster Universities Osteoarthritis Index *** resonance imaging showed cartilage regeneration 18 mo *** Umbilical cord blood-derived hUCB-MSCs may be a useful treatment option for the repair of large patellar cartilage defects.

关键词： Cartilage defect Umbilical cord Mesenchymal stem cells Patellar dislocation Magnetic resonance imaging Case report

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World Journal of Clinical Cases 2021年第24期9卷 7205-7211页

作者： So-My Koo ki-Up kim Yang-ki kim Soo-taek Uh Department of Internal Medicine Soonchunhyang University Seoul HospitalSeoul 04401South Korea

BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-Tkis)are tolerable drugs used for patients with EGFR-mutant advanced non-small cell lung cancer(NSCLC).Serious adverse reactions are uncommon compared with cytotoxic *** SUMMARY A 52-year-old man presented with general weakness and *** had been taking erlotinib for 11 mo to treat *** pathological diagnosis from the right upper lobe mass was adenocarcinoma with an EGFR mutation in exon 21(L858R).He had previously received paclitaxel/carboplatin,gemcitabin/vinorelbine chemotherapy,stereotactic radiosurgery for brain metastasis,and whole-brain radiotherapy as treatment for *** diagnosed the patient with acute myeloid leukemia(AML).During the induction and consolidation chemotherapy for AML,the erlotinib was *** complete remission of the AML was achieved,since the lung masses were increased,pemetrexed/cisplatin for the NSCLC was *** two cycles of chemotherapy,the cytopenia was *** relapse occurred with the same *** Therapy-related acute myeloid neoplasm(t-MN)is a rare but fatal late *** a patient may be taking EGFR-Tkis,the possibility of t-MN should be *** studies are needed to determine whether EGFR-Tki usage is a predisposing factor for t-MN.

关键词： Acute myeloid leukemia Erlotinib Neoplasm,second primary Non-small cell lung cancer Case report

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