Understanding cell-extracellular matrix interactions for topology-guided tissue regeneration

作     者：AAYUSHI RANDHAWA SAYAN DEB DUTTA KEYA GANGULY TEJAL V.PATIL RACHMI LUTHFIKASARI KI-TAEK LIM 

作者机构：Department of Biosystems EngineeringKangwon National UniversityChuncheon24341Korea Interdisciplinary Program in Smart AgricultureKangwon National UniversityChuncheon24341Korea 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2023年第47卷第4期

页      面：789-808页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Basic Research Program through the National Research Foundation of Korea(NRF) which is financed by the Ministry of Education(Grant Nos.2018R1A6A1A03025582 2019R1D1A3A03103828 2022R1I1A3063302) Korea 

主　　题：ECM Stress Mechanical force Scaffold Mechanotransduction Tissue engineering 

摘      要：Tissues are made up of cells and the extracellular matrix(ECM)which surrounds *** cells and tissues are actively adaptable to enduring significant stress that occurs in daily *** astonishing mechanical stress develops due to the interaction between the live cells and the non-living *** in the matrix microenvironment can sense the signals and forces produced and initiate a signaling cascade that plays a crucial role in the body’s normal functioning and influences various properties of the native cells,including growth,proliferation,and ***,the matrix’s characteristic features also impact the repair and regeneration of the damaged *** current study reviewed how the cell-ECM interaction regulates cellular behavior and physicochemical ***,we have described the response of cells to mechanical stresses,the importance of substrate stiffness and geometry in tissue regeneration,and the development of scaffolds to mimic the nature of native ECM in 3D for tissue engineering applications has also been ***,the study summarizes the conclusions and promising prospects based on the cell-ECM interplay.