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RNA viromes of Dermacentor nuttalli ticks reveal a novel uukuvirus in Qinghai Province,China

Virologica Sinica 2024年第4期39卷 537-545页

作者： Yaohui Fang Jun Wang jianqing sun Zhengyuan Su Shengyao Chen Jian Xiao Jun Ni Zhihong Hu Yubang He Shu Shen Fei Deng Key Laboratory of Special Pathogens and Biosafety and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 101408China Qinghai Lake National Nature Reserve Administration Xining 810000China Hubei Jiangxia Laboratory Wuhan 430200China Xinjiang Key Laboratory of Vector-borne Infectious Diseases Urumqi830002China

Ticks are a major parasite on the Qınghai-Tibet Plateau,western China,and represent an economic burden to agriculture and animal *** research on tick-borne pathogens that threaten humans and animals,the viromes of dominant tick species in this area remain *** this study,we collected Dermacentor nuttalli ticks near Qınghai Lake and identified 13 viruses belonging to at least six families through metagenomic *** viruses were of high abundance in pools,including Xınjiang tick-associated virus 1(XJTAV1),and three novel viruses:Qınghai Lake virus 1,Qınghai Lake virus 2(QHLV1,and QHLV2,unclassified),and Qınghai Lake virus 3(QHLV3,genus Uukuvirus of family Phenuiviridae in order Bunyavirales),which lacks the M *** minimum infection rates of the four viruses in the tick groups were 8.2%,49.5%,6.2%,and 24.7%,respectively,suggesting the prevalence of these viruses in *** ticks.A putative M segment of QHLV3 was identified from the next-generation sequencing data and further characterized for its signal peptide cleavage site,N-glycosylation,and transmembrane ***,we probed the L,M,and S segments of other viruses from sequencing data of other tick pools by using the putative M segment sequence of *** revealing the viromes of *** ticks,this study enhances our understanding of tick-borne viral communities in highland *** putative M segment identified in a novel uukuvirus suggests that previously identified uukuviruses without M segments should have had the same genome organization as typical *** findings will facilitate virus discovery and our understanding of the phylogeny of tick-borne uukuviruses.

关键词： Dermacentor nuttalli Qınghai Province Virome Uukuvirus M segment

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Stem cell-based ischemic stroke therapy:Novel modifications and clinical challenges

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 18-34页

作者： Yuankai sun Xinchi Jiang jianqing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China Department of Pharmacy The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Ischemic stroke(IS)causes severe disability and high mortality *** cell(SC)therapy exhibits unique therapeutic potential for IS that differs from current ***’s cell homing,differentiation and paracrine abilities give hope for *** studies on SC modification have enhanced therapeutic effects for IS,including gene transfection,nanoparticle modification,biomaterial modification and *** improve survival rate,homing,neural differentiation,and paracrine abilities in ischemic ***,many problems must be resolved before SC therapy can be clinically *** issues include production quality and quantity,stability during transportation and storage,as well as usage ***,we reviewed the brief pathogenesis of IS,the“multi-mechanism”advantages of SCs for treating IS,various SC modification methods,and SC therapy *** aim to uncover the potential and overcome the challenges of using SCs for treating IS and convey innovative ideas for modifying SCs.

关键词： Ischemic stroke Stem cell therapy Stem cell modification Cell therapy challenge

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Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds,2014–2015

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Virologica Sinica 2016年第4期31卷 300-305页

作者： Yuhai Bi Jianjun Chen Zhenjie Zhang Mingxin Li Tianlong Cai Kirill Sharshov Ivan Susloparov Alexander Shestopalov Gary Wong Yubang He Zhi Xing jianqing sun Di Liu Yingxia Liu Lei Liu Wenjun Liu Fumin Lei Weifeng Shi George F. Gao Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhen 518112China CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Pathogenic Microbiology and Immunology(CASPMI) Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institute of Pathogen Biology Taishan Medical CollegeTaishan 271000China CAS Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Center for Influenza Research and Early-warning(CASCIRE) Chinese Academy of SciencesBeijing 100101China Research Institute of Experimental and Clinical Medicine Novosibirsk State UniversityNovosibirsk 630090Russia Qinghai Lake National Nature Reserve State Forestry AdministrationXining 810007China Office of Director-General Chinese Center for Disease Control and Prevention(China CDC)and Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseZhejiang UniversityHangzhou 310058China

A novel Clade 2.***.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to *** on the genetic and phylogenetic analyses,the viruses possess a stable gene constellation with a Clade 2.***.2.1c HA,a H9N2-derived PB2 gene and the other six genes of Asian *** Clade 2.***.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain(A/Alberta/01/2014).Further analysis showed that similar viruses have been circulating in wild birds in China,Russia,Dubai(Western Asia),Bulgaria and Romania(Europe),as well as domestic poultry in some regions of *** affected areas include the Central Asian,East Asian-Australasian,West Asian-East African,and Black Sea/Mediterranean *** results show that the novel Clade 2.***.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds,thus posing a serious threat to wild birds and potentially humans.

关键词： H5N1 highly pathogenic avian influenza virus Clade 2.3.2.1c outbreak migratory birds

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Divergent responses of runoff to climate change in the upper basins of the Third Pole dominated by westerlies and monsoon

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Science China Earth Sciences 2024年第8期67卷 2592-2614页

作者： Qikai sun Fengge SU He sun State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China

The diverse climates,distribution of snow and glaciers,and geographic locations directly affect the runoff response to climate change in the upper basins of the Third *** present,a comprehensive analysis of runoff variations and their distinct responses to climate change in the westerlies-and monsoon-dominated upper basins is still *** study comprehensively analyzed annual runoff variations in westerlies-dominated basins(the upper basins of the Aksu(UAKS),Syr Darya(USRD),Yarkant(UYK),Hotan(UHT),Amu Darya(UAMD),and Indus(UI))and monsoon-dominated basins(the upper basins of the Yangtze(UYA),Yellow(UYE),Lancang(ULC),Nujiang(UNJ),and Yarlung Zangbo(UYZ))of the Third Pole from 1961 *** multi-source meteorological data and large-scale circulation factors,this study investigated the divergent responses of runoff in the upper basins to climate change,and explored the large-scale circulation mechanisms underlying runoff variations in these upper *** results showed that:(1)The annual runoff in the majority of upper basins(except for the UYE and UYZ)exhibited an increasing trend,and the annual runoff in the UAKS,UYK,and UI showed a significant increasing trend from1961 to *** annual runoff in the upper basins of the Third Pole changed abruptly from decreasing to increasing between the 1980s and 2000s,with the exception of the UYE.(2)The runoff in the monsoon-dominated upper basins has been controlled primarily by changes in precipitation over the past 55 *** contrast,the runoff in the westerlies-dominated upper basins exhibited three distinct long-term responses to climate change:temperature-dominated(UYK and UHT),precipitation-dominated(USRD and UAMD),and the combined influence of precipitation and temperature(UAKS and UI).Since the 1960s,the sensitivity of runoff to warm season temperature changes in the most westerlies-dominated upper basins has decreased,while the response of runoff to precipitation changes has intensified.(3)The stud

关键词： Upper basins of the Third Pole Climate change Westerlies and monsoon Runoff variations Large-scale circulation factors

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New perspectives on deep carbon cycling

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Science China Earth Sciences 2024年第8期67卷 2411-2422页

作者： Weidong sun Center of Deep Sea Research Key Laboratory of Ocean Observation and ForecastingInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

The proto-atmosphere serves as a crucial starting point for the carbon *** based on atmospheric data from Mars and Venus suggest that Earth's proto-atmosphere contained>110 bar of CO_(2)and>2.6 bar of *** protoatmosphere had over 1000 bar of water vapor during the magma ocean stage,assuming the proto-ocean had a volume of two oceans of *** this stage both water and carbon dioxide were in a supercritical state at the magma-atmosphere *** serpentinization reactions occurred due to rock-water interaction,producing abundant ***,nitrogen is reduced to ammonia,and carbon dioxide to methane,forming carbonate *** proto-atmosphere dominated by methane,ammonia,and hydrogen formed a significant amount of amino acids through *** process is essential not only to the origin of life,but also to the early carbon-nitrogen cycle on *** the Hadean eon,a large amount of CO_(2)was sequestered as carbonate and organic ***,it mainly entered the deep mantle through mantle overturn or *** the mantle transition zone,carbonate undergoes“Redox freezing”,where carbonate is reduced to diamond through oxidation of ferrous iron in the *** the lower mantle,Fe^(2+)undergoes disproportionation reactions,forming Fe^(3+)and metallic *** these,Fe^(3+)mainly resides in bridgmanite,thereby increasing the oxygen fugacity of the lower mantle,while metallic iron falls to the Earth's *** distribution of carbon in the mantle is crucial for deep carbon *** density curves of diamond and mantle peridotite melt intersect at the bottom of the mantle transition zone(about 660 km).This density crossover leads to the accumulation of diamond during the magma ocean *** materials such as subducting slabs enter the lower mantle,compensatory upwelling of lower mantle material *** enters the upper mantle,decomposes,releasing Fe^(3+)ions and oxidizes diamond

关键词： Carbon cycling Proto-atmosphere Amino acids Subduction initiation Passive margin subduction Atmospheric carbon dioxide

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企业境外工程承包中的成本管理

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国际商务财会 2007年第1期217卷 31-32页

作者：孙坚清中工国际

TCL在汤姆逊业务的落败,明基的西门子业务申请破产……中国企业在走向世界市场时面临着方方面面的问题,融资、投资、运营、税务、劳工、社会责任等等。中国企业需要学习的东西太多。本刊开设“国际运作”栏目,将从企业跨国经营的各方面... 详细信息

TCL在汤姆逊业务的落败,明基的西门子业务申请破产……中国企业在走向世界市场时面临着方方面面的问题,融资、投资、运营、税务、劳工、社会责任等等。中国企业需要学习的东西太多。本刊开设“国际运作”栏目,将从企业跨国经营的各方面进行深入的探讨,希望能为“走出去”的企业拓展思路。

关键词：成本财政管理境外工程工程承包企业企业管理自有资金资金筹集信用额度

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对外工程承包项目的收入确认

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国际商务财会 2007年第9期 41-42页

作者：孙坚青中工国际股份有限公司

8月,本刊记者参加一个上市公司CFO研讨会。会上有人提出:对外工程承包收入何时确认收入,正式入账,才合规、合情、合理。此文可回答上述问题。

关键词：工程承包项目收入确认工程承包业务货物贸易贸易业务结算方式预收账款销售收入

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The precipitation and effect of topologically close-packed phases in Ni-based single crystal superalloys

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Journal of Materials Science & Technology 2024年第6期173卷 149-169页

作者： Jinguo Li Jingxia sun Jinlai Liu Xiaofeng sun Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

The precipitation of topologically close-packed(TCP)phases is the result of microstructure instabilities of Ni-based *** review seeks to comprehensively collate all the available information on TCP phases in SX superalloys based on the latest ***,the thermodynamics and kinetics of the TCP phase precipitation are ***,the morphology,composition and orientation of TCP phases and their sequential transformation are summarized in ***,the factors affecting the precipitation of these phases are sorted ***,the proposed damage mechanisms of TCP phases are ***,several control and prediction methods of the TCP phase precipitation are reviewed,so the alloy designer can better balance the relationship between microstructure stabilities and properties of the superalloy.

关键词： Ni-based superalloys Topologically close packed(TCP)phases Precipitation Microstructure stability Properties

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Fossil Equidae in the Linxia Basin with Biostratigraphic and Paleozoogeographic Significance

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 1-9页

作者： sun Boyang Key Laboratory of Vertebrate Evolution and Human Origins of the Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China

The Linxia Basin is characterized by an abundance of Cenozoic sediments,that contain exceptionally rich fossil *** are abundant in the Linxia Basin,the fossil record of equids in this region including 16 species that represent 10 *** comparison to other classic late Cenozoic areas in China,the Linxia Basin stands out,because the fauna and chronological data accompanying Linxia equids render them remarkably useful for *** anchitheriines in the region,such as Anchitherium and Sinohippus,represent early equids that appeared in the late stages of the middle and late Miocene,*** the equines,most species of Chinese hipparions have been identified in the Linxia Basin and some species of the genera Hipparion and Hippotherium have FAD records for ***,Equus eisenmannae is one of the earliest known species of Equus in the Old World and is well-represented at the Longdan *** species with precise geohistorical distributions can serve as standards for high-resolution chronological units within this *** at the eastern margin of the Tibetan Plateau and subject to considerable uplift,the Linxia Basin has served as a biogeographic transition area for equids throughout the late Cenozoic.

关键词： Equidae Cenozoic biostratigraphy paleozoogeography Linxia Basin

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Achieving simultaneously high conversion and high selectivity for light olefins directly producing from syngas

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Science China Chemistry 2024年第3期67卷 753-754页

作者： Yuhan sun Shanxi Research Institute Huairou Research LaboratoryTaiyuan 030032China Institute of Carbon Neutrality ShanghaiTech UniversityShanghai 201210China

The activity and selectivity are two primary indexes of a successful catalyst for chemical reactions. However,achieving a high activity and a high selectivity simultaneously is a long-standing challenge in catalysis, the socalled activity-selectivity trade-off. In the article recently published in Science, a research team led by Prof.

关键词： selectivity simultaneous catalysis

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