Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds,2014–2015

作     者：Yuhai Bi Jianjun Chen Zhenjie Zhang Mingxin Li Tianlong Cai Kirill Sharshov Ivan Susloparov Alexander Shestopalov Gary Wong Yubang He Zhi Xing Jianqing Sun Di Liu Yingxia Liu Lei Liu Wenjun Liu Fumin Lei Weifeng Shi George F. Gao 

作者机构：Shenzhen Key Laboratory of Pathogen and ImmunityState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhen 518112China CAS Key Laboratory of Special Pathogens and BiosafetyWuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Pathogenic Microbiology and Immunology(CASPMI)Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institute of Pathogen BiologyTaishan Medical CollegeTaishan 271000China CAS Key Laboratory of Zoological Systematics and EvolutionInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Center for Influenza Research and Early-warning(CASCIRE)Chinese Academy of SciencesBeijing 100101China Research Institute of Experimental and Clinical MedicineNovosibirsk State UniversityNovosibirsk 630090Russia Qinghai Lake National Nature ReserveState Forestry AdministrationXining 810007China Office of Director-GeneralChinese Center for Disease Control and Prevention(China CDC)and Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseZhejiang UniversityHangzhou 310058China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2016年第31卷第4期

页      面：300-305页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 090601[农学-基础兽医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 09[农学] 0906[农学-兽医学] 

基　　金：supported by grants from the National Natural Science Foundation of China (31311120063,81470096,31570026,31471253) the Ministry of Education and Science of the Russian Federation (Chinese-Russian project:RFMEFI61315X0045) the intramural special grant for influenza virus research from the Chinese Academy of Sciences (KJZD-EW-L09) the IDRCAPEIR program (106915-001) Special Project of Ministry of Science and Technology (2013FY113500) supported by the “Taishan Scholar” project of Shandong Province 

主　　题：H5N1 highly pathogenic avian influenza virus Clade 2.3.2.1c outbreak migratory birds 

摘      要：A novel Clade 2.***.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to *** on the genetic and phylogenetic analyses,the viruses possess a stable gene constellation with a Clade 2.***.2.1c HA,a H9N2-derived PB2 gene and the other six genes of Asian *** Clade 2.***.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain(A/Alberta/01/2014).Further analysis showed that similar viruses have been circulating in wild birds in China,Russia,Dubai(Western Asia),Bulgaria and Romania(Europe),as well as domestic poultry in some regions of *** affected areas include the Central Asian,East Asian-Australasian,West Asian-East African,and Black Sea/Mediterranean *** results show that the novel Clade 2.***.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds,thus posing a serious threat to wild birds and potentially humans.