Stem cell-based ischemic stroke therapy:Novel modifications and clinical challenges

作     者：Yuankai Sun Xinchi Jiang Jianqing Gao Yuankai Sun;Xinchi Jiang;Jianqing Gao

作者机构：Institute of PharmaceuticsCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative MedicineZhejiang UniversityHangzhou 310058China Department of PharmacyThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2024年第19卷第1期

页      面：18-34页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(U22A20383,82003668) the Natural Science Foundation of Zhejiang Province(LD22H300002,LQ21H300002) Ningbo Technology Innovation 2025 Major Special Project(2022Z150) 

主　　题：Ischemic stroke Stem cell therapy Stem cell modification Cell therapy challenge 

摘      要：Ischemic stroke(IS)causes severe disability and high mortality *** cell(SC)therapy exhibits unique therapeutic potential for IS that differs from current ***’s cell homing,differentiation and paracrine abilities give hope for *** studies on SC modification have enhanced therapeutic effects for IS,including gene transfection,nanoparticle modification,biomaterial modification and *** improve survival rate,homing,neural differentiation,and paracrine abilities in ischemic ***,many problems must be resolved before SC therapy can be clinically *** issues include production quality and quantity,stability during transportation and storage,as well as usage ***,we reviewed the brief pathogenesis of IS,the“multi-mechanismadvantages of SCs for treating IS,various SC modification methods,and SC therapy *** aim to uncover the potential and overcome the challenges of using SCs for treating IS and convey innovative ideas for modifying SCs.