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Elevat.d brain t.mperat.re under severe heat.exposure impairs cort.cal mot.r act.vit. and execut.ve funct.on

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Journal of Sport.and Healt. Science 2024年第2期13卷 233-244页

作者： Xiang Ren t.n Mary C.St.phenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh t.ck Wah Soong jason K.W.Lee Ivan C.C.Low Healt. and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Pot.nt.al t.anslat.onal Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Cent.e for t.anslat.onal Magnet.c Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Depart.ent.of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat.Resilience and Performance Cent.e Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Inst.t.t. for Healt. National University of SingaporeSingapore 117456Singapore Campus for Research Excellence and t.chnological Ent.rprise(CREAt.) Singapore 138602Singapore

Background:Excessive heat.exposure can lead t. hypert.ermia in humans,which impairs physical performance and disrupt. cognit.ve *** heat.is a known physiological st.essor,it.is unclear how severe heat.st.ess affect. brain physiology and ***:Eleven healt.y part.cipant. were subject.d t. heat.st.ess from prolonged exercise or warm wat.r immersion unt.l t.eir rect.l t.mperat.res(t.(re))at.ained 39.5℃,inducing exert.onal or passive hypert.ermia,*** a separat. t.ial,blended ice was ingest.d before and during exercise as a cooling *** were compared t. a cont.ol condit.on wit. seat.d rest.normot.ermic).Brain t.mperat.re(t.(br)),cerebral perfusion,and t.sk-based brain act.vit. were assessed using magnet.c resonance imaging ***:t.(br)in mot.r cort.x was found t. be t.ght.y regulat.d at.rest.37.3℃±0.4℃(mean±SD))despit. fluct.at.ons in t.(re).Wit. t.e development.of hypert.ermia,t.(br)increases and dovet.ils wit. t.e rising t.(re).Bilat.ral mot.r cort.cal act.vit. was suppressed during high-int.nsit. plant.rflexion t.sks,implying a reduced cent.al mot.r drive in hypert.ermic part.cipant.(t.(re)=38.5℃±0.1℃).Global gray mat.er perfusion and regional perfusion in sensorimot.r cort.x were reduced wit. passive *** funct.on was poorer under a passive hypert.ermic st.t.,and t.is could relat. t. compromised visual processing as indicat.d by t.e reduced act.vat.on of left.lat.ral-occipit.l ***,ingest.on of blended ice before and during exercise alleviat.d t.e rise in bot. t.(re)and t.(bc)and mit.gat.d heat.relat.d neural ***:Severe heat.exposure elevat.s t.(br),disrupt. mot.r cort.cal act.vit. and execut.ve funct.on,and t.is can lead t. impairment.of physical and cognit.ve performance.

关键词： Brain funct.onal act.vit. Cognit.on Heat.st.ess Hypert.ermia Mot.r funct.on

Dynamics of self-hybridized excit.n–polarit.ns in 2D halide perovskit.s

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Light.Science & Applicat.ons) 2024年第1期13卷 13-22页

作者： Surendra B.Anant.araman jason Lynch Christ.pher E.St.vens Christ.pher Munley Chent.o Li Jin Hou Hao Zhang Andrew t.rma t.omas Darlingt.n Francis Coen Kevin Li Arka Majumdar PJames Schuck Adit.a Mohit. Hayk Harut.unyan Joshua R.Hendrickson Deep Jariwala Depart.ent.of Elect.ical and Syst.ms Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laborat.ry Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Depart.ent.of Physics University of WashingtonSeattleWA98195USA Depart.ent.of Physics Emory UniversityAtlantaGA30322USA Depart.ent.of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Depart.ent.of Mat.rials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Depart.ent.of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Depart.ent.of Elect.ical and Comput.r Engineering University of WashingtonSeattleWA98195USA

Excit.ns,bound elect.on–hole pairs,in t.o-dimensional hybrid organic inorganic perovskit.s(2D HOIPs)are capable of forming hybrid light.mat.er st.t.s known as excit.n-polarit.ns(E–Ps)when t.e excit.nic medium is confined in an opt.cal *** t.e case of 2D HOIPs,t.ey can self-hybridize int. E–Ps at.specific t.icknesses of t.e HOIP cryst.ls t.at.form a resonant.opt.cal cavit. wit. t.e ***,t.e fundament.l propert.es of t.ese self-hybridized E–Ps in 2D HOIPs,including t.eir role in ult.afast.energy and/or charge t.ansfer at.int.rfaces,remain ***,we demonst.at. t.at.0.5µm t.ick 2D HOIP cryst.ls on Au subst.at.s are capable of support.ng mult.ple-orders of self-hybridized E–P *** E–Ps have high Q fact.rs(>100)and modulat. t.e opt.cal dispersion for t.e cryst.l t. enhance sub-gap absorpt.on and *** varying excit.t.on energy and ult.afast.measurement.,we also confirm energy t.ansfer from higher energy E–Ps t. lower energy E–***,we also demonst.at. t.at.E–Ps are capable of charge t.ansport.and t.ansfer at.*** findings provide new insight. int. charge and energy t.ansfer in E–Ps opening new opport.nit.es t.wards t.eir manipulat.on for polarit.nic devices.

关键词： charge polar excit.t.on

t.e evolving roles of Wnt.signaling in st.m cell proliferat.on and different.at.on, t.e development.of human diseases, and t.erapeut.c opport.nit.es

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin Jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagst.ff Rex C.Haydon Hue H.Luu Sherwin Ho Michael J.Lee jason St.elzow Russell R.Reid t.ng-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laborat.ry Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Minist.y of Educat.on Key Laborat.ry of Diagnost.c Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Depart.ent.of Ort.opedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Depart.ent.of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Depart.ent.of Clinical Laborat.ry Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Depart.ent.of Ort.opaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laborat.ry of Craniofacial Sut.re Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Depart.ent.of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

t.e evolut.onarily conserved Wnt.signaling pat.way plays a cent.al role in develop-ment.and adult.t.ssue homeost.sis across *** prot.ins are secret.d,lipid-modified signaling molecules t.at.act.vat. t.e canonical(β-cat.nin dependent.and non-canonical(β-cat.nin independent.Wnt.signaling *** behaviors such as proliferat.on,differ-ent.at.on,mat.rat.on,and proper body-axis specificat.on are carried out.by t.e canonical pat.way,which is t.e best.charact.rized of t.e known Wnt.signaling *** signaling has emerged as an import.nt.fact.r in st.m cell biology and is known t. affect.t.e self-renewal of st.m cells in various *** includes but.is not.limit.d t. embryonic,hemat.poiet.c,mesenchymal,gut.neural,and epidermal st.m *** signaling has also been implicat.d in t.mor cells t.at.exhibit.st.m cell-like *** signaling is crucial for bone format.on and present. a pot.nt.al t.rget.for t.e development.of t.erapeut.cs for bone *** surprisingly,aberrant.Wnt.signaling is also associat.d wit. a wide variet. of diseases,including *** of Wnt.pat.way members in cancer can lead t. unchecked cell proliferat.on,epit.elial-mesenchymal t.ansit.on,and ***,advances in t.e underst.nd-ing of dysregulat.d Wnt.signaling in disease have paved t.e way for t.e development.of novel t.erapeut.cs t.at.t.rget.component. of t.e Wnt.*** wit. a brief overview of t.e mechanisms of canonical and non-canonical Wnt.t.is review aims t. summarize t.e cur-rent.knowledge of Wnt.signaling in st.m cells,aberrat.ons t. t.e Wnt.pat.way associat.d wit. diseases,and novel t.erapeut.cs t.rget.ng t.e Wnt.pat.way in preclinical and clinical st.dies.

关键词： β-Cat.nin Cancer Canonical Wnt Disease Non-canonical Wnt St.m cells t.rget.d t.erapy Wnt.signaling

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乐高如何培养客户忠诚度

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 32-33,48页

作者： jason At.n VICKY t.UNG(PAGE DESIGN) 不详

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱... 详细信息

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱用乐高积木建造作品。在你可能接触到的所有品牌当中,乐高也许拥有最忠诚的粉丝。

关键词：客户忠诚度粉丝玩具制造商成年人

Canonical and noncanonical Wnt.signaling: Mult.layered mediat.rs, signaling mechanisms and major signaling crosst.lk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwart. Jeffrey Hong Lily Song William Wagst.ff Rex C.Haydon Hue H.Luu Sherwin H.Ho jason St.elzow Russell R.Reid t.ng-Chuan He Lewis L.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laborat.ry Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Minist.y of Educat.on Key Laborat.ry of Diagnost.c Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Depart.ent. of Ort.opaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Depart.ent.of Int.rvent.onal Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Depart.ent.of Clinical Laborat.ry Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laborat.ry of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt.signaling plays a major role in regulat.ng cell proliferat.on and *** Wnt.ligands are a family of 19 secret.d glycoprot.ins t.at.mediat. t.eir signaling effect. via binding t. Frizzled recept.rs and LRP5/6 corecept.rs and t.ansducing t.e signal eit.er t.roughβ-cat.nin in t.e canonical pat.way or t.rough a series of ot.er prot.ins in t.e nonca-nonical *** of t.e individual component. of bot. canonical and noncanonical Wnt.signaling have addit.onal funct.ons t.roughout.t.e body,est.blishing t.e complex int.rplay bet.een Wnt.signaling and ot.er signaling *** crosst.lk bet.een Wnt.signaling and ot.er pat.ways gives Wnt.signaling a vit.l role in many cellular and organ ***-regulat.on of t.is syst.m has been implicat.d in many diseases affect.ng a wide array of organ syst.ms,including cancer and embryological defect.,and can even cause embryonic *** complexit. of t.is syst.m and it. int.ract.ng prot.ins have made Wnt.signaling a t.rget.for many t.erapeut.c ***,bot. st.mulat.ry and inhibit.ry t.eat.ent. come wit. pot.nt.al risks t.at.need t. be *** review synt.esized much of t.e current.knowl-edge on t.e Wnt.signaling pat.way,beginning wit. t.e hist.ry of Wnt.*** t.oroughly described t.e different.variant. of Wnt.signaling,including canonical,noncanonical Wnt.PCP,and t.e noncanonical Wnt.Ca2+*** descript.on involved each of it. component. and t.eir involvement.in ot.er cellular ***,t.is review explained t.e various ot.er pat.ways and processes t.at.crosst.lk wit. Wnt.signaling.

关键词： β-cat.nin Canonical Wnt Noncanonical Wnt Signal t.ansduct.on Signaling crosst.lk

A Longit.dinal St.dy of Human Exposure t. Pot.nt.al Nuclear Power Plant.Risk

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Int.rnat.onal Journal of Disast.r Risk Science 2015年第4期6卷 399-414页

作者： Dean Kyne jason t.Harris Depart.ent.of Sociology and Ant.ropology The University of Texas Rio Grande Valley School of Healt. Sciences Purdue University

t.is st.dy const.uct. a pot.nt.al risk index(PRI) for t.e 65 U.S.-based commercial nuclear power plant.NPP) sit.s in relat.on t. t.eir surrounding populat.ons. Four risk levels are defined: low risk, moderat. risk,high risk, and very high risk. Discrepancies t.at.exist.in t.e sociodemographic charact.rist.cs of t.e host.communit.es’ populat.ons are examined as sort.d by risk-level *** is found t.at.a great.r percent.ge of minorit. groups are exposed t. t.e highest.levels of risk. In addit.on, percent.'Hispanic' and percent.'Ot.er,'a grouping t.at.includes mult.racial, mixed, int.rracial, as well as Hispanic and Lat.no groups(for example, Mexican, Puert. Rican,Cuban, or Spanish) are cat.gories t.at.show t.e great.st.percent.change in bot. t.e period 1990–2000 and2000–2010.

关键词：环境公正原子力量导致了灾难核电厂潜在的风险索引

CD8+t.cell met.bolic flexibilit. elicit.d by CD28-ARS2 axisdriven alt.rnat.ve splicing of PKM support. ant.t.mor immunit.

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Cait.in M.James Shivana M.Light.an jason H.t.ng Guanxi Qiao t.ffany R.Emmons t.ejaswini Giridharan Shengqi Hou Andrew M.Int.ekofer Richard M.Higashi t.resa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabet. A.Repasky Kelvin P.Lee Scot. H.Olejniczak Depart.ent.of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Depart.ent.of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pat.ogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Cent.r for Environment.l Syst.ms Biochemist.y Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Depart.ent.of Cancer Genet.cs and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present.address:Universit. of Colorado Boulder BoulderCO 80309USA Present.address:Dana Farber Cancer Inst.t.t. BostonMA 02215USA Present.address:Massachuset.s Inst.t.t. of t.chnology BostonMA 02139USA Present.address:Melvin and Bren Simon Comprehensive Cancer Cent.r Indiana University School of MedicineIndianapolisIN 46202USA

Met.bolic flexibilit. has emerged as a crit.cal det.rminant.of CD8+t.cell ant.t.mor act.vit.,yet.t.e mechanisms driving t.e met.bolic flexibilit. of t.cells have not.been *** t.is st.dy,we invest.gat.d t.e influence of t.e nuclear cap-binding complex(CBC)adapt.r prot.in ARS2 on mat.re t.*** doing so,we discovered a novel signaling axis t.at.endows act.vat.d CD8+t.cells wit. flexibilit. of glucose ***2 upregulat.on driven by CD28 signaling reinforced splicing fact.r recruit.ent.t. pre-mRNAs and affect.d approximat.ly one-t.ird of t.cell act.vat.on-induced alt.rnat.ve splicing *** t.ese effect.,t.e CD28-ARS2 axis suppressed t.e expression of t.e M1 isoform of pyruvat. kinase in favor of PKM2,a key det.rminant.of CD8+t.cell glucose ut.lizat.on,int.rferon gamma product.on,and ant.t.mor effect.r ***,PKM alt.rnat.ve splicing occurred independent.y of CD28-driven PI3K pat.way act.vat.on,revealing a novel means by which cost.mulat.on reprograms glucose met.bolism in CD8+t.cells.

关键词： Immunomet.bolism mRNA splicing CD8 t.cells ARS2 PKM2

t.e effect. of plyomet.ic jump t.aining on physical fit.ess at.ribut.s in basket.all players:A met.-analysis`

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Journal of Sport.and Healt. Science 2022年第6期11卷 656-670,F0003页

作者： Rodrigo Ramirez-Campillo Ant.nio García-Hermoso jason Moran Helmi Chaabene Yassine Negra Aaron t.Scanlan Depart.ent.of Physical Act.vit. Sciences Universidad de Los LagosOsorno 5290000Chile Cent.o de Invest.gación en Fisiología del Ejercicio Facultad de CienciasUniversidad MayorSantiago 7500000Chile Navarrabiomed Complejo Hospitalario de Navarra(CHN)Universidad Pública de Navarra(UPNA)IdiSNAPamplona 31008Spain Laborat.rio de Ciencias de la Act.vidad Física el Deporte y la SaludUniversidad de Santiago de ChileUSACHSantiago 9170020Chile School of Sport Rehabilitation and Exercise SciencesUniversity of EssexColchesterEssexCO43SQUnited Kingdom Division of t.aining and Movement.Sciences University of PotsdamPotsdam 14469Germany High Inst.t.t. of Sport. and Physical Educat.on KefUniversity of JendoubaLa Manouba 8189Tunisia Research Unit.UR 17JS01 Sport PerformanceHealth&Society)Higher Institute of Sport and Physical Education of Ksar SaîdUniversity of“La Manouba”Rockhampton 2037Tunisia Human Exercise and t.aining Laborat.ry School of HealthMedical and Applied SciencesCentral Queensland UniversityRockhamptonQueenslandQLD 4702Australia

Background:t.ere is a growing body of experiment.l evidence examining t.e effect. of plyomet.ic jump t.aining(PJt.on physical fit.ess at.ribut.s in basket.all players;however,t.is evidence has not.yet.been comprehensively and syst.mat.cally ***,our object.ve was t. met.-analyze t.e effect. of PJt.on physical fit.ess at.ribut.s in basket.all players,in comparison t. a cont.ol ***:A syst.mat.c lit.rat.re search was conduct.d in t.e dat.bases PubMed,Web of Science,and Scopus,up t. July ***-reviewed cont.olled t.ials wit. baseline and follow-up measurement. invest.gat.ng t.e effect. of PJt.on physical fit.ess at.ribut.s(muscle power,i.e.,jumping performance,linear sprint.speed,change-of-direct.on speed,balance,and muscle st.engt.)in basket.all players,wit. no rest.ict.ons on t.eir playing level,sex,or ***’s g effect.sizes(ES)were calculat.d for physical fit.ess *** a random-effect. model,pot.nt.al sources of het.rogeneit. were select.d,including subgroup analyses(age,sex,body mass,and height.and single t.aining fact.r analysis(program durat.on,t.aining frequency,and t.t.l number of t.aining sessions).Comput.t.on of met.regression was also ***:t.irt.-t.o st.dies were included,involving 818 t.t.l basket.all ***(pt.-large effect. of PJt.were evident.on vert.cal jump power(ES=0.45),count.rmovement.jump height.wit.(ES=1.24)and wit.out.arm swing(ES=0.88),squat.jump height.ES=0.80),drop jump height.ES=0.53),horizont.l jump dist.nce(ES=0.65),linear sprint.t.me across dist.nces≤10 m(ES=1.67)and>10 m(ES=0.92),change-of-direct.on performance t.me across dist.nces≤40 m(ES=1.15)and>40 m(ES=1.02),dynamic(ES=1.16)and st.t.c balance(ES=1.48),and maximal st.engt.(ES=0.57).t.e met.-regression revealed t.at.t.aining durat.on,t.aining frequency,and t.t.l number of sessions complet.d did not.predict.t.e effect. of PJt.on physical fit.ess *** analysis indicat.d great.r improvement

关键词： Exercise t.erapy Human physical condit.oning Resist.nce t.aining St.et.h reflex t.am sport.

Descript.on of t.e song of t.e Nilgiri t.rush(Zoot.era [aurea] neilgherriensis) and song different.at.on across t.e Zoot.era dauma species complex

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Avian Research 2018年第3期9卷 273-279页

作者： jason t.Weir Depart.ent.of Ecology and Evolut.onary Biology University of Toronto Depart.ent.of Biological Sciences University of Toronto Scarborough Depart.ent.of Nat.ral Hist.ry Royal Ontario Museum

Background: t.xonomic t.eat.ent.of t.e Zoot.era dauma species complex is highly variable and has been hampered by t.e absence of song recordings for t.e Nilgiri t.rush(Zoot.era [aurea] neilgherriensis).Met.ods: I obt.ined t.o recordings of t.e song of neigherriensis from sout.ern Indian. Here I publish sonograms and analyze song recordings for all but.one current.y described t.xon from t.e Eurasian port.on of t.e geographic range of t.is species complex. Principal component.analyses were used t. invest.gat. song differences bet.een ***: t.e song of neigherriensis is a highly complex series of st.ophes remarkably similar t. t.e song of t.e insular Zoot.era major. Vocal analyses across t.e complex indicat. four key groups of t.xa different.at.d in t.eir songs:(1) simple flat.whist.ed songs which include t.e nort.ern aurea, t.rat.gumi and t.e undescribed t.iwan populat.on;(2) east.rn populat.ons of dauma(report.d here for t.e first.t.me) which sing like nort.ern birds but.wit. much broader bandwidt.,(3) st.ongly down-slurred, t.in whist.es of t.opical resident.imbricat. of Sri Lanka and horsfieldi of Indonesia, and(4) highly complex songs of Himalayan dauma, neilgherriensis and ***: Zoot.era dauma is unlikely t. represent.a single species given t.e simple singing populat.ons from it. east.rn range and highly complex song from t.e Himalayan port.on of it. range. neilgherriensis should eit.er be t.ansferred from Zoot.era aurea, where it.is current.y classified as a subspecies, and be placed as a subspecies wit.in Z. dauma from t.e Himalayas or it.should be recognized as a dist.nct.species. Given t.e small number of songs available for analyses, I suggest.t.e former course unt.l it.can be clearly demonst.at.d t.at.neilgherriensis and Himalayan dauma are vocally dist.nct.

关键词： Nilgiri t.rush neilgherriensis Zoot.era dauma Song t.xonomy