The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities
作者机构：School of MedicineRosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology LaboratoryDepartment of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicineand Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic SurgeryThe First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of UrologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory MedicineShanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic SurgeryChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and DevelopmentDepartment of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of NeurologyThe First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第3期
页 面：155-187页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 0817[工学-化学工程与技术] 100101[医学-人体解剖与组织胚胎学] 10[医学]
基 金：supported in part by research grants from the National Institutes of Health(No.CA226303 to TCH and No.DE030480 to RRR) JF was supported in part by research grants from the Natural Science Foundation of China(No.82102696) the 2019 Science and Technology Research Plan Project of Chongqing Education Commission(China)(No.KJQN201900410) the 2019 Funding for Postdoctoral Research(Chongqing Human Resources and Social Security Bureau No.298,Chongqing,China) WW was supported by the Medical Scientist Training Program of the National Institutes of Health(No.T32 GM007281) This project was also supported in part by The University of Chicago Cancer Center Support Grant(No.P30CA014599) the National Center for Advancing Translational Sciences(NCATS)of the National Institutes of Health(No.5UL1TR002389)
主 题：β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling
摘 要：The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.
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