Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk
作者机构：Chicago Medical SchoolRosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology LaboratoryDepartment of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicineand Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and UrologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional NeurologyThe First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical Laboratory MedicineShanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical EngineeringVanderbilt UniversityNashvilleTN 37235USA Laboratory of Craniofacial Biology and DevelopmentDepartment of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第1期
页 面：103-134页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学]
基 金：supported in part by research grants from the National Institutes of Health(No.CA226303 to TCH and No.DE030480 to RRR) the American Shoulder and Elbow Surgeons PJI Research Grant(LLS).JF was supported in part by research grants from the Natural Science Foundation of China(No.82102696) the 2019 Science and Technology Research Plan Project of Chongqing Education Commission(China)(No.KJQN201900410) the 2019 Funding for Postdoctoral Research(Chongqing Human Resources and Social Security Bureau No.298) WW was supported by the Medical Scientist Training Program of the National Institutes of Health(No.T32 GM007281) This project was also supported in partby The University of Chicago Cancer Center Support Grant(No.P30CA014599) the National Center for Advancing Translational Sciences(NCATS)of the National Institutes of Health through Grant Number 5UL1TR002389
主 题：β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk
摘 要：Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.
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