Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

作     者：Xiang Ren Tan Mary C.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuck Wah Soong Jason K.W.Lee Ivan C.C.Low Xiang Ren Tan;Mary C.Stephenson;Sharifah Badriyah Alhadad;Kelvin W.Z.Loh;Tuck Wah Soong;Jason K.W.Lee;Ivan C.C.Low

作者机构：Health and Social SciencesSingapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research ProgrammeYong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Centre for Translational Magnetic Resonance ResearchYong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of PhysiologyYong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance CentreYong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for HealthNational University of SingaporeSingapore 117456Singapore Campus for Research Excellence and Technological Enterprise(CREATE)Singapore 138602Singapore 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2024年第13卷第2期

页      面：233-244页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 1202[管理学-工商管理] 04[教育学] 

基　　金：supported by Defence Innovative Research Program(DIRP)Grant(PA No.9015102335)from Defence Research&Technology Office Ministry of Defence Singapore 

主　　题：Brain functional activity Cognition Heat stress Hyperthermia Motor function 

摘      要：Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).With the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.