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SEGREGATION EFFECT ON SURFACE COMPOSITION IN ALLOY SPUTTERING

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Chinese Physics Letters 1990年第3期7卷 140-143页

作者： ZHENG Liping LI Risheng LI Mingyao cui fuzhai Shanghai Institute of Nuclear Research Academia SinicaP.O.Box 8204Shanghai201800 Institute of Metal Research Academia SinicaShenyang110015 Department of Engineering Physics Tsinghua UniversityBeijing100084

The modified dynamic TCIS(Transport and atomic Collision cascade of energetic Ions an Solids)Monte Carlo program including the radiation-enhanced Gibbsian segregation(REGS)is employed to estimate the compositional distributions at surface of the Au_(0.56)Cu_(0.44) alloy under 2keV Ar^(+) ion bombardment at high *** calculation results exhibit that the Au composition enriches in the first layer(74 at.%),depletes in the second layer(37 at.%)and gradually rises with depth to the bulk *** effect of the relation between sputter depth and segregation layer on the surface concentration of Au_(0.56)Cu_(0.44) is also discussed.

关键词： alloy layer SURFACE

Study on vertical mandibular distraction osteogenesis using magnesium alloy on canine

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Progress in Natural Science:Materials International 2014年第5期24卷 446-451页

作者： Chengyue Wang Shufeng Wang Yusheng Yao fuzhai cui Department of Stomatology Centeral Hospital of Jinzhou Clinical Hospital of Liaoning Medical College Stomatological Hospital of Xuzhou Stomatological Hospital of Liaoning Medical College Department of Materials Science & Engineering Tsinghua University

The bone formation feasibility by a novel magnesium alloy device was evaluated using a canine vertical mandibular distraction osteogenesis(DO) model. Osteotomies were performed in the area where last 3 star’s teeth of left mandibular were pulled out before 3 months. Both AZ31 magnesium alloy(n ? 6) and 316 L stainless steel(n ? 6) distraction devices were implanted. The distraction osteogenesis was carried out with a latency of 5 days after mandibular osteotomy. Distraction proceeded at a rate of 0.3 mm/8 h for 7 days and followed by 4 weeks of consolidations. The evaluations were conducted by scanning electron microscopy(SEM) and histological examinations. There were osteoblasts and trabecular bones formations manifestly in both groups. There was no significant difference in the bone mineral density between the two groups. The surface of the magnesium alloy was much more cracked and uneven, resulting from the surface pitting corrosion. The crew nails were closely combined with the surrounding bone tissue. AZ31 magnesium alloy exhibited a certain degradation rate in mandibular and did not post a negative effect on the kidney and liver. The observations in magnesium alloys group is consistent with the stainless steel group.

关键词： Magnesium alloy Distraction osteogenesis Degradability Bone formation Canine

Mediating Mesenchymal Stem Cells Responses and Osteopontin Adsorption via Oligo(ethylene glycol)-amino Mixed Self-assembled Monolayers

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Journal of Materials Science & Technology 2016年第9期32卷 966-970页

作者： Lijing Hao Tianjie Li Naru Zhao fuzhai cui Chang Du Yingjun Wang School of Materials Science and Engineering South China University of TechnologyGuangzhou 510640China National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou 510006China Department of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Oligo（ethylene glycol）（-OEG） and amino （-NH2） mixed self-assembled monolayers （SAMs） were employed as model substrates to investigate the effect of charge density on the fate of mesenchymal stem cells （MSCs） and osteopontin （OPN） adsorption. We found that all surfaces presenting -NH2 groups favored cell responses regardless of the surface charge. Meanwhile, OPN adsorption could remain stable on the mixed SAMs over a certain range of charge densities. Our work provides some insights into cell responses and protein adsorption to surface charge.

关键词： Mixed self-assembled monolayers Oligo(ethylene glycol)-amino Mesenchymal stem cell Osteopontin

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A SIMULATION STUDY OF LOW ENERGY SPUTTERING ANGULAR DISTRIBUTION

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Chinese Physics Letters 1988年第4期5卷 145-148页

作者： ZHENG Liping cui fuzhai Institute of Nuclear Research Academia SinicaShanghai Ion-Beam Laboratory Institute of MetallurgyAcademia SinicaShanghai Department of Engineering Physics Qinghua UniversityBeijing

The low energy sputtering angular distributions are simulated in inert gas ion-metal target *** is found that the angular distribution of PKAs trends to an under-cosine shape,while the angular distribution of SKAs shows either a cosine one or an over-cosine one:the formation of the under-cosine sputtering angular distribution seems to come from the smaller mass ratio and the lower incident energy.

关键词： energy. angular distribution

Preparation of 3-D porous fibroin scaffolds by freeze drying with treatment of methanol solutions

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Chinese Science Bulletin 2007年第13期52卷 1791-1795页

作者： ZHAN JingLin SUN XiaoDan cui fuzhai KONG XiangDong Laboratory of Advanced Materials Department of Materials Science & Engineering Tsinghua University Beijing 100084 China Xinyuan Institute of Medicine and Biotechnology College of Life Science Zhejiang Science and Technology University Hangzhou 310029 China

In this study, silk scaffolds with appropriate porous structures were prepared by adjusting solution concentrations and providing treatment with methanol solutions in the way of freeze drying. The effects of the preparation conditions on the microstructures and properties of the scaffolds were discussed. Fibroin solutions with different concentrations of 4, 6, 8, 10 wt% were used respectively to prepare the scaffolds. The effects of the addition of 20 vol% methanol before or after freeze drying to the 4 wt% fibroin solution were investigated. As demonstrated by Scanning Electron Microscope (SEM), the fib-roin scaffolds prepared without methanol had porous microstructures composed of thin sheets, and the sizes of the pores decreased with the increase of the fibroin solution concentrations, while the scaffolds prepared in the presence of methanol showed porous microstructures formed by fine-particle aggregates. The porosities and mechanical properties of the prepared fibroin scaffolds under different conditions were tested. The crystalline structures and conformations of the fibroin scaffolds were detected by Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD).

关键词：蚕丝蛋白多孔材料冷藏干燥甲醇

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Formation of Nitride Cu3N by MeV N-Ion Implantation into Cu

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Chinese Physics Letters 1991年第10期8卷 525-528页

作者： cui fuzhai A.M.Vredenberg R.de Reus F.W.Saris Department of Materials Science and Engineering Tsinghua.Universityf Beijing 100084 FOM-Institu£e for Atomic and Molecular Physics Kruislaan 4071098 SJ AmsterdamThe Netherlands

Experimental evidences are presented to show the formation of jiiCride,Cu3N,in pure Cu sample by N-ion *** result is obtained in the case of MeV ion *** experiments showed that this compound can not be formed by N-ion implantation into Cu at incident energy of about 100keV,This Ending indicates there exist certain difFerences in phase forma-tion by ion implcLntation at the two energies.

关键词： implantation pure incident

Directing neural stem cell fate with biomaterial parameters for injured brain regeneration

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Progress in Natural Science:Materials International 2013年第2期23卷 103-112页

作者： Shenglian Yao Xi Liu Xiumei Wang Antonio Merolli Xiongbiao Chen fuzhai cui Institute for Regenerative Medicine and Biomimetic Materials Key Laboratory of Advanced Materials School of Materials Science and Engineering Tsinghua University National Engineering Laboratory for Regenerative Implantable Medical Devices Orthopaedics & Hand Surgery Unit The Catholic University School of Medicine Division of Biomedical Engineering College of Engineering University of Saskatchewan

The discovery of neural stem cells (NSCs), which have the ability to self-renew and differentiate into all types of neural lineages, offers promising prospect for the treatment of brain neurological disorders such as stroke/cerebral ischemia, traumatic brain injury and neurodegenerative disorders. However, only limited number of NSCs could survive or propagate due to tissue inflammation or blood-brain barrier. Therefore, it is necessary to develop an appropriate culture system that highly mimics the natural NSCs niche to direct stem cell fate and behavior for nerve regeneration. Both biophysical and biochemical properties of the NSC niche, including topology, mechanical properties, bioactive molecules, and their spatial and temporal presentations should be considered for the design of functionalized scaffolds, which could not only serve as the delivery vehicles of NSCs but also stimulate specific cellular responses at the molecular level, such as support endogenous or exogenous cells proliferation, migration and homing, even promote the growth of axon at the injured brain site. This review attempts to outline the varieties of biomaterial

关键词： NSCs niche Biomaterial design Brain tissue engineering Nerve regeneration

Biomechanical evaluation of different hydroxyapatite coatings on titanium for keratoprosthesis

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Frontiers of Materials Science 2015年第3期9卷 303-310页

作者： Ying DONG Zhiye QIU Xiaoyu LIU Liqiang WANG Jingxin YANG Yifei HUANG fuzhai cui Department of Ophthalmology The First Affiliated Hospital Chinese PLA General Hospital Beijing 100048 China Department of Ophthalmology Chinese PLA General Hospital Beijing 100853 China School of Materials Science and Engineering Tsinghua University Beijing 100084 China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China

Stable tissue integration is important to keratoprosthesis （KPro）. The aim of this study was to evaluate the tissue bonding ability of hydroxyapatite （HAp）-coated titanium KPro. The samples were divided into three groups： test groups （IBAD group and AD group） and Ti control. The coated samples had a HAp layer created by ion beam assisted deposition （IBAD） or aerosol deposition （AD）. The surface characteristics were analyzed with SEM, AFM, and XRD. The samples were surgically inserted into the muscles of rabbits. Eight weeks after healing, the attachment to the tissue was tested with a universal test device. The three samples exhibited distinctive surface morphology. The force to remove the HAp implants from the muscles was significantly greater than that of Ti group （P〈0.01）, with the AD samples requiring the greatest force （P〈0.01）. After removal, SEM showed that the tissue was firmly attached to the surface of AD samples. Photomicrographs of the peri-implant muscles showed a layer of aligned fibrous tissue without severe inflammation. The AD samples had more fibroblasts. Results indicate that because of enhanced mechanical adhesion of soft tissue to the implants, HAp-coated Ti by AD is a suitable KPro skirt material.

关键词： hydroxyapatite (HAp) titanium keratoprosthesis (KPro) biomechanics tissue attachment

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Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a VEGF mimetic peptide in a traumatic brain injury model in rats

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Regenerative Biomaterials 2019年第6期6卷 325-334页

作者： Jiaju Lu Fengyi Guan fuzhai cui Xiaodan Sun Lingyun Zhao Ying Wang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing Center of Neutral Regeneration and Repair Key Laboratory for Neurodegenerative Disease of the Ministry of EducationCapital Medical UniversityBeijing 100069China

Angiogenesis plays an important role in brain injury repair,which contributes to the reconstruction of regenerative neurovascular niche for promoting axonal regeneration in the lesion *** a major component of developing brain extracellular matrix,hyaluronic acid(HA)has attracted more attention as a supporting matrix for brain *** the present study,HA-KLT hydrogel was developed via modifying HA with a VEGF mimetic peptide of KLT(KLTWQELYQLKYKGI).The characterization of the hydrogel shows that it could provide a porous,three-dimensional scaffold structure,which has a large specific surface area available for cell adhesion and *** with the unmodified HA hydrogel,the HA-KLT hydrogel could effectively promote the attachment,spreading and proliferation of endothelial cells in ***,the pro-angiogenic ability of hydrogels in vivo was evaluated by implanting them into the lesion cavities in the injured rat *** results showed that the hydrogels could form a permissive interface with the host tissues at 4 weeks after ***,they could efficiently inhibit the formation of glial scars at the injured *** HA-KLT hydrogel could significantly increase the expression of endoglin/CD105 and promote the formation of blood vessels,suggesting that HA-KLT hydrogel promoted angiogenesis in ***,the HA-KLT hydrogel has the potential to repair brain defects by promoting angiogenesis and inhibiting the formation of glial-derived scar tissue.

关键词： traumatic brain injury hyaluronic acid angiogenesis VEGF mimetic peptide