Study on vertical mandibular distraction osteogenesis using magnesium alloy on canine

作     者：Chengyue Wang Shufeng Wang Yusheng Yao Fuzhai Cui 

作者机构：Department of Stomatology Centeral Hospital of Jinzhou Clinical Hospital of Liaoning Medical College Stomatological Hospital of Xuzhou Stomatological Hospital of Liaoning Medical College Department of Materials Science & Engineering Tsinghua University 

出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))

年 卷 期：2014年第24卷第5期

页      面：446-451页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by the Liaoning Department of Education of China (2009 T063) the National Basic Research Program of China (No. 2012CB619101) 

主　　题：Magnesium alloy Distraction osteogenesis Degradability Bone formation Canine 

摘      要：The bone formation feasibility by a novel magnesium alloy device was evaluated using a canine vertical mandibular distraction osteogenesis(DO) model. Osteotomies were performed in the area where last 3 star’s teeth of left mandibular were pulled out before 3 months. Both AZ31 magnesium alloy(n ? 6) and 316 L stainless steel(n ? 6) distraction devices were implanted. The distraction osteogenesis was carried out with a latency of 5 days after mandibular osteotomy. Distraction proceeded at a rate of 0.3 mm/8 h for 7 days and followed by 4 weeks of consolidations. The evaluations were conducted by scanning electron microscopy(SEM) and histological examinations. There were osteoblasts and trabecular bones formations manifestly in both groups. There was no significant difference in the bone mineral density between the two groups. The surface of the magnesium alloy was much more cracked and uneven, resulting from the surface pitting corrosion. The crew nails were closely combined with the surrounding bone tissue. AZ31 magnesium alloy exhibited a certain degradation rate in mandibular and did not post a negative effect on the kidney and liver. The observations in magnesium alloys group is consistent with the stainless steel group.