Directing neural stem cell fate with biomaterial parameters for injured brain regeneration

作     者：Shenglian Yao Xi Liu Xiumei Wang Antonio Merolli Xiongbiao Chen Fuzhai Cui 

作者机构：Institute for Regenerative Medicine and Biomimetic Materials Key Laboratory of Advanced Materials School of Materials Science and Engineering Tsinghua University National Engineering Laboratory for Regenerative Implantable Medical Devices Orthopaedics & Hand Surgery Unit The Catholic University School of Medicine Division of Biomedical Engineering College of Engineering University of Saskatchewan 

出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))

年 卷 期：2013年第23卷第2期

页      面：103-112页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：supported by Tsinghua University Initiative Scientific Research Program (No. 20121087982) 973 Program (No. 2011CB606205) National Nature Foundation of China(No. 50803031) Analysis Foundation of Tsinghua University 

主　　题：NSCs niche Biomaterial design Brain tissue engineering Nerve regeneration 

摘      要：The discovery of neural stem cells (NSCs), which have the ability to self-renew and differentiate into all types of neural lineages, offers promising prospect for the treatment of brain neurological disorders such as stroke/cerebral ischemia, traumatic brain injury and neurodegenerative disorders. However, only limited number of NSCs could survive or propagate due to tissue inflammation or blood-brain barrier. Therefore, it is necessary to develop an appropriate culture system that highly mimics the natural NSCs niche to direct stem cell fate and behavior for nerve regeneration. Both biophysical and biochemical properties of the NSC niche, including topology, mechanical properties, bioactive molecules, and their spatial and temporal presentations should be considered for the design of functionalized scaffolds, which could not only serve as the delivery vehicles of NSCs but also stimulate specific cellular responses at the molecular level, such as support endogenous or exogenous cells proliferation, migration and homing, even promote the growth of axon at the injured brain site. This review attempts to outline the varieties of biomaterial