Mediating Mesenchymal Stem Cells Responses and Osteopontin Adsorption via Oligo(ethylene glycol)-amino Mixed Self-assembled Monolayers

作     者：Lijing Hao Tianjie Li Naru Zhao Fuzhai Cui Chang Du Yingjun Wang 

作者机构：School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640China National Engineering Research Center for Tissue Restoration and ReconstructionGuangzhou 510006China Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2016年第32卷第9期

页      面：966-970页

核心收录：

学科分类：0806[工学-冶金工程] 0817[工学-化学工程与技术] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0802[工学-机械工程] 0702[理学-物理学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：supported by the National Basic Research Program of China(No.2012CB619100) the National Natural Science Foundation of China(No.51232002) the 111 Project(No.B13039) the Science and Technology Program of Guangdong Province(No.2013B010403007) 

主　　题：Mixed self assembled monolayers Oligo(ethylene glycol) amino Mesenchymal stem cell Osteopontin 

摘      要：Oligo（ethylene glycol） （-OEG） and amino （-NH2） mixed self-assembled monolayers （SAMs） were employed as model substrates to investigate the effect of charge density on the fate of mesenchymal stem cells （MSCs） and osteopontin （OPN） adsorption. We found that all surfaces presenting -NH2 groups favored cell responses regardless of the surface charge. Meanwhile, OPN adsorption could remain stable on the mixed SAMs over a certain range of charge densities. Our work provides some insights into cell responses and protein adsorption to surface charge.