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Chinese Journal of Chemistry 2024年第16期42卷 1901-1912页

作者： Ke-Xin Yang Tian-Ze li Yun-Bao Ma Yong-Cui Wang feng-jiao li Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Ten novel isocoumarins,including four pairs of enantiomers,were isolated from Artemisia dubia ***(Asteraceae).Compounds 1,2 and 3a/3b possessed a unique 6/6/6-tricyclic system comprising an unusual 1-(2-methylcyclohexyl)propan-1-one moiety fused with isocoumarin core *** 4a/4b were characterized as an unexpected 2,5-dimethylcyclohexan-1-one scaffold,and compounds 5a/5b and 6a/6b were rare 1,*** structures and absolute configurations were elucidated through spectroscopic data,X-ray crystallography,ECD and NMR calculations with DP4+*** biosynthetic pathways were proposed from the naturally occurring *** pharmacological analysis suggested that the targets of compound 1 were significantly enriched in the cell cycle and Pl3K-Akt signaling *** molecular docking revealed that compound 1 had high binding affinity with CDK2(total score:6.8717).Furthermore,compounds 1 and 2 exhibited inhibitory activity on three human hepatoma cell lines,with inhibitory ratios of 85.1% and 84.5%(HepG2),88.2% and 87.3%(Huh7),and 69.2% and 69.1%(SK-Hep-1)at 200μmol·L^(-1),respectively.

关键词： Artemisia dubia var.subdigitata Isocoumarins Antihepatoma activity Cancer Natural products X-ray diffraction

Adrenomedullin: an important participant in neurological diseases

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Neural Regeneration Research 2020年第7期15卷 1199-1207页

作者： feng-jiao li Si-Ru Zheng Dong-Mei Wang College of life Sciences Laboratory of Neuroendocrinology Provincial Key Laboratory of Developmental Biology and Neuroscience Fujian Normal University

Adrenomedullin,a peptide with multiple physiological functions in nervous system injury and disease,has aroused the interest of *** review summarizes the role of adrenomedullin in neuropathological disorders,including pathological pain,brain injury and nerve regeneration,and their *** a newly characterized pronociceptive mediator,adrenomedullin has been shown to act as an upstream factor in the transmission of noxious information for various types of pathological pain including acute and chronic inflammatory pain,cancer pain,neuropathic pain induced by spinal nerve injury and diabetic *** of glia-neuron signaling networks in the peripheral and central nervous system by adrenomedullin is involved in the formation and maintenance of morphine *** has been shown to exert a facilitated or neuroprotective effect against brain injury including hemorrhagic or ischemic stroke and traumatic brain ***,adrenomedullin can serve as a regulator to promote nerve regeneration in pathological ***,adrenomedullin is an important participant in nervous system diseases.

关键词： adrenomedullin brain injury glia mechanism morphine tolerance neural regeneration neuroprotective effect pathological pain regeneration sensitization target

Prediction of undeformed chip thickness distribution and surface roughness in ultrasonic vibration grinding of inner hole of bearings

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 311-323页

作者： Yanqin li Daohui XIANG Guofu GAO feng jiao Bo ZHAO School of Mechanical and Power Engineering Henan Polytechnic UniversityJiaozuo 454000China

Ultrasonic vibration grinding differs from traditional grinding in terms of its material removal *** randomness of grain-workpiece interaction in ultrasonic vibration grinding can produce variable chips and impact the surface roughness of ***,previous studies used iterative method to calculate the unformed chip thickness(UCT),which has low computational *** this study,a symbolic difference method is proposed to calculate the *** UCT distributions are obtained to describe the stochastic interaction characteristics of ultrasonic grinding ***,the UCT distribution characteristics under different machining parameters are ***,a surface roughness prediction model is established based on the UCT ***,the correctness of the model is verified by *** study provides a quick and accurate method for predicting surface roughness in longitudinal ultrasonic vibration grinding.

关键词： Ultrasonic vibration grinding Undeformed chip thickness(UCT) Distribution characteristics Surface roughness

Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway

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Chinese Journal of Chemistry 2023年第19期41卷 2453-2468页

作者： Wei Dong Wen-Jing Ma Yun-Bao Ma feng-jiao li Tian-Ze li Yong-Cui Wang Xiao-feng He Chang-An Geng Xue-Mei Zhang Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201 China University of Chinese Academy of Sciences Beijing100049 China

17 new guaiane-type sesquiterpenoid dimers(GSDs),artemzhongdianolides B1—B17(1—17),were isolated from Artemisia zhongdianensis under the guidance of bioassay,and elucidated by spectral analyses(HRESIMS,1D and 2D NMR,IR,ECD).The absolute configuration of compounds 1,3,7,9,10,and 13 was determined by single-crystal X-ray diffraction ***,artemzhongdianolides B1(1)and B2(2)were the first example of the GSDs fused via a C-13/C-13'single bond,and artemzhongdianolides B3—B17 were[4+2]Diels–Alder adducts of two monomeric *** of the compounds showed antihepatoma cytotoxicity with IC_(50) values ranging from 9.9 to 170.1μmol/***,artemzhongdianolide B9(9)was the most active one against three hepatoma cell lines with IC_(50) values of 13.1μmol/L(HepG2),19.5μmol/L(Huh7),and 19.5μmol/L(SK-Hep-1),and dose-dependently inhibited cell migration and invasion,induced G1 cell cycle arrest and cell apoptosis in HepG2 *** 9 might suppress HepG2 cells via affecting the p38MAPK signaling pathway suggested by machine learning approach,and significantly upregulated expression of phosphorylated p38 validated by Western blot assay.

关键词： Artemzhongdianolides B1-B17 Artemisia zhongdianensis Guaiane-type sesquiter penoid dimers Antihepatoma activity p38MAPK pathway Cancer NMR spectroscopy X-ray diffraction

Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss

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Chinese Medical Journal 2016年第8期129卷 946-952页

作者： feng-jiao li Da-Yong Wang Hong-Yang Wang li Wang feng-Bo Yang Lan Lan Jing Guan Zi-Fang Yin UII Rosenhall Lan Yu Sten Hellstrom Xi-Jun Xu Mao-li Duan Qiu-Ju Wang Department of Otolaryngology-Head and Neck Surgery Institute of Otolaryngology Chinese PLA General Hospital Beijing 100853 China Department of Otolaryngology-Head and Neck Surgery Kunming General Hospital Kunming Medical University Kunming Yunnan 650032 China Department of Audiology and Neurotology Karolinska University Hospital 17176 Stockholm Sweden Department of Clinical Science Intervention and Technology Karolinska Institute 171 76 Stockholm Sweden

Background：The prevalence of sudden sensorineural hearing loss in children （CSSNHL） is consistently ***,the pathology and prognosis of CSSNHL are still poorly *** retrospective study evaluated clinical characteristics and possible associated factors of ***：One hundred and thirty-six CSSNHL patients treated in Department of Otolaryngology-Head and Neck Surgery and Institute of Otolaryngology at Chinese PLA General Hospital between July 2008 and August 2015 were included in this *** patients were analyzed for clinical characteristics,audiological characteristics,laboratory examinations,and prognostic ***：Among the 136 patients （151 ears）,121 patients （121 ears,80.1%） were diagnosed with unilaterally CSSNHL,and 15 patients （30 ears,19.9%） with bilateral *** complete recovery rate of CSSNHL was 9.3%,and the overall recovery rate was 37.7%.We found that initial degree of hearing loss,onset of treatment,tinnitus,the ascending type audiogram,gender,side of hearing loss,the recorded auditory brainstem response （ABR）,and distortion product otoacoustic emissions （DPOAEs） had prognostic ***,ear fullness,and vertigo had no significant correlation with ***,the relevant blood tests showed 30.8% of the children had abnormal white blood cell （WBC） counts,22.1% had elevated homocysteine levels,65.8% had high alkaline phosphatase （ALP）,33.8% had high IgE antibody levels,and 86.1% had positive cytomegalovirus （CMV） IgG ***：CSSNHL commonly occurs unilaterally and results in severe hearing *** severe hearing loss and bilateral hearing loss are negative prognostic factors for hearing recovery,while positive prognostic factors include tinnitus,gender,the ascending type audiogram,early treatment,identifiable ABR waves,and ***,vertigo,and ear fullness are not correlated with the *** serologic indicators,including the level of WBC,platelet,homocysteine,A

关键词： Audiological Characteristics Children Laboratory Examinations Prognostic Factors Sudden Hearing Loss

Insight into the capacity degradation and structural evolution of single-crystal Ni-rich cathodes

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Journal of Energy Chemistry 2024年第8期95卷 68-76,I0003页

作者： Xiaodong Zhang jiao lin Ersha Fan Qingrong Huang Su Ma Renjie Chen feng Wu li li Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Advanced Technology Research Institute Beijing Institute of TechnologyJinan 250300ShandongChina Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081China

Single-crystal Ni-rich cathodes are a promising candidate for high-energy lithium-ion batteries due to their higher structural and cycling stability than polycrystalline ***,the phase evolution and capacity degradation of these single-crystal cathodes during continuous lithation/delithation cycling remains *** the mapping relationship between the macroscopic electrochemical properties and the material physicochemical properties is ***,we investigate the correlation between the physical-chemical characteristics,phase transition,and capacity decay using capacity differential curve feature identification and in-situ X-ray spectroscopic *** systematically clarify the dominant mechanism of phase evolution in aging *** high cut-off voltages can mitigate the slow kinetic and electrochemical properties of single-crystal *** also find that second-order differential capacity discharge characteristic curves can be used to identify the crystal structure disorder of Ni-rich *** findings constitute a step forward in elucidating the correlation between the electrochemical extrinsic properties and the physicochemical intrinsic properties and provide new perspectives for failure analysis of layered electrode materials.

关键词： Single-crystal cathodes Capacity decay Phase transition Differential capacity analysis

Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2019年第43期25卷 6404-6415页

作者： Xing-Xin Yang Jia-Di Wei Jian-Kang Mu Xin liu feng-jiao li Yan-Qin li Wen Gu Jing-Ping li Jie Yu College of Pharmaceutical Science Yunnan University of Chinese MedicineKunming 650500Yunnan ProvinceChina Beijing Entry-Exit Inspection and Quarantine Bureau Beijing 100026China

BACKGROUND Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for therapy of nonalcoholic fatty liver disease(NAFLD).Polygonatum kingianum(PK)has been traditionally used in China as a medicinal and nutritional ingredient for centuries and can alleviate high-fat diet(HFD)-induced NAFLD by promoting mitochondrial *** date,the underlying molecular mechanism of PK for treating mitochondrial dysfunctions and thus alleviating NAFLD remains *** To identify the molecular mechanism behind the mitochondrial regulatory action of PK against HFD-induced NAFLD in *** NAFLD model was induced in rats with *** rats were intragastrically administered PK(4 g/kg per day)for 14 *** in hepatic mitochondrial samples were profiled through ultra-high performance liquid chromatography/mass spectrometry followed by multivariate statistical analysis to find the potential biomarkers and metabolic *** PK significantly restored the metabolites’levels in the mitochondrial *** potential biomarkers were identified in the analyzed *** biomarkers are involved in riboflavin *** PK can alleviate HFD-induced NAFLD by regulating the riboflavin metabolism and further improving the mitochondrial ***,PK is a promising mitochondrial regulator/nutrient for alleviating NAFLD-associated diseases.

关键词： Metabolomics Mitochondria Multivariate statistical analysis Non-alcoholic fatty liver Polygonatum kingianum Ultra-high performance liquid chromatography/mass spectrometry

Catalytic asymmetric(3+3)cycloaddition between different 2-indolylmethanols

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Science China Chemistry 2024年第8期67卷 2629-2636页

作者： Tianzhen li Sijia liu Shufang Wu Qi Cheng Qun Chen Yinchun jiao Yuchen Zhang feng Shi School of Petrochemical Engineering School of Materials ScienceEngineeringChangzhou UniversityChangzhou 213164China Research Center of Chiral Functional Heterocycles School of Chemistry and Materials ScienceJiangsu Normal UniversityXuzhou 221116China School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

The catalytic asymmetric(3+3)cycloaddition between different 2-indolylmethanols has been established,in which a series of chiral indole-fused six-membered heterocycles were constructed in high yields with excellent *** work not only has established the first catalytic asymmetric cycloaddition between different 2-indolylmethanols but also provided a powerful strategy for constructing enantioenriched indole-fused six-membered ***,biological evaluation discovered some products with promising antitumor ***,theoretical calculations performed on the reaction pathway and activation mode provide an in-depth understanding of this catalytic asymmetric(3+3)cycloaddition among different 2-indolylmethanols,which will advance the understanding of the chemistry of indolylmethanols.

关键词： asymmetric organocatalysis chiral phosphoric acid cycloaddition enantioselectivity 2-indolylmethanol

Water-facilitated targeted repair of degraded cathodes for sustainable lithium-ion batteries

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SusMat 2024年第2期4卷 28-40页

作者： jiao lin Xiaodong Zhang Zhujie li Ersha Fan Xiaowei Lv Renjie Chen feng Wu li li Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijingChina Collaborative Innovation Center of Electric Vehicles in Beijing No.5 South Zhongguancun StreetBeijingChina Advanced Technology Research Institute Beijing Institute of TechnologyJinanChina

Directly repairing end-of-life lithium-ion battery cathodes poses significant chal-lenges due to the diverse compositions of the ***,we propose a water-facilitated targeted repair strategy applicable to various end-of-life batches and *** process involves initiating structural repair and reconstruct-ing particle morphology in degraded liMn_(2)O_(4)(LMO)through an additional thermal drive post-ambient water remanganization,achieving elemental *** to solid-phase repair,the resulting LMO material exhibits superior electrochemical and kinetic *** theoretical analysis highlights the impact of Mn defects on the structural stability and electron transfer rate of degraded *** propensity of Mn ions to diffuse within the Mn layer,specifically occupying the Mn 16d site instead of the li 8a site,theoretically sup-ports the feasibility of ambient water ***,this method proves effective in the relithiation of degraded layered cathode materials,yielding single *** combining low energy consumption,environmental friendli-ness,and recyclability,our study proposes a sustainable approach to utilizing spent *** strategy holds the potential to enable the industrial direct repair of deteriorated cathode materials.

关键词： direct repair lithium-ion batteries water-facilitated

Two sandwich-type uranyl-containing polytungstates catalyze aerobic synthesis of benzimidazoles

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Rare Metals 2024年第3期43卷 1316-1322页

作者： Yu-feng liu Qi-Long Hu Xue-jiao Chen Ke li Pei Luo Guo-Ping Yang School of Chemistry and Material Science Jiangxi Province Key Laboratory of Synthetic ChemistryJiangxi Key Laboratory for Mass Spectrometry and InstrumentationEast China University of TechnologyNanchang330013China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Diversified synthetic strategies are extremely important for the structural diversity of uranium-containing polyoxometalates(U-POMs)and their functional ***,two sandwich-type U-POMs were reported,which are Na_(5.6)K_(6.4)[(UO_(2))(H_(2)O)(TeW_(9)O_(33))]_(2)·21H_(2)O(UTeW_(9))and Na_(8.9)K_(2.7)H_(1.19)[K_(0.79)(UO_(2))_(2.21)(PW_(9)O_(34))_(2)]·12H_(2)O(UPW_9)using in-situ strategy and lacunary precursor strategy,***_9 shows a typical Keggin-typeopen or half-sandwich configuration.

关键词： configuration expansion sandwich