Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss

作     者：Feng-Jiao Li Da-Yong Wang Hong-Yang Wang Li Wang Feng-Bo Yang Lan Lan Jing Guan Zi-Fang Yin UII Rosenhall Lan Yu Sten Hellstrom Xi-Jun Xu Mao-Li Duan Qiu-Ju Wang Li Feng-Jiao;Wang Da-Yong;Wang Hong-Yang;Wang Li;Yang Feng-Bo;Lan Lan;Guan Jing;Yin Zi-Fang;Rosenhall Ulf;Yu Lan;Hellstrom Sten;Xue Xi-Jun;Duan Mao-Li;Wang Qiu-Ju

作者机构：Department of Otolaryngology-Head and Neck Surgery Institute of Otolaryngology Chinese PLA General Hospital Beijing 100853 China Department of Otolaryngology-Head and Neck Surgery Kunming General Hospital Kunming Medical University Kunming Yunnan 650032 China Department of Audiology and Neurotology Karolinska University Hospital 17176 Stockholm Sweden Department of Clinical Science Intervention and Technology Karolinska Institute 171 76 Stockholm Sweden 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2016年第129卷第8期

页      面：946-952页

核心收录：

学科分类：090603[农学-临床兽医学] 083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 08[工学] 09[农学] 0906[农学-兽医学] 

基　　金：This study was financially supported by grants from the National Key Basic Research Program of China，the National Natural Science Foundation of China 

主　　题：Audiological Characteristics Children Laboratory Examinations Prognostic Factors Sudden Hearing Loss 

摘      要：Background：The prevalence of sudden sensorineural hearing loss in children （CSSNHL） is consistently increasing.However,the pathology and prognosis of CSSNHL are still poorly understood.This retrospective study evaluated clinical characteristics and possible associated factors of CSSNHL.Methods：One hundred and thirty-six CSSNHL patients treated in Department of Otolaryngology-Head and Neck Surgery and Institute of Otolaryngology at Chinese PLA General Hospital between July 2008 and August 2015 were included in this study.These patients were analyzed for clinical characteristics,audiological characteristics,laboratory examinations,and prognostic factors.Results：Among the 136 patients （151 ears）,121 patients （121 ears,80.1%） were diagnosed with unilaterally CSSNHL,and 15 patients （30 ears,19.9%） with bilateral CSSNHL.The complete recovery rate of CSSNHL was 9.3%,and the overall recovery rate was 37.7%.We found that initial degree of hearing loss,onset of treatment,tinnitus,the ascending type audiogram,gender,side of hearing loss,the recorded auditory brainstem response （ABR）,and distortion product otoacoustic emissions （DPOAEs） had prognostic significance.Age,ear fullness,and vertigo had no significant correlation with recovery.Furthermore,the relevant blood tests showed 30.8% of the children had abnormal white blood cell （WBC） counts,22.1% had elevated homocysteine levels,65.8% had high alkaline phosphatase （ALP）,33.8% had high IgE antibody levels,and 86.1% had positive cytomegalovirus （CMV） IgG antibodies.Conclusions：CSSNHL commonly occurs unilaterally and results in severe hearing loss.Initial severe hearing loss and bilateral hearing loss are negative prognostic factors for hearing recovery,while positive prognostic factors include tinnitus,gender,the ascending type audiogram,early treatment,identifiable ABR waves,and DPOAEs.Age,vertigo,and ear fullness are not correlated with the recovery.Some serologic indicators,including the level of WBC,platelet,homocysteine,ALP,positive CMV IgG antibody,fibrinogen,and some immunologic indicators,are closely related to CSSNHL.